Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
Balzar S et al. | Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20813890 |
Kumar VB et al. | Angiogenic effect of laminin involves modulation of cyclooxygenase-2 and prostaglandin levels. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21148739 |
Higuchi S et al. | IL-4 mediates dicloxacillin-induced liver injury in mice. | 2011 | Toxicol. Lett. | pmid:21094227 |
Afrin LB | Polycythemia from mast cell activation syndrome: lessons learned. | 2011 | Am. J. Med. Sci. | pmid:21642812 |
Kajiwara D et al. | Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. | 2011 | Eur. J. Pharmacol. | pmid:21645503 |
Erttmann SF et al. | PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. | 2011 | Free Radic. Biol. Med. | pmid:21651978 |
Chiba T et al. | The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. | 2011 | Ann. Allergy Asthma Immunol. | pmid:21624751 |
Liu TY et al. | [Advances in the study of histaminergic systems and sleep-wake regulation]. | 2011 | Yao Xue Xue Bao | pmid:21626776 |
Zhang Y et al. | Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. | 2011 | J Mass Spectrom | pmid:21706677 |
Ugajin T et al. | FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. | 2011 | Am. J. Pathol. | pmid:21712025 |
Tobiasova Z et al. | Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. | 2011 | Circulation | pmid:21690493 |
Menon R et al. | Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. | 2011 | Obstet Gynecol | pmid:21691170 |
Chowdhury AA et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21699992 |
Yamamoto Y et al. | Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. | 2011 | Am. J. Pathol. | pmid:21703412 |
Ebersberger A et al. | Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. | 2011 | Pain | pmid:21345590 |
Ulivi V et al. | Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. | 2011 | Arthritis Res. Ther. | pmid:21682897 |
Farhat A et al. | Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | 2011 | J Ovarian Res | pmid:21352547 |
Yamamoto Y et al. | 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683069 |
Luker T et al. | Zwitterionic CRTh2 antagonists. | 2011 | J. Med. Chem. | pmid:21355602 |
Matsumoto T et al. | Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. | 2011 | Circ. J. | pmid:21325722 |
Wang P et al. | Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. | 2011 | PLoS ONE | pmid:22096605 |
Raman P et al. | 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. | 2011 | Mol. Pharmacol. | pmid:21511917 |
Lin TH et al. | 15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts. | 2011 | J. Cell. Physiol. | pmid:21344384 |
Lalier L et al. | Prostaglandins antagonistically control Bax activation during apoptosis. | 2011 | Cell Death Differ. | pmid:20966963 |
Hernandez JM and Janssen LJ | Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21768224 |
Sharma I et al. | In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells. | 2011 | Fertil. Steril. | pmid:20970133 |
Tanaka A et al. | Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21865589 |
Larsson AK et al. | Prostaglandin Dâ‚‚ induces contractions through activation of TP receptors in peripheral lung tissue from the guinea pig. | 2011 | Eur. J. Pharmacol. | pmid:21872585 |
Degousee N et al. | Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. | 2011 | J. Biol. Chem. | pmid:21849511 |
Mesquita-Santos FP et al. | Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. | 2011 | Br. J. Pharmacol. | pmid:20973774 |
Wienecke T et al. | Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin Dâ‚‚ (PGDâ‚‚). | 2011 | Cephalalgia | pmid:20974593 |
El-Shazly AE et al. | IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. | 2011 | Int. Immunopharmacol. | pmid:21835268 |
Kuehn HS et al. | Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. | 2011 | J. Biol. Chem. | pmid:20980255 |
Surh YJ et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. | 2011 | Biochem. Pharmacol. | pmid:21843512 |
Bräutigam K et al. | Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20878528 |
Alves C et al. | Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. | 2011 | Br. J. Pharmacol. | pmid:20883476 |
Lu Y et al. | Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. | 2011 | Biochem. Pharmacol. | pmid:21907188 |
Kanda N et al. | The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes. | 2011 | Immunobiology | pmid:20875690 |
Burke SJ and Collier JJ | The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells. | 2011 | Cell. Immunol. | pmid:21885043 |
Liu H et al. | Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. | 2011 | Neurobiol. Dis. | pmid:20933087 |
Crosignani S et al. | Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. | 2011 | J. Med. Chem. | pmid:21916510 |
Moniot B et al. | Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. | 2011 | Dev. Dyn. | pmid:21887724 |
Kanai Y et al. | Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue. | 2011 | J. Lipid Res. | pmid:21893678 |
Tao H and Hajri T | Very low density lipoprotein receptor promotes adipocyte differentiation and mediates the proadipogenic effect of peroxisome proliferator-activated receptor gamma agonists. | 2011 | Biochem. Pharmacol. | pmid:21924248 |
Jakob S and Lovell-Badge R | Sex determination and the control of Sox9 expression in mammals. | 2011 | FEBS J. | pmid:21281448 |
Hardy KD et al. | Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. | 2011 | J. Lipid Res. | pmid:20944061 |
Birbian N et al. | No association of PTGDR -441C/T polymorphism with asthma in a North Indian population. | 2011 | Dis. Markers | pmid:22182808 |
Yu R et al. | Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21865441 |
Koyama J et al. | Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS/MS method with positive/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells. | 2011 | Anal Bioanal Chem | pmid:21725829 |