| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cholangitis | D002761 | 3 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Okayama Y and Church MK | Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. | 1992 | Int. Arch. Allergy Immunol. | pmid:1375203 |
| Smith JB et al. | Cyclic AMP does not inhibit collagen-induced platelet signal transduction. | 1992 | Biochem. J. | pmid:1375452 |
| Ikai K et al. | Induction of 72-kD heat shock protein and cytoskeleton damage by cytotoxic prostaglandin delta 12-PGJ2 in transformed human epidermal cells in culture. | 1992 | J. Invest. Dermatol. | pmid:1375619 |
| Lippton HL et al. | Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed. | 1992 | Am. J. Physiol. | pmid:1348400 |
| Crea AE et al. | Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma. | 1992 | Eur. Respir. J. | pmid:1348480 |
| Kaiser L et al. | Dirofilaria immitis: do filarial cyclooxygenase products depress endothelium-dependent relaxation in the in vitro rat aorta? | 1992 | Exp. Parasitol. | pmid:1516664 |
| Braun M and Schrör K | Prostaglandin D2 relaxes bovine coronary arteries by endothelium-dependent nitric oxide-mediated cGMP formation. | 1992 | Circ. Res. | pmid:1385004 |
| Emery BE et al. | The effect of IL-4 on human nasal mucosal responses. | 1992 | J. Allergy Clin. Immunol. | pmid:1430703 |
| Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
| Diener M et al. | Characterization of the antisecretory action of prostaglandin D2 in the rat colon. | 1992 | Acta Physiol. Scand. | pmid:1502910 |
| Hughes-Fulford M and Fukushima M | Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism. | 1993 | Life Sci Adv Exp Clin Endocrinol | pmid:11539936 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Charlesworth EN et al. | Cutaneous late-phase response in food-allergic children and adolescents with atopic dermatitis. | 1993 | Clin. Exp. Allergy | pmid:7687509 |
| al-Laith M and Pearce FL | On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells. | 1993 | Int. Arch. Allergy Immunol. | pmid:7689004 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
| Kitanaka J et al. | Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes. | 1993 | J. Neurochem. | pmid:8093482 |
| Itabashi S et al. | Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. | 1993 | Int. Arch. Allergy Immunol. | pmid:8508057 |
| Sawyer MM et al. | Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. | 1993 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:8281741 |
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| Johnston SL et al. | The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage. | 1993 | J. Allergy Clin. Immunol. | pmid:8473679 |
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| Kim IK et al. | Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells. | 1993 | FEBS Lett. | pmid:8477853 |
| Fredberg JJ et al. | Tissue resistance and the contractile state of lung parenchyma. | 1993 | J. Appl. Physiol. | pmid:8482682 |
| Baker DG et al. | Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: histamine, prostaglandin D2, prostaglandin E2 and leukotriene C4. | 1993 | Int. J. Parasitol. | pmid:8359983 |
| Morrow JD and Minton TA | Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography-mass spectrometry. | 1993 | J. Chromatogr. | pmid:8468374 |
| Faili A et al. | Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha. | 1993 | Biochem. Pharmacol. | pmid:8388209 |
| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
| Woodward DF et al. | Further studies on ocular responses to DP receptor stimulation. | 1993 | Eur. J. Pharmacol. | pmid:8440310 |
| Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
| Koizumi T et al. | Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione. | 1993 | Biochem. Pharmacol. | pmid:8328983 |
| Furukawa F et al. | Relationship between heat shock protein induction and the binding of antibodies to the extractable nuclear antigens on cultured human keratinocytes. | 1993 | J. Invest. Dermatol. | pmid:8345220 |
| Harada T et al. | Arachidonic acid metabolism by isolated and cultured middle ear epithelial cells from the chinchilla. | 1993 | Eur Arch Otorhinolaryngol | pmid:8369117 |
| Takagi T et al. | Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats. | 1993 | Calcif. Tissue Int. | pmid:8369992 |
| Püschel GP et al. | Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. | 1993 | Hepatology | pmid:8244278 |
| Neuschäfer-Rube F et al. | Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. | 1993 | Eur. J. Biochem. | pmid:8425526 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Jaffar ZH and Pearce FL | Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells. | 1993 | Agents Actions | pmid:7511869 |
| Spatz M et al. | Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505058 |
| Casolaro V et al. | Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7505332 |
| Hay DW et al. | Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea. | 1993 | Br. J. Pharmacol. | pmid:7507780 |
| Gyenes M and De Groot H | Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+. | 1993 | Am. J. Physiol. | pmid:8384798 |
| Twentyman OP et al. | The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8099592 |
| Inase N et al. | Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8217194 |
| Itoh Y et al. | [Inhibitory effects of AA-2414, a thromboxane (Tx) A2 receptor antagonist, on U-46619-, prostaglandin (PG) D2- and 9 alpha, 11 beta PGF2-induced contractions of guinea pig tracheas and isolated human bronchi]. | 1993 | Arerugi | pmid:8279967 |
