PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Carotid Artery Thrombosis D002341 7 associated lipids
Catalepsy D002375 30 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Brain Ischemia D002545 89 associated lipids
Cholangitis D002761 3 associated lipids
Chondrosarcoma D002813 9 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Ito S et al. Problems in production of prostaglandin D2-specific antibody. 1988 Eicosanoids pmid:3273218
Seregi A et al. Functionally diverse purinergic P2Y-receptors mediate prostanoid synthesis in cultured rat astrocytes: the role of ATP-induced phosphatidyl-inositol breakdown. 1992 Eicosanoids pmid:1333251
Vigano T et al. Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. 1988 Eicosanoids pmid:3152489
Okuda-Ashitaka E et al. Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr). 1990 Eicosanoids pmid:1705811
Csanky E et al. Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. 2009 Electrophoresis pmid:19294692
Minc-Golomb D et al. Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice. 1991 EMBO J. pmid:1829676
Malki S et al. Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. 2005 EMBO J. pmid:15889150
Kim WJ et al. Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. 2007 EMBO J. pmid:18034160
Suzuki T et al. Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. 2006 Endocr. Relat. Cancer pmid:16601291
Barnea A et al. Evidence that a short-lived effect of copper leads to amplification of prostaglandin E2 stimulation of the release of gonadotropin-releasing hormone from median eminence explants. 1986 Endocrinology pmid:3525128
Schell C et al. 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. 2010 Endocrinology pmid:20133451
Winter JS et al. A stimulatory effect of interleukin-1 on adrenocortical cortisol secretion mediated by prostaglandins. 1990 Endocrinology pmid:2169407
Tomlinson JW et al. Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. 2001 Endocrinology pmid:11316764
Gadsby JE et al. Prostaglandin F2 alpha receptors on enzyme-dissociated pig luteal cells throughout the estrous cycle. 1990 Endocrinology pmid:2153525
Campbell WB and Gomez-Sanchez CE Absence of prostacyclin involvement in angiotensin-induced aldosterone secretion in rat adrenal cells. 1985 Endocrinology pmid:3924581
Poncin S et al. Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. 2008 Endocrinology pmid:17884933
Yang CY et al. Isolation and culture of two cell populations from chick calvaria by density gradient: prostaglandin synthesis by the cells in culture and coculture. 1988 Endocrinology pmid:2844516
Pirianov G et al. The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. 2009 Endocrinology pmid:18845626
Ding Q et al. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. 2009 Endocrinology pmid:19074584
Brooks DP et al. Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. 1986 Endocrinology pmid:3456303
García-Bueno B et al. Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. 2008 Endocrinology pmid:18079203
Person EC et al. Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. 2001 Endocrinology pmid:11159824
Landrier JF et al. Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. 2009 Endocrinology pmid:19833717
Yatomi A et al. Prostaglandins affect the central nervous system to produce hyperglycemia in rats. 1987 Endocrinology pmid:3474143
Kinoshita F et al. Suppressive effect of prostaglandin (PG)D2 on pulsatile luteinizing hormone release in conscious castrated rats. 1982 Endocrinology pmid:6951712
Kugathas S et al. Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX-2 Active Site, and Implications for Endocrine Disruption. 2016 Environ. Health Perspect. pmid:26359731
Akarsu ES et al. Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2. 1998 Epilepsy Res. pmid:9551845
Harada T et al. Arachidonic acid metabolism by isolated and cultured middle ear epithelial cells from the chinchilla. 1993 Eur Arch Otorhinolaryngol pmid:8369117
Wang D et al. Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. 1995 Eur Arch Otorhinolaryngol pmid:7734974
Quinteiro MS et al. The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats. 2012 Eur J Pain pmid:22354681
Tasaki M et al. Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of "chemoattractant receptor homologous molecule expressed on Th2 cells" (CRTH2). 2013 Eur J Pharm Sci pmid:23624353
