PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang P et al. | The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. | 2012 | J. Biol. Chem. | pmid:22829602 |
| Nicholson JD et al. | PGJ(2) provides prolonged CNS stroke protection by reducing white matter edema. | 2012 | PLoS ONE | pmid:23284631 |
| Xiao L et al. | Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages. | 2012 | PLoS ONE | pmid:23226252 |
| Sykes L et al. | Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. | 2012 | PLoS ONE | pmid:23226366 |
| Yamaura K et al. | Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis. | 2012 | J Toxicol Sci | pmid:23208428 |
| Bardelli C et al. | Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. | 2012 | Br. J. Pharmacol. | pmid:21745193 |
| Chae HS and Chin YW | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854102 |
| Miyawaki T et al. | Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854184 |
| Kanakasabai S et al. | PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. | 2012 | PLoS ONE | pmid:23185633 |
| Kaneko K et al. | Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide. | 2012 | Neuropeptides | pmid:23141054 |
| Springstead JR et al. | Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. | 2012 | J. Lipid Res. | pmid:22550136 |
| Xue L et al. | Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2. | 2012 | J. Immunol. | pmid:22174450 |
| MartÃnez AE et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 exerts pro- and anti-inflammatory effects in mesangial cells in a concentration-dependent manner. | 2012 | Inflamm Allergy Drug Targets | pmid:22309084 |
| Fujita M et al. | Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. | 2012 | Int J Med Sci | pmid:22991494 |
| Ito H et al. | PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. | 2012 | J. Am. Soc. Nephrol. | pmid:22997255 |
| Wu CC et al. | Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22960220 |
| Song HH et al. | Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. | 2012 | Am. J. Chin. Med. | pmid:22928836 |
| Tachikawa M et al. | A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22931759 |
| Fredman G et al. | Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. | 2012 | Sci Rep | pmid:22957142 |
| Matzkin ME et al. | Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. | 2012 | Gen. Comp. Endocrinol. | pmid:22974512 |
| Myeku N et al. | cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. | 2012 | Neurosci. Lett. | pmid:22982149 |
| Mechiche H et al. | Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. | 2012 | PLoS ONE | pmid:22984630 |
| Shim J et al. | Change in prostaglandin expression levels and synthesizing activities in dry eye disease. | 2012 | Ophthalmology | pmid:22858125 |
| Kim SE et al. | 15-deoxy-Δ¹²,¹ⴠ-prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-γ and heme oxygenase-1 in rat hippocampal slices. | 2012 | J. Neurosci. Res. | pmid:22487967 |
| Garza LA et al. | Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. | 2012 | Sci Transl Med | pmid:22440736 |
| Cloutier A et al. | The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. | 2012 | J. Infect. Dis. | pmid:22219346 |
| Sykes L et al. | Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. | 2012 | Mediators Inflamm. | pmid:22690041 |
| Raman P et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22700433 |
| Cao DS et al. | Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. | 2012 | PLoS ONE | pmid:22701540 |
| Yue L et al. | Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. | 2012 | Bone | pmid:22705147 |
| Napimoga MH et al. | Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. | 2012 | J. Immunol. | pmid:22706081 |
| Rahman MS et al. | Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. | 2013 | Appl. Biochem. Biotechnol. | pmid:23817787 |
| Aldrovandi M et al. | Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. | 2013 | J. Lipid Res. | pmid:23883581 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Lu Y et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. | 2013 | Nephron Exp. Nephrol. | pmid:23887394 |
| Takayama F et al. | Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia. | 2013 | J. Neuroimmunol. | pmid:23850486 |
| Nakagawa T et al. | A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old. | 2013 | Clin. Chim. Acta | pmid:23603101 |
| Sykes L et al. | The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour. | 2013 | Immunology | pmid:23374103 |
| Nelson AM et al. | Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. | 2013 | J. Invest. Dermatol. | pmid:23190891 |
| Kaikkonen S et al. | Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. | 2013 | Mol. Endocrinol. | pmid:23192983 |
| Schmidt JA et al. | Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. | 2013 | Br. J. Pharmacol. | pmid:23146091 |
| Aukema HM et al. | Dietary fish oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. | 2013 | Br. J. Nutr. | pmid:23151363 |
| Frieri M et al. | Mast cell activation syndrome: a review. | 2013 | Curr Allergy Asthma Rep | pmid:23179866 |
| Kaur R et al. | A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds. | 2013 | J Biomol Screen | pmid:23983232 |
| Liu H et al. | Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. | 2013 | Neurotoxicology | pmid:23973622 |
| Bogacka I et al. | The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. | 2013 | Reprod Biol | pmid:24287039 |
| Mruwat R et al. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. | 2013 | PLoS ONE | pmid:24204651 |
| Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
| Sayers BC et al. | Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23642096 |
| Tan BS et al. | 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). | 2013 | Cancer Lett. | pmid:23612072 |