Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Maurin AC et al. | Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. | 2005 | Calcif. Tissue Int. | pmid:15868283 |
Yoshida M et al. | Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts. | 2005 | J. Rheumatol. | pmid:15868610 |
Li X et al. | Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. | 2005 | J. Rheumatol. | pmid:15868626 |
De Oliveira C et al. | Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. | 2005 | J. Lab. Clin. Med. | pmid:15871306 |
Planagumà A et al. | The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. | 2005 | FASEB J. | pmid:15876570 |
Kim HY et al. | Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. | 2005 | Immunol. Cell Biol. | pmid:15877607 |
Blanco M et al. | Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. | 2005 | Stroke | pmid:15879329 |
Hashimoto Y et al. | Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. | 2005 | J. Pharmacol. Sci. | pmid:15879676 |
Raible DG et al. | Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. | 1992 | J. Immunol. | pmid:1588043 |
Marchini C et al. | Aspirin modulates LPS-induced nitric oxide release in rat glial cells. | 2005 Jun 10-17 | Neurosci. Lett. | pmid:15882795 |
MartÃn AR et al. | The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. | 2005 | Inflamm. Res. | pmid:15883736 |
Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
Malki S et al. | Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. | 2005 | EMBO J. | pmid:15889150 |
Capobianco E et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. | 2005 | Reprod. Fertil. Dev. | pmid:15899154 |
Avis I et al. | Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. | 2005 | Cancer Res. | pmid:15899809 |
Wang Z and Figueiredo-Pereira ME | Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity. | 2005 | Mol. Cell. Neurosci. | pmid:15911346 |
Ishida A et al. | Characterization of cAMP-dependent proteolysis of GATA-6. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15913546 |
Hennersdorf F et al. | Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. | 2005 | Cell Res. | pmid:15916720 |
Hosoya T et al. | Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. | 2005 | J. Biol. Chem. | pmid:15917255 |
D'Onofrio C et al. | Comparative anti-viral and anti-proliferative activity of PGA1 and PGJ2 against HTLV-I-infected MT-2 cells. | 1992 | Int. J. Cancer | pmid:1592539 |
Kunkel SL et al. | Suppression of immune complex vasculitis in rats by prostaglandin. | 1979 | J. Clin. Invest. | pmid:159314 |
Tomita H et al. | Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. | 2005 | Cardiovasc. Res. | pmid:15949477 |
Wang D et al. | Terbutaline acts at multiple sites to inhibit bronchoconstriction induced by dry air in canine peripheral airways. | 1992 | Am. Rev. Respir. Dis. | pmid:1595994 |
Ibabe A et al. | Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. | 2005 | Toxicol In Vitro | pmid:15964169 |
Hogaboam CM et al. | Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds. | 1992 | Br. J. Pharmacol. | pmid:1596692 |
Núñez NP et al. | PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. | 2006 | Cancer Lett. | pmid:15979236 |
Kaplan JM et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. | 2005 | Shock | pmid:15988322 |
Costello DA et al. | Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. | 2005 | Neuropharmacology | pmid:15993441 |
Patel KM et al. | Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). | 2005 | Cell. Signal. | pmid:15993751 |
Zurich MG et al. | Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. | 2005 | Neuroscience | pmid:15994020 |
Chacón P et al. | Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. | 2005 | Eur. J. Immunol. | pmid:15997464 |
Honma Y et al. | Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. | 2005 | Eur. J. Pharmacol. | pmid:16000196 |
Kim HJ et al. | 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. | 2005 | Exp. Mol. Med. | pmid:16000871 |
Pande V and Ramos MJ | Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16006125 |
Eggler AL et al. | Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16006525 |
Matsuzaki Y et al. | 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. | 2005 | Int. J. Oncol. | pmid:16010433 |
Polikandriotis JA et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16020752 |
Kim J et al. | Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. | 2005 | Cancer Res. | pmid:16024620 |
Hata AN et al. | Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. | 2005 | J. Biol. Chem. | pmid:16030019 |
Pereira MP et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16034372 |
Mouihate A et al. | Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16037126 |
Nakae K et al. | Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. | 2005 | Neurosci. Lett. | pmid:16039053 |
Gelir E et al. | Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16039105 |
Masini E et al. | Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. | 2005 | Free Radic. Biol. Med. | pmid:16043023 |
Muñoz U et al. | The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. | 2005 | Exp. Neurol. | pmid:16061222 |
Chen ZY and Tseng CC | 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. | 2005 | Mol. Pharmacol. | pmid:16077033 |
Chevalier E et al. | Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. | 2005 | J. Immunol. | pmid:16081770 |
Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
Stahlschmidt J et al. | Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. | 2005 | Kidney Int. | pmid:16105033 |
Appel S et al. | PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. | 2005 | Blood | pmid:16105976 |
Boyce JA | Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications. | 2005 | Chem Immunol Allergy | pmid:16107763 |