Eady RP The pharmacology of nedocromil sodium. 1986 Eur J Respir Dis Suppl pmid:2429854
Schulman ES et al. Purified human basophils and mast cells: current concepts of mediator release. 1983 Eur J Respir Dis Suppl pmid:6578086
Knol EF et al. The role of basophils in allergic disease. 1996 Eur Respir J Suppl pmid:8871057
Dubourdeau M et al. Opposite roles of STAT and PPARgamma in the induction of p21WAF1 expression by IL-13 in human peripheral blood monocytes. 2008 Eur. Cytokine Netw. pmid:19103521
Tofield A Niacin and statin intolerable for some people. 2013 Eur. Heart J. pmid:24137778
Thompson NT and Scrutton MC Intracellular calcium fluxes in human platelets. 1985 Eur. J. Biochem. pmid:3918866
Iwai M et al. Potential role for prostaglandin F2 alpha, D2, E2 and thromboxane A2 in mediating the metabolic and hemodynamic actions of sympathetic nerves in perfused rat liver. 1988 Eur. J. Biochem. pmid:3165341
Murakami M et al. Release of 14-kDa group-II phospholipase A2 from activated mast cells and its possible involvement in the regulation of the degranulation process. 1992 Eur. J. Biochem. pmid:1382985
Ishimoto T et al. Contribution of phospholipases A2 and D to arachidonic acid liberation and prostaglandin D2 formation with increase in intracellular Ca2+ concentration in rat peritoneal mast cells. 1994 Eur. J. Biochem. pmid:7508386
Neuschäfer-Rube F et al. Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. 1993 Eur. J. Biochem. pmid:8425526
Sawada H et al. Regulation of type V phospholipase A2 expression and function by proinflammatory stimuli. 1999 Eur. J. Biochem. pmid:10469147
Dieter P et al. Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. 1987 Eur. J. Biochem. pmid:2826152
Hallbrucker C et al. Hydroperoxide metabolism in rat liver. K+ channel activation, cell volume changes and eicosanoid formation. 1993 Eur. J. Biochem. pmid:8436107
Dieter P et al. Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. 1988 Eur. J. Biochem. pmid:2846298
Liu X et al. 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. 2012 Eur. J. Cell Biol. pmid:22560326
Zijlstra FJ et al. Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187. 1987 Eur. J. Clin. Invest. pmid:2822430
Royer JF et al. A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils. 2008 Eur. J. Clin. Invest. pmid:18837743
Pustovrh MC et al. MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. 2009 Eur. J. Clin. Invest. pmid:19811527
Sinzinger H et al. Isradipine improves platelet function in hypertensives. 1992 Eur. J. Clin. Pharmacol. pmid:1531796
Saarinen JV et al. Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2. 2001 Eur. J. Clin. Pharmacol. pmid:11372583
Van Hecken A et al. The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. 2007 Eur. J. Clin. Pharmacol. pmid:17200838
Shalev A and Meier CA Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis. 1996 Eur. J. Endocrinol. pmid:8664970
Graf BA et al. Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. 1999 Eur. J. Immunol. pmid:10556836
Niyonsaba F et al. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. 2001 Eur. J. Immunol. pmid:11298331
Harris SG and Phipps RP The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. 2001 Eur. J. Immunol. pmid:11298334
Shin J et al. Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1. 2013 Eur. J. Immunol. pmid:23065777
Sugiyama H et al. Peroxisome proliferator-activated receptors are expressed in human cultured mast cells: a possible role of these receptors in negative regulation of mast cell activation. 2000 Eur. J. Immunol. pmid:11093153
Gebhardt T et al. Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. 2002 Eur. J. Immunol. pmid:12209644
Berry A et al. IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. 2007 Eur. J. Immunol. pmid:17458857
Chacón P et al. Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. 2005 Eur. J. Immunol. pmid:15997464
Faveeuw C et al. Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. 2003 Eur. J. Immunol. pmid:12672054
Schratl P et al. Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase. 2006 Eur. J. Immunol. pmid:16906532
Comabella M et al. Plasma levels of 15d-PGJ are not altered in multiple sclerosis. 2009 Eur. J. Neurol. pmid:19538219
Bernardo A et al. Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions. 2000 Eur. J. Neurosci. pmid:10947800
