PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishii T et al. | Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. | 2009 | Blood | pmid:19196660 |
| Passeron T et al. | Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. | 2009 | J. Clin. Invest. | pmid:19273910 |
| Xue L et al. | Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells. | 2009 | Clin. Exp. Immunol. | pmid:19220324 |
| Ono E et al. | Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis. | 2009 | Clin. Exp. Allergy | pmid:19128354 |
| Leduc M et al. | Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19584306 |
| Bai G et al. | Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. | 2009 | Peptides | pmid:19539681 |
| Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
| Kalogeromitros D et al. | A quercetin containing supplement reduces niacin-induced flush in humans. | 2008 Jul-Sep | Int J Immunopathol Pharmacol | pmid:18831918 |
| Papageorgiou E et al. | Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. | 2008 Jul-Aug | Mol. Med. | pmid:18475308 |
| Pettipher R and Hansel TT | Antagonists of the prostaglandin D2 receptor CRTH2. | 2008 Jul-Aug | Drug News Perspect. | pmid:18836589 |
| Takahashi N et al. | Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. | 2008 Jul-Aug | Channels (Austin) | pmid:18769139 |
| Tokuda H et al. | Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771907 |
| Wang S et al. | AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. | 2008 | Mol. Cell. Endocrinol. | pmid:18508192 |
| Curfs DM et al. | Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. | 2008 | J. Biol. Chem. | pmid:18511424 |
| Qiao L et al. | Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. | 2008 | Cancer Lett. | pmid:18477501 |
| Davidson J et al. | 7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells. | 2008 | J. Steroid Biochem. Mol. Biol. | pmid:18996481 |
| Reddy RC et al. | Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. | 2008 | Blood | pmid:18535203 |
| Chana RS et al. | Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. | 2008 | Am. J. Nephrol. | pmid:18535368 |
| Andersen HB et al. | Comparison of short term in vitro cultured human mast cells from different progenitors - Peripheral blood-derived progenitors generate highly mature and functional mast cells. | 2008 | J. Immunol. Methods | pmid:18538784 |
| Reyes-Martin P et al. | 15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. | 2008 | Pharmacol. Res. | pmid:18456507 |
| Yoon HJ et al. | Regulation of TLR2 expression by prostaglandins in brain glia. | 2008 | J. Immunol. | pmid:18523308 |
| Bissonnette SL et al. | An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. | 2008 | J. Immunol. | pmid:18641309 |
| Qiao L et al. | Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. | 2008 | Mol. Cancer Ther. | pmid:18645029 |
| Ragolia L et al. | Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18619553 |
| Moreira V et al. | Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases. | 2008 | Toxicon | pmid:18619987 |
| Capobianco E et al. | Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. | 2008 | Mol. Hum. Reprod. | pmid:18621767 |
| Butterfield JH and Weiler CR | Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production. | 2008 | Int. Arch. Allergy Immunol. | pmid:18622141 |
| Corren J et al. | Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. | 2008 | Nutr J | pmid:18625073 |
| Tonge D et al. | Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins. | 2008 | J. Cell. Sci. | pmid:18650498 |
| Fujimori K et al. | Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. | 2008 | Gene | pmid:18817855 |
| GarcÃa-Bueno B et al. | Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. | 2008 | Endocrinology | pmid:18079203 |
| Muñoz U et al. | On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. | 2008 | Cell. Mol. Life Sci. | pmid:18818877 |
| Grill M et al. | Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. | 2008 | J. Neurochem. | pmid:18028337 |
| Song WL et al. | Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. | 2008 | J. Biol. Chem. | pmid:17993463 |
| Ferreira-Silva V et al. | Effects of 15-deoxy-Delta12, 14 prostaglandin J2 and ciglitazone on human cancer cell cycle progression and death: the role of PPARgamma. | 2008 | Eur. J. Pharmacol. | pmid:18054911 |
| Perbandt M et al. | Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus. | 2008 | J. Mol. Biol. | pmid:18258257 |
| Kim EH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. | 2008 | Carcinogenesis | pmid:18192694 |
| Prenn C et al. | CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine. | 2008 | Pharmacology | pmid:18212515 |
| Rajakariar R et al. | Novel biphasic role for lymphocytes revealed during resolving inflammation. | 2008 | Blood | pmid:18218853 |
| Kuesap J et al. | Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18174022 |
| Oh JY et al. | Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. | 2008 | Biochem. J. | pmid:18237271 |
| Ono E et al. | Salicylamide-induced anaphylaxis: increased urinary leukotriene E4 and prostaglandin D2 metabolite. | 2008 | Allergy | pmid:18315738 |
| Hao GH et al. | Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts. | 2008 | Br. J. Pharmacol. | pmid:18278065 |
| Khan AH et al. | Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility. | 2008 | Eur. J. Pharmacol. | pmid:18177857 |
| Inoue T et al. | Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. | 2008 | Atherosclerosis | pmid:18436228 |
| Nomiya R et al. | CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. | 2008 | J. Immunol. | pmid:18390753 |
| Liu Y et al. | Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. | 2008 | Vet. Immunol. Immunopathol. | pmid:18394717 |
| Cao J et al. | Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18403225 |
| Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
| Churi SB et al. | Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. | 2008 | J Pain | pmid:18387855 |