PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
| Higashiyama K et al. | Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. | 1996 | Prostaglandins | pmid:8908616 |
| Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
| Kennedy I et al. | Studies on the characterisation of prostanoid receptors: a proposed classification. | 1982 | Prostaglandins | pmid:6131499 |
| Kim HS et al. | Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. | 1996 | Prostaglandins | pmid:8873236 |
| Spannhake EW et al. | Bronchoactive metabolites of arachidonic acid and their role in airway function. | 1981 | Prostaglandins | pmid:6801729 |
| Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
| Claeys M et al. | Lack of prostacyclin biosynthesis by aortic tissue of the chicken. | 1981 | Prostaglandins | pmid:6803304 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Nishizawa EE et al. | Prostaglandin d2 as a potential antithrombotic agent. | 1975 | Prostaglandins | pmid:806102 |
| Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
| Karniguian A et al. | Prostaglandins: specific inhibition of platelet adhesion to collagen and relationship with cAMP level. | 1982 | Prostaglandins | pmid:6287536 |
| Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
| Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
| Ninomiya H et al. | Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage. | 1992 | Prostaglandins | pmid:1584994 |
| Lee DY et al. | Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions. | 1992 | Prostaglandins | pmid:1542741 |
| Tanaka H et al. | The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. | 1985 | Prostaglandins | pmid:3863195 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. | 1989 | Prostaglandins | pmid:2475889 |
| Roberts LJ and Sweetman BJ | Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | 1985 | Prostaglandins | pmid:3864190 |
| Foreman D et al. | Effects of E2 levuglandins on the contractile activity of the rat uterus. | 1987 | Prostaglandins | pmid:3317517 |
| Koizumi T et al. | Induction of heme oxygenase by delta 12-prostaglandin J2 in porcine aortic endothelial cells. | 1992 | Prostaglandins | pmid:1542739 |
| Black JL et al. | A comparison of the contractile activity of PGD2 and PGF2 alpha on human isolated bronchus. | 1986 | Prostaglandins | pmid:3464041 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Napier FE and Temple DM | The influence of xanthines on the contractile responses of PGF2 alpha and PGD2 in human parenchymal strips. | 1989 | Prostaglandins | pmid:2772222 |
| Gerritsen ME | PGD2 formation in the vasculature: characteristics of rat tail vein prostaglandin endoperoxide-D isomerase. | 1983 | Prostaglandins | pmid:6573722 |
| Simmet T and Jaffe BM | Inhibition of B-16 melanoma growth in vitro by prostaglandin D2. | 1983 | Prostaglandins | pmid:6573723 |
| Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
| Harris DN et al. | 9 alpha-homo-9,11-epoxy-5,13-prostadienoic acid analogues: specific stable agonist (SQ 26, 538) and antagonist (SQ 26, 536) of the human platelet thromboxane receptor. | 1981 | Prostaglandins | pmid:6270744 |
| Cebola I and Peinado MA | Epigenetic deregulation of the COX pathway in cancer. | 2012 | Prog. Lipid Res. | pmid:22580191 |
| Hemker DP and Aiken JW | Effects of prostaglandins on autonomic function in vivo, with special emphasis