Saleem S et al. PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. 2007 Eur. J. Neurosci. pmid:17573924
Satoh T et al. Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. 2003 Eur. J. Neurosci. pmid:12814358
Arai I et al. Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. 2007 Eur. J. Pharmacol. pmid:17141215
Moreira V et al. A catalytically-inactive snake venom Lys49 phospholipase Aâ‚‚ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. 2013 Eur. J. Pharmacol. pmid:23416211
Takayanagi I et al. Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations. 1991 Eur. J. Pharmacol. pmid:1674919
Aoun P et al. Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells. 2003 Eur. J. Pharmacol. pmid:12860474
Rahman A et al. Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. 2007 Eur. J. Pharmacol. pmid:17112500
Roy SJ et al. Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. 2010 Eur. J. Pharmacol. pmid:20035740
Arai I et al. Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. 2004 Eur. J. Pharmacol. pmid:15556157
Siegl PK and Wenger HC Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog. 1985 Eur. J. Pharmacol. pmid:3899681
Chiang PC et al. Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. 2006 Eur. J. Pharmacol. pmid:16806159
Shikada K et al. NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea. 1991 Eur. J. Pharmacol. pmid:1814761
Eto K et al. Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle. 2001 Eur. J. Pharmacol. pmid:11438300
Sugimoto H et al. CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. 2005 Eur. J. Pharmacol. pmid:16256979
Gallant MA et al. Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. 2007 Eur. J. Pharmacol. pmid:17207480
Yasui K et al. Contribution of prostaglandin D2 via prostanoid DP receptor to nasal hyperresponsiveness in guinea pigs repeatedly exposed to antigen. 2008 Eur. J. Pharmacol. pmid:17927976
Cao J et al. In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium. 2002 Eur. J. Pharmacol. pmid:12020689
Gao W et al. Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2). 2009 Eur. J. Pharmacol. pmid:19249295
Moore PK et al. Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro. 1988 Eur. J. Pharmacol. pmid:3053211
Hirano Y et al. Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. 2007 Eur. J. Pharmacol. pmid:17307163
Maruyama T et al. Prostaglandin D(2) induces contraction via thromboxane A(2) receptor in rat liver myofibroblasts. 2008 Eur. J. Pharmacol. pmid:18586024
Dembinska-Kieć A et al. Formation of leukotriene C4-like material by rat brain tissue. 1984 Eur. J. Pharmacol. pmid:6426980
Mezei Z et al. Platelet eicosanoids and the effect of captopril in blood pressure regulation. 1997 Eur. J. Pharmacol. pmid:9527508
Horiguchi S et al. Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. 1986 Eur. J. Pharmacol. pmid:3458588
Tanaka T et al. Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. 2005 Eur. J. Pharmacol. pmid:15680279
Fernandes B and Crankshaw D Functional characterization of the prostanoid DP receptor in human myometrium. 1995 Eur. J. Pharmacol. pmid:7498323
Inoue K et al. Effect of 15-deoxy-delta 12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice. 2003 Eur. J. Pharmacol. pmid:14642794
Collin M and Thiemermann C The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. 2003 Eur. J. Pharmacol. pmid:12969773
Ferreira-Silva V et al. Effects of 15-deoxy-Delta12, 14 prostaglandin J2 and ciglitazone on human cancer cell cycle progression and death: the role of PPARgamma. 2008 Eur. J. Pharmacol. pmid:18054911
Pons F et al. Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182. 1994 Eur. J. Pharmacol. pmid:7813544
Wright DH et al. A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. 1999 Eur. J. Pharmacol. pmid:10448933
Jongejan R et al. Effect of epithelial denudation, inflammatory mediators and mast cell activation on the sensitivity of isolated human airways to methacholine. 1991 Eur. J. Pharmacol. pmid:1800116
Deckers IA et al. Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. 1989 Eur. J. Pharmacol. pmid:2806380
Karimi K et al. Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. 2004 Eur. J. Pharmacol. pmid:15063154
Khan AH et al. Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility. 2008 Eur. J. Pharmacol. pmid:18177857