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Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. |
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11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. |
2004 |
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Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). |
2004 |
Mol. Cell. Biol. |
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Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndrome. |
2004 |
J. Clin. Endocrinol. Metab. |
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[Prostaglandin D2 in allergy: PGD2 has dual receptor systems]. |
2004 |
Nippon Yakurigaku Zasshi |
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[PGD(2)/L-PGDS system in hypertension and renal injury]. |
2004 |
Nippon Yakurigaku Zasshi |
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Physiology and pharmacology of the prostaglandin J2 family. |
2004 |
Nippon Yakurigaku Zasshi |
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COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue. |
2004 |
Biochem. Pharmacol. |
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15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. |
2004 |
Biochem. Biophys. Res. Commun. |
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Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. |
2004 |
Biochem. Biophys. Res. Commun. |
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15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. |
2004 |
Prostaglandins Other Lipid Mediat. |
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Abraha D et al. |
(S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. |
2004 |
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Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells. |
2004 |
Biochem. J. |
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MITF is necessary for generation of prostaglandin D2 in mouse mast cells. |
2004 |
J. Biol. Chem. |
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Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. |
2004 |
Clin. Immunol. |
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15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. |
2004 |
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Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. |
2004 |
J. Immunol. |
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Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. |
2004 |
Am. J. Physiol. Endocrinol. Metab. |
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Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. |
2004 |
Mol. Cancer Ther. |
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Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. |
2004 |
Chem. Res. Toxicol. |
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Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? |
2004 |
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Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. |
2004 |
Life Sci. |
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Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. |
2004 |
Anticancer Drugs |
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Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15519494
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The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. |
2004 |
J. Immunol. |
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Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. |
2004 |
Arch Ital Biol |
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Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. |
2004 |
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Antitumor effects of peroxisome proliferator activate receptor gamma ligands on anaplastic thyroid carcinoma. |
2004 |
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Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. |
2004 |
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A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. |
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2004 |
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2004 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. |
2004 |
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15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. |
2004 |
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Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts. |
2004 |
J. Hepatol. |
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Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells. |
2004 |
Brain Res. |
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Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. |
2004 |
Cancer Res. |
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Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. |
2004 |
Clin. Exp. Allergy |
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S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Delta12,14- prostaglandin J2 (15d-PGJ2). |
2004 |
J. Neurochem. |
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PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. |
2004 |
Am. J. Physiol. Endocrinol. Metab. |
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Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. |
2004 |
J. Allergy Clin. Immunol. |
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Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. |
2004 |
Br. J. Cancer |
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Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes. |
2004 |
Mol. Pharmacol. |
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Prostaglandins, leukotrienes and perennial rhinitis. |
2004 |
J Laryngol Otol |
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15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. |
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Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. |
2004 |
Pharmacology |
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The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells. |
2004 |
J. Invest. Dermatol. |
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Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells. |
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Cancer Lett. |
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Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition. |
2004 |
Biochem. Biophys. Res. Commun. |
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15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. |
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Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. |
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J. Pharmacol. Exp. Ther. |
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Expression of prostaglandin D2 receptors DP1 and DP2 by human colorectal cancer cells. |
2004 |
Cancer Lett. |
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Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15172681
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CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. |
2004 |
Int. Immunol. |
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Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
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Regulation of granulocyte apoptosis by NF-kappaB. |
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Biochem. Soc. Trans. |
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Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation. |
2004 |
Biochem. Biophys. Res. Commun. |
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Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. |
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Placenta |
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Hematopoietic prostaglandin D synthase. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895599
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The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895600
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Powell WS |
A novel PGD(2) receptor expressed in eosinophils. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:12895601
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The DP receptor, allergic inflammation and asthma. |
2003 Aug-Sep |
Prostaglandins Leukot. Essent. Fatty Acids |
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Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. |
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Biochem. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. |
2003 |
Fertil. Steril. |
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Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. |
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PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes. |
2003 |
Hypertension |
pmid:12885795
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Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. |
2003 |
Gastroenterology |
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Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. |
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Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. |
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Cancer Res. |
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Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. |
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Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives. |
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Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane derivatives. |
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Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. |
2003 |
J. Pharmacol. Exp. Ther. |
pmid:12966153
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The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. |
2003 |
Eur. J. Pharmacol. |
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Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. |
2003 |
Br. J. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide. |
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Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. |
2003 |
Surgery |
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Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. |
2003 |
Arthritis Rheum. |
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Peroxisome proliferator-activated receptor-gamma activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis. |
2003 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
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Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. |
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Curr Drug Targets Inflamm Allergy |
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15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? |
2003 |
J. Clin. Invest. |
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15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. |
2003 |
World J. Gastroenterol. |
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Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. |
2003 |
FASEB J. |
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15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. |
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Lab. Invest. |
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
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Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. |
2003 |
Biochemistry |
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Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. |
2003 |
J. Immunol. |
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Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes. |
2003 |
Adv. Exp. Med. Biol. |
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15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells. |
2003 |
Int. Arch. Allergy Immunol. |
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A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2. |
2003 |
Infect. Immun. |
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Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. |
2003 |
J. Biochem. |
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Thioredoxin as a molecular target of cyclopentenone prostaglandins. |
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15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. |
2003 |
J. Pharmacol. Exp. Ther. |
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RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. |
2003 |
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Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. |
2003 |
Int. J. Cancer |
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Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. |
2003 |
Glia |
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