| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Coronavirus Infections | D018352 | 4 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Liver Failure, Acute | D017114 | 11 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, T-Cell | D016399 | 11 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Koharudin LM et al. | Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20231490 |
| Qu WM et al. | Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17093043 |
| Ueno R et al. | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6964402 |
| Satoh S et al. | Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8650205 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Cheng K et al. | Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16617107 |
| Straus DS et al. | 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781090 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Murata T et al. | Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106279 |
| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
| Kondo M et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032289 |
| Yamashita A et al. | Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6310617 |
| Eguchi N et al. | Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9892701 |
| Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
| Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
| Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
| Scammell T et al. | Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9636223 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Petrova TV et al. | Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200320 |
| Haworth O and Buckley CD | Resolving the problem of persistence in the switch from acute to chronic inflammation. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18093938 |
| Eggler AL et al. | Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16006525 |
| Kuno S et al. | Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3458226 |
| Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Hirata M et al. | Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972033 |
| Mizoguchi A et al. | Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562489 |
| Nakagawa S et al. | Evaluation of prostaglandin D2 (PGD2) as an anticoagulative agent for haemodialysis in comparison with prostaglandin E1 (PGE1). | 1981 | Proc Eur Dial Transplant Assoc | pmid:7036145 |
| Bochenek G et al. | [Prostaglandin D2: biosynthesis, biological properties and participation in bronchial asthma]. | 2001 | Pol. Arch. Med. Wewn. | pmid:11928572 |
| Gross-Sondej I et al. | [Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease]. | 2012 | Pneumonol Alergol Pol | pmid:22370980 |
| Magnussen H et al. | [Experimental effects of air pollutants on healthy probands and asthmatic patients]. | 1994 | Pneumologie | pmid:8183874 |
| Haxhiu MA et al. | [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. | 1986 Jan-Mar | Plucne Bolesti | pmid:3466189 |
| Gao D et al. | Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells. | 2015 | PLoS ONE | pmid:25874449 |
| Xu F et al. | Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. | 2013 | PLoS ONE | pmid:23372817 |
| Wang P et al. | Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. | 2011 | PLoS ONE | pmid:22096605 |
| Alba G et al. | Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. | 2012 | PLoS ONE | pmid:23115616 |
| Isensee J et al. | Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. | 2014 | PLoS ONE | pmid:25551770 |
| Paulitschke V et al. | Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. | 2012 | PLoS ONE | pmid:23049949 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Huang HL et al. | 18F-glutathione conjugate as a PET tracer for imaging tumors that overexpress L-PGDS enzyme. | 2014 | PLoS ONE | pmid:25111383 |
| Mruwat R et al. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. | 2013 | PLoS ONE | pmid:24204651 |
| Liu L et al. | Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. | 2013 | PLoS ONE | pmid:24023668 |
| Sharvit E et al. | Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. | 2013 | PLoS ONE | pmid:24098526 |
| Kim KR et al. | 15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss. | 2015 | PLoS ONE | pmid:25859665 |
| Seno T et al. | 15-Deoxy-Δ¹²,¹ⴠprostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. | 2011 | PLoS ONE | pmid:22003398 |
| de Jong E et al. | Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. | 2011 | PLoS ONE | pmid:21957481 |
| Mechiche H et al. | Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. | 2012 | PLoS ONE | pmid:22984630 |
| Khanim FL et al. | Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. | 2009 | PLoS ONE | pmid:19997560 |
| Nagata N et al. | Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. | 2017 | PLoS ONE | pmid:28394950 |
| Kida T et al. | Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. | 2016 | PLoS ONE | pmid:27992456 |