| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Dirofilariasis | D004184 | 3 associated lipids |
| Down Syndrome | D004314 | 18 associated lipids |
| Dyskinesia, Drug-Induced | D004409 | 15 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Epilepsy, Tonic-Clonic | D004830 | 2 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Folliculitis | D005499 | 7 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Goiter | D006042 | 4 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Headache | D006261 | 4 associated lipids |
| Hematoma | D006406 | 5 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang JJ and Mak OT | Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21396480 |
| Nabe T et al. | Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21601002 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Ragolia L et al. | Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18619553 |
| O'Sullivan S et al. | Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410385 |
| Mazid MA et al. | Development of enzyme-linked immunosorbent assay for prostaglandin D2 using the stable isosteric analogue as a hapten mimic and its application. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17481559 |
| Willermain F et al. | 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939878 |
| Lim HJ et al. | PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939881 |
| Marcone S and Fitzgerald DJ | Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. | 2013 | Proteomics | pmid:23606334 |
| Nishino S et al. | Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture. | 1998 | Psychiatry Res | pmid:9657418 |
| Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
| GarcÃa-Bueno B et al. | The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. | 2005 | Psychopharmacology (Berl.) | pmid:15719215 |
| Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
| Wang X et al. | Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. | 2009 | Pulm Pharmacol Ther | pmid:19489131 |
| Rubin DB et al. | The influence of exogenous eicosanoids on the radiation response of cultured bovine aortic endothelial cells. | 1991 | Radiat. Res. | pmid:1898781 |
| Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
| Wall SB et al. | Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. | 2015 | Redox Biol | pmid:25677088 |
| Elremaly W et al. | Ascorbylperoxide from parenteral nutrition induces an increase of redox potential of glutathione and loss of alveoli in newborn guinea pig lungs. | 2014 | Redox Biol | pmid:25009773 |
| Higashihara H et al. | Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. | 2004 | Redox Rep. | pmid:15720834 |
| Takagi T et al. | A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. | 2004 | Redox Rep. | pmid:15720836 |