PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
| Philips JB and Lyrene RK | Persistent pulmonary hypertension and prostaglandin D2. | 1983 | Prog. Clin. Biol. Res. | pmid:6577475 |
| Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
| Cebola I and Peinado MA | Epigenetic deregulation of the COX pathway in cancer. | 2012 | Prog. Lipid Res. | pmid:22580191 |
| Hemker DP and Aiken JW | Effects of prostaglandins on autonomic function in vivo, with special emphasis on PGD2 and PGD3. | 1981 | Prog. Lipid Res. | pmid:6952267 |
| Ishizawa M and Minowa T | Effects of PGD2 and PGF2 alpha on longitudinal and circular muscles of guinea-pig isolated proximal colon. | 1982 | Prostaglandins | pmid:6962973 |
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
| Higashiyama K et al. | Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. | 1996 | Prostaglandins | pmid:8908616 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
| Kennedy I et al. | Studies on the characterisation of prostanoid receptors: a proposed classification. | 1982 | Prostaglandins | pmid:6131499 |
| Kim HS et al. | Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. | 1996 | Prostaglandins | pmid:8873236 |
| Spannhake EW et al. | Bronchoactive metabolites of arachidonic acid and their role in airway function. | 1981 | Prostaglandins | pmid:6801729 |
| Norwitz ER et al. | Prostaglandin production by human peripheral blood monocytes changes with in vitro differentiation. | 1996 | Prostaglandins | pmid:8792444 |
| Mitsuoka S et al. | Inhibitory effect of prostaglandin delta 12-PGJ2 on cell proliferation and alpha-fetoprotein expression in HuH-7 human hepatoma cells. | 1992 | Prostaglandins | pmid:1371888 |
| Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
| Claeys M et al. | Lack of prostacyclin biosynthesis by aortic tissue of the chicken. | 1981 | Prostaglandins | pmid:6803304 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Nishizawa EE et al. | Prostaglandin d2 as a potential antithrombotic agent. | 1975 | Prostaglandins | pmid:806102 |
| Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
| Karniguian A et al. | Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cAMP level. | 1982 | Prostaglandins | pmid:6287536 |
| Town MH et al. | Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. | 1983 | Prostaglandins | pmid:6302737 |
| Whittle BJ et al. | Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. | 1983 | Prostaglandins | pmid:6344147 |
| Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
| Ramis I et al. | In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions. | 1991 | Prostaglandins | pmid:1662405 |
| Ninomiya H et al. | Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage. | 1992 | Prostaglandins | pmid:1584994 |
| Lee DY et al. | Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions. | 1992 | Prostaglandins | pmid:1542741 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. | 1989 | Prostaglandins | pmid:2475889 |
| Foreman D et al. | Effects of E2 levuglandins on the contractile activity of the rat uterus. | 1987 | Prostaglandins | pmid:3317517 |
| Shimizu Y et al. | Selective synthesis and retention of 66k protein in a human neuroblastoma cell line (NCG) treated with a cytotoxic dosage of delta 12-prostaglandin J2. | 1987 | Prostaglandins | pmid:3449899 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Black JL et al. | A comparison of the contractile activity of PGD2 and PGF2 alpha on human isolated bronchus. | 1986 | Prostaglandins | pmid:3464041 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Alvarez R et al. | Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin. | 1991 | Prostaglandins | pmid:1775633 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Bulbena O et al. | Mast cells in the rat gastric mucosa are not primarily responsible for PGD2 generation. | 1991 | Prostaglandins | pmid:1871377 |
| Hayashi H et al. | Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. | 1987 | Prostaglandins | pmid:3474704 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Gerritsen ME | PGD2 formation in the vasculature: characteristics of rat tail vein prostaglandin endoperoxide-D isomerase. | 1983 | Prostaglandins | pmid:6573722 |
| Simmet T and Jaffe BM | Inhibition of B-16 melanoma growth in vitro by prostaglandin D2. | 1983 | Prostaglandins | pmid:6573723 |
| Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
| Harris DN et al. | 9 alpha-homo-9,11-epoxy-5,13-prostadienoic acid analogues: specific stable agonist (SQ 26, 538) and antagonist (SQ 26, 536) of the human platelet thromboxane receptor. | 1981 | Prostaglandins | pmid:6270744 |