| Liu P et al. | [Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8257841 |
| Rajakulasingam K et al. | Interactive effect of inhaled bradykinin with histamine and PGD2 in bronchial asthma. | 1993 | J. Appl. Physiol. | pmid:8307852 |
| Hallbrucker C et al. | Hydroperoxide metabolism in rat liver. K+ channel activation, cell volume changes and eicosanoid formation. | 1993 | Eur. J. Biochem. | pmid:8436107 |
| Aichane A et al. | Precision of conjunctival provocation tests in right and left eyes. | 1993 | J. Allergy Clin. Immunol. | pmid:8335854 |
| Barski OA and Watanabe K | Kinetic mechanism of ketoreductase activity of prostaglandin F synthase from bovine lung. | 1993 | FEBS Lett. | pmid:8458424 |
| Okuda-Ashitaka E et al. | Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla. | 1993 | Biochim. Biophys. Acta | pmid:8384001 |
| Pica F et al. | Inhibition of vesicular stomatitis virus replication by delta 12-prostaglandin J2 is regulated at two separate levels and is associated with induction of stress protein synthesis. | 1993 | Antiviral Res. | pmid:8385894 |
| Nowak D et al. | Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects. | 1993 | Eur. Respir. J. | pmid:8386107 |
| Satoh M and Yamazaki M | In vitro DNA synthesis of mouse hepatocytes stimulated by tumor necrosis factor is inhibited by glucocorticoids and prostaglandin D2 but enhanced by retinoic acid. | 1993 | J. Cell. Physiol. | pmid:8408229 |
| Bull HA et al. | Basophil mediator release in atopic dermatitis. | 1993 | J. Invest. Dermatol. | pmid:7680056 |
| Campbell AM et al. | Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. | 1993 | Allergy | pmid:7681268 |
| Maxwell DL et al. | Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. | 1993 | Eur. Respir. J. | pmid:7693506 |
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
| Sichletidis L et al. | Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. | 1993 Mar-Apr | J. Int. Med. Res. | pmid:8243793 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965770 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965771 |
| Touqui L et al. | Excretion of platelet activating factor-acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: possible role in the regulation of platelet activating factor release. | 1994 | J. Allergy Clin. Immunol. | pmid:8027488 |
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| Hoffmann R et al. | Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. | 1994 | J. Hepatol. | pmid:7814800 |
| Peden DB et al. | Hydrogen peroxide effects on rat mast cell function. | 1994 | Am. J. Physiol. | pmid:8048546 |
| Ohara H et al. | Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme. | 1994 | Biochim. Biophys. Acta | pmid:7948008 |
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| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Moussard C et al. | Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846109 |
| Woodward DF and Lawrence RA | Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells. | 1994 | Biochem. Pharmacol. | pmid:8185669 |
| Koyama Y and Hayaishi O | Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats. | 1994 | Brain Res. Bull. | pmid:8124575 |
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| Takasuka M et al. | FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships. | 1994 | J. Med. Chem. | pmid:8289201 |
| Ishimoto T et al. | Contribution of phospholipases A2 and D to arachidonic acid liberation and prostaglandin D2 formation with increase in intracellular Ca2+ concentration in rat peritoneal mast cells. | 1994 | Eur. J. Biochem. | pmid:7508386 |
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| Underwood DC et al. | Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301572 |
| el-Lati SG et al. | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | 1994 | J. Invest. Dermatol. | pmid:7513741 |
| D'Onofrio C et al. | Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction. | 1994 | Leukemia | pmid:7516027 |
| Okayama Y et al. | In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin. | 1994 | Allergy | pmid:7518654 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. | 1994 | Arch Dermatol | pmid:7979442 |
| Sakuma S et al. | Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048918 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
| Pons F et al. | Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7813544 |
| Spatz M et al. | Vasoactive peptides and prostaglandin D2 in human cerebromicrovascular endothelium. | 1994 | J. Auton. Nerv. Syst. | pmid:7836668 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Athari A et al. | Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. | 1994 | Hepatology | pmid:8020883 |
| Hirata M et al. | Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972033 |
| Lahaye DH et al. | Effect of bradykinin on loss of density-dependent growth inhibition of normal rat kidney cells. | 1994 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:7981625 |
| Tudorić N et al. | Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. | 1994 | Int. Arch. Allergy Immunol. | pmid:8111247 |
| Murakami M et al. | Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. | 1994 | J. Biol. Chem. | pmid:8071353 |
| Tran-Thi TA et al. | Effects of hypoxia on the oxygen-dependent metabolism of prostaglandins and adenosine in liver cells. | 1994 | J. Hepatol. | pmid:8071531 |
| Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
| Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |