PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Sneezing D012912 6 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Tauopathies D024801 6 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Thrombophilia D019851 6 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Leukemia, Megakaryoblastic, Acute D007947 7 associated lipids
Folliculitis D005499 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Thyroid Diseases D013959 8 associated lipids
Leiomyoma D007889 8 associated lipids
Retinopathy of Prematurity D012178 9 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Westcott JY and Murphy RC The interaction of ethanol and exogenous arachidonic acid in the formation of leukotrienes and prostaglandin D2 in mastocytoma cells. 1983 Prostaglandins pmid:6316419
Meuten DJ et al. Hypercalcemia in dogs with adenocarcinoma derived from apocrine glands of the anal sac. Biochemical and histomorphometric investigations. 1983 Lab. Invest. pmid:6300551
Town MH et al. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. 1983 Prostaglandins pmid:6302737
Bedwani JR et al. Effects of prostaglandins E2, I2 and D2 on pig nasal vasculature. 1983 Clin Otolaryngol Allied Sci pmid:6357570
Osama H et al. Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. 1983 Biochim. Biophys. Acta pmid:6407532
Schulman ES et al. Heterogeneity of human mast cells. 1983 J. Immunol. pmid:6194221
Philips JB and Lyrene RK Persistent pulmonary hypertension and prostaglandin D2. 1983 Prog. Clin. Biol. Res. pmid:6577475
Fukushima M [Development of antineoplastic prostaglandins]. 1983 Gan To Kagaku Ryoho pmid:6577812
Schulman ES et al. Purified human basophils and mast cells: current concepts of mediator release. 1983 Eur J Respir Dis Suppl pmid:6578086
Fitzpatrick FA and Wynalda MA Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. 1983 J. Biol. Chem. pmid:6578214