Millán O et al. | Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. | 2006 | Carcinogenesis | pmid:16113051 |
Choi YH et al. | New anti-inflammatory formulation containing Synurus deltoides extract. | 2005 | Arch. Pharm. Res. | pmid:16114500 |
Conti P et al. | Role of lipoxins A4 and B4 in the generation of arachidonic acid metabolites by rat mast cells and their effect on [3H]serotonin release. | 1992 | Immunol. Lett. | pmid:1612634 |
Noguchi J et al. | Strain difference of murine bone marrow-derived mast cell functions. | 2005 | J. Leukoc. Biol. | pmid:16126842 |
Jin YR et al. | An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. | 2005 | Basic Clin. Pharmacol. Toxicol. | pmid:16128910 |
Yuhas Y et al. | Involvement of prostaglandins in an animal model of Shigella-related seizures. | 2005 | J. Neuroimmunol. | pmid:16139898 |
Hatoum OA et al. | Novel mechanism of vasodilation in inflammatory bowel disease. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141408 |
Uehara Y | [Prostaglandin D2]. | 2005 | Nippon Rinsho | pmid:16149440 |
Negoro H et al. | Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. | 2005 | Life Sci. | pmid:16154157 |
O'Flaherty JT et al. | 5-Oxo-ETE analogs and the proliferation of cancer cells. | 2005 | Biochim. Biophys. Acta | pmid:16154383 |
Benkirane K et al. | PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16155101 |
Calabrò P et al. | Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. | 2005 Nov-Dec | J. Vasc. Res. | pmid:16155367 |
Coyle AT et al. | 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. | 2005 | FEBS J. | pmid:16156795 |
Chen WC et al. | Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. | 2005 | Chin. Med. J. | pmid:16157051 |
Schmidt R et al. | LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16172029 |
Grill M et al. | Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. | 2006 | Neuropharmacology | pmid:16182321 |
Wilhelm D et al. | Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. | 2005 | Dev. Biol. | pmid:16185683 |
Armer RE et al. | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. | 2005 | J. Med. Chem. | pmid:16190744 |
Koh SH et al. | 15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant? | 2005 | Toxicology | pmid:16191461 |
Soares AF et al. | Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16198309 |
Zhao X et al. | 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16208315 |
Gayarre J et al. | Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione. | 2005 | FEBS Lett. | pmid:16223487 |
Garg TK and Chang JY | Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16225932 |
Marone G et al. | Role of human mast cells and basophils in bronchial asthma. | 2005 | Adv. Immunol. | pmid:16227089 |
Fujishima H et al. | Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis. | 2005 | Cornea | pmid:16227827 |
Shiraki T et al. | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. | 2006 | Biochem. J. | pmid:16236024 |
Kobayashi Y et al. | Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. | 2005 | J. Immunol. | pmid:16237065 |
Shibata T and Uchida K | [Current opinions on prostaglandin J2]. | 2005 | Seikagaku | pmid:16241007 |
Zamuner SR et al. | Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. | 2005 | Am. J. Pathol. | pmid:16251413 |
Na HK et al. | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. | 2005 | FEBS Lett. | pmid:16253239 |
Sugimoto H et al. | CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. | 2005 | Eur. J. Pharmacol. | pmid:16256979 |
Jawerbaum A et al. | Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. | 2005 | Reproduction | pmid:16264098 |
Landar A et al. | Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. | 2006 | Biochem. J. | pmid:16268779 |
Cesario RM et al. | Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. | 2006 | Cancer Lett. | pmid:16271436 |
Mandal AK et al. | Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation. | 2005 | J. Immunol. | pmid:16272277 |
Xue L et al. | Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. | 2005 | J. Immunol. | pmid:16272307 |
Sugimoto M et al. | Increased scratching counts depend on a decrease in ability of cutaneous prostaglandin D2 biosynthesis in NC/Nga mice with atopic dermatitis. | 2005 | Exp. Dermatol. | pmid:16274457 |
Shiraki T et al. | [Activation mechanism of PPARgamma by its endogenous ligands]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16277244 |
Bianchi A et al. | Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. | 2005 | Arthritis Res. Ther. | pmid:16277686 |
Bate C et al. | Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. | 2006 | Neuropharmacology | pmid:16289250 |
Bellows CF et al. | Modulation of macrophage nitric oxide production by prostaglandin D2. | 2006 | J. Surg. Res. | pmid:16289592 |
Helliwell RJ et al. | Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. | 2006 | J. Clin. Endocrinol. Metab. | pmid:16291703 |
Stamatakis K et al. | Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. | 2006 | J. Am. Soc. Nephrol. | pmid:16291835 |
van der Linden PW et al. | Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation. | 1992 | J. Allergy Clin. Immunol. | pmid:1629497 |
Iwata C et al. | Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. | 2005 | J. Invest. Dermatol. | pmid:16297182 |
Thomas RK et al. | Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. | 2005 | Clin. Cancer Res. | pmid:16299251 |
Herlong JL and Scott TR | Positioning prostanoids of the D and J series in the immunopathogenic scheme. | 2006 | Immunol. Lett. | pmid:16310861 |
Wu CC et al. | 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. | 2005 | Eur. J. Pharmacol. | pmid:16313903 |