| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Korolczuk A et al. | The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. | 2014 | J. Physiol. Pharmacol. | pmid:25554991 |
| Isensee J et al. | Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. | 2014 | PLoS ONE | pmid:25551770 |
| Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation. | 2014 | Am. J. Pathol. | pmid:24650561 |
| Yen CC et al. | Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. | 2014 | Oncotarget | pmid:24566468 |
| Nieves A and Garza LA | Does prostaglandin D2 hold the cure to male pattern baldness? | 2014 | Exp. Dermatol. | pmid:24521203 |
| Jeong KT et al. | Anti-allergic effect of a Korean traditional medicine, Biyeom-Tang on mast cells and allergic rhinitis. | 2014 | BMC Complement Altern Med | pmid:24521096 |
| Jung WK et al. | The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS‑stimulated inflammation via enhancement of the platelet‑activating factor acetylhydrolase activity in human retinal pigment epithelial cells. | 2014 | Int. J. Mol. Med. | pmid:24337644 |
| Carrier EJ et al. | Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. | 2014 | Biochemistry | pmid:24684440 |
| Oyama S et al. | A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. | 2014 | Arch. Biochem. Biophys. | pmid:24239863 |
| Liu H et al. | Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus. | 2014 | Immunology | pmid:24329550 |
| Mooney JJ et al. | Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. | 2013 | J Psychiatr Res | pmid:23490066 |
| Keum JH et al. | The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells. | 2013 | Chin J Integr Med | pmid:23494327 |
| Lefils-Lacourtablaise J et al. | The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. | 2013 | PLoS ONE | pmid:23734181 |
| Zhang S et al. | Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23471341 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
| Moreira V et al. | A catalytically-inactive snake venom Lys49 phospholipase Aâ‚‚ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. | 2013 | Eur. J. Pharmacol. | pmid:23416211 |
| Heilmann S et al. | No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. | 2013 | Br. J. Dermatol. | pmid:23448296 |
| Kanda H et al. | COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. | 2013 | Glia | pmid:23505121 |
| Starkl P et al. | PLA2G3 promotes mast cell maturation and function. | 2013 | Nat. Immunol. | pmid:23685814 |
| Sánchez-Gómez FJ et al. | Modulation of GSTP1-1 oligomerization by electrophilic inflammatory mediators and reactive drugs. | 2013 | Inflamm Allergy Drug Targets | pmid:23596995 |
| Wappler EA et al. | Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. | 2013 | PLoS ONE | pmid:23658809 |
| Krohn IK et al. | Mast cell FcϵRI density and function dissociate from dependence on soluble IgE concentration at very low and very high IgE concentrations. | 2013 | J Asthma | pmid:23294195 |
| Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
| Ramer R et al. | COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. | 2013 | Mol. Cancer Ther. | pmid:23220503 |
| Haskew-Layton RE et al. | 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. | 2013 | J. Neurochem. | pmid:23199167 |
| Nakamura M et al. | Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. | 2013 | Biomed. Pharmacother. | pmid:23206752 |
| Lewis A et al. | Heterogeneity in the responses of human lung mast cells to stem cell factor. | 2013 | Clin. Exp. Allergy | pmid:23278880 |
| Philibert P et al. | Unilateral cryptorchidism in mice mutant for Ptgds. | 2013 | Hum. Mutat. | pmid:23076868 |
| Kataoka N et al. | Indomethacin inhibits eosinophil migration to prostaglandin D2 : therapeutic potential of CRTH2 desensitization for eosinophilic pustular folliculitis. | 2013 | Immunology | pmid:23582181 |
| Lu Y et al. | Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin Dâ‚‚ generation in mast cells and anaphylaxis in mice. | 2013 | Food Chem. Toxicol. | pmid:23562928 |
| Sato A et al. | Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23566516 |
| Yazid S et al. | Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. | 2013 | PLoS ONE | pmid:23527056 |
| Ayabe S et al. | Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating the DP receptor. | 2013 | J. Pharmacol. Sci. | pmid:23538675 |
| Xu X et al. | Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. | 2013 | Steroids | pmid:23707573 |
| Safaralizadeh R et al. | Influence of selenium on mast cell mediator release. | 2013 | Biol Trace Elem Res | pmid:23784732 |
| Hellmann J et al. | Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. | 2013 | J. Immunol. | pmid:23785121 |
| Moghaddami M et al. | Prostaglandin D(2) in inflammatory arthritis and its relation with synovial fluid dendritic cells. | 2013 | Mediators Inflamm. | pmid:23737645 |
| Labrecque P et al. | Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. | 2013 | PLoS ONE | pmid:23762421 |
| Lu Y et al. | Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappaB and mitogen activated protein kinase pathways in bone marrow derived-mast cells. | 2013 | Biol. Pharm. Bull. | pmid:23719635 |
| Yoo JM et al. | Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. | 2013 | Lipids | pmid:23377981 |
| Davidson J et al. | Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxyΔ(12,14) prostaglandin J2 production. | 2013 | Br. J. Pharmacol. | pmid:23586396 |
| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
| Kuriyan AE et al. | Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24135759 |
| Fajt ML et al. | Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. | 2013 | J. Allergy Clin. Immunol. | pmid:23506843 |
| Touitou V et al. | Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24106118 |
| Tofield A | Niacin and statin intolerable for some people. | 2013 | Eur. Heart J. | pmid:24137778 |
| Napimoga MH et al. | Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. | 2013 | Int. Immunopharmacol. | pmid:23597428 |
| Ramer R et al. | Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. | 2013 | J. Lipid Res. | pmid:23943857 |
| Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |
| Wu D et al. | Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. | 2013 | Mediators Inflamm. | pmid:24174713 |