| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cholangitis | D002761 | 3 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Storer PD et al. | Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. | 2005 | J. Neuroimmunol. | pmid:15748950 |
| Spik I et al. | Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. | 2005 | J. Immunol. | pmid:15749909 |
| Nakajima N et al. | [Alternation of ion transport of airway epithelium by eicosanoids]. | 2005 | Arerugi | pmid:16407682 |
| Chen WC et al. | Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. | 2005 | Chin. Med. J. | pmid:16157051 |
| Uehara Y | [Prostaglandin D2]. | 2005 | Nippon Rinsho | pmid:16149440 |
| Zamuner SR et al. | Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. | 2005 | Am. J. Pathol. | pmid:16251413 |
| Negoro H et al. | Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. | 2005 | Life Sci. | pmid:16154157 |
| O'Flaherty JT et al. | 5-Oxo-ETE analogs and the proliferation of cancer cells. | 2005 | Biochim. Biophys. Acta | pmid:16154383 |
| Schmidt R et al. | LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16172029 |
| Shiraki T et al. | Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. | 2005 | J. Biol. Chem. | pmid:15695504 |
| Bulló M et al. | Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15713689 |
| GarcÃa-Bueno B et al. | The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. | 2005 | Psychopharmacology (Berl.) | pmid:15719215 |
| Hashimoto Y et al. | Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. | 2005 | J. Pharmacol. Sci. | pmid:15879676 |
| MartÃn AR et al. | The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. | 2005 | Inflamm. Res. | pmid:15883736 |
| Chen YC et al. | Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. | 2005 | Biochim. Biophys. Acta | pmid:15843042 |
| Lappas M et al. | Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes. | 2004 Sep-Oct | Placenta | pmid:15450387 |
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| Józkowicz A et al. | Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14715242 |
| Neuhofer W et al. | Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. | 2004 | Kidney Int. | pmid:14717913 |
| Ward JE et al. | PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. | 2004 | Br. J. Pharmacol. | pmid:14718259 |
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| Waits PS et al. | Nociceptin/orphanin FQ modulates human T cell function in vitro. | 2004 | J. Neuroimmunol. | pmid:15020071 |
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| Diab A et al. | Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. | 2004 | J. Neuroimmunol. | pmid:14975592 |
| Paumi CM et al. | Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). | 2004 | Biochemistry | pmid:14979731 |
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| Cheng S et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. | 2004 | J. Biol. Chem. | pmid:15023995 |
| Alvarez-Maqueda M et al. | 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. | 2004 | J. Biol. Chem. | pmid:15024026 |
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| Qin C et al. | A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. | 2004 | Mol. Cancer Ther. | pmid:15026545 |
| Hashimoto K et al. | Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. | 2004 | Pancreas | pmid:15028947 |
| Toyomoto M et al. | Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. | 2004 | FEBS Lett. | pmid:15044028 |
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| Tsuji T et al. | Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. | 2004 | Biol. Pharm. Bull. | pmid:15467193 |
| Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
| Huang H et al. | Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. | 2004 | Mol. Cancer Res. | pmid:15498928 |
| Asami-Miyagishi R et al. | Expression and function of PPARgamma in rat placental development. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14766236 |
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| Bochenek G et al. | Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. | 2004 | Thorax | pmid:15170023 |
| Cheron A et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. | 2004 | J. Immunol. | pmid:15187150 |
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| Weber SM et al. | PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:14600076 |
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| Shahab R et al. | Prostaglandins, leukotrienes and perennial rhinitis. | 2004 | J Laryngol Otol | pmid:15318955 |
| Lim SY et al. | 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. | 2004 | J. Biol. Chem. | pmid:15319433 |
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| Ichiki T et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369766 |
| Schlezinger JJ et al. | Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. | 2004 | J. Immunol. | pmid:15322177 |
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| Morosetti R et al. | The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. | 2004 | Int. J. Oncol. | pmid:15254749 |
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| Chana RS et al. | Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. | 2004 | Kidney Int. | pmid:15149321 |
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| Akbiyik F et al. | Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. | 2004 | Blood | pmid:15130939 |
| Han S et al. | Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. | 2004 | Chest | pmid:15136464 |
| Collin M et al. | Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. | 2004 | Crit. Care Med. | pmid:15090969 |
| Baolin L et al. | Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. | 2004 | Planta Med. | pmid:15095144 |
| Zang C et al. | Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. | 2004 | Leuk. Res. | pmid:15109539 |
| Jakob M et al. | Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. | 2004 | Rheumatology (Oxford) | pmid:15113997 |
| Verrier E et al. | PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. | 2004 | Circ. Res. | pmid:15117825 |
| Leung WK et al. | Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. | 2004 | Gut | pmid:14960510 |
| Mouihate A et al. | A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. | 2004 | J. Neurosci. | pmid:14960602 |
| Chatterjee PK et al. | The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. | 2004 | Cardiovasc. Res. | pmid:14962493 |
| Brummond KM et al. | The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry. | 2004 | Org. Lett. | pmid:14723515 |