Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
Liu TY et al. | [Advances in the study of histaminergic systems and sleep-wake regulation]. | 2011 | Yao Xue Xue Bao | pmid:21626776 |
Chung HS et al. | Heat contact urticaria--a case report. | 1996 | Yonsei Med. J. | pmid:8826790 |
Greaves MW et al. | [New pharmacologic developments in physical urticaria--therapeutic consequences]. | 1987 | Z. Hautkr. | pmid:3472418 |
Lou HQ et al. | [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175238 |
Chi Y et al. | [Effect of 15-deoxy-Δ(12), 14-prostaglandin J2 on the cytokines in the culture supernatant of bone marrow mesenchymal stem cells]. | 2013 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24370048 |
Yue TL and Mai K | [Effects of protein malnutrition on the metabolism of arachidonic acid in the rat stomach and spleen]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3142210 |
Li WY et al. | Effect of 15-Deoxy-â–³(12,14)-prostaglandin J2 on Expression of Macrophage Migration Inhibitory Factor in Mouse Monocyte/macrophage Cell Line J774A.1. | 2016 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:27544994 |
Ye P et al. | [The role of peroxisome proliferator-activated receptor gamma in proliferation of cardiac non myocytes]. | 2006 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162229 |
Liu P et al. | [Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8257841 |