| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thrombosis | D013927 | 49 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Uremia | D014511 | 33 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gualde N et al. | Stimulation of prostaglandin synthesis by the serum factor (FTS). | 1982 | Cell. Immunol. | pmid:6957270 |
| Tokumoto H et al. | An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. | 1982 | J. Biol. Chem. | pmid:6958674 |
| Narumiya S et al. | Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. | 1982 | Life Sci. | pmid:6960222 |
| Ueno R et al. | Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6960896 |
| Fukushima M et al. | 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6961920 |
| Ishizawa M and Minowa T | Effects of PGD2 and PGF2 alpha on longitudinal and circular muscles of guinea-pig isolated proximal colon. | 1982 | Prostaglandins | pmid:6962973 |
| Peters SP et al. | The role of prostaglandin D2 in IgE-mediated reactions in man. | 1982 | Trans. Assoc. Am. Physicians | pmid:6963831 |
| Fukushima M et al. | [Antineoplastic action of prostaglandin D2--effect of PGD2 on proliferation of L1210 leukemic cells in culture]. | 1982 | Gan To Kagaku Ryoho | pmid:6964030 |
| Ueno R et al. | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6964402 |
| Toda N | Different responsiveness of a variety of isolated dog arteries to prostaglandin D2. | 1982 | Prostaglandins | pmid:6950464 |
| Watanabe T et al. | Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. | 1982 | J. Biol. Chem. | pmid:6816798 |
| Karniguian A et al. | Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cAMP level. | 1982 | Prostaglandins | pmid:6287536 |
| Shimizu T et al. | Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution. | 1982 | J. Biol. Chem. | pmid:6292197 |
| Westcott JY and Murphy RC | The interaction of ethanol and exogenous arachidonic acid in the formation of leukotrienes and prostaglandin D2 in mastocytoma cells. | 1983 | Prostaglandins | pmid:6316419 |
| Homma T and Malik KU | Effect of secretin and caerulein in canine pancreas: relation to prostaglandins. | 1983 | Am. J. Physiol. | pmid:6344655 |
| Yamashita A et al. | Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6310617 |
| Hall TJ and Brostoff J | Inhibition of human natural killer cell activity by prostaglandin D2. | 1983 | Immunol. Lett. | pmid:6321333 |
| Osama H et al. | Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. | 1983 | Biochim. Biophys. Acta | pmid:6407532 |
| Schulman ES et al. | Heterogeneity of human mast cells. | 1983 | J. Immunol. | pmid:6194221 |
| Hayaishi O | [The brain and prostaglandins]. | 1983 | Rinsho Shinkeigaku | pmid:6587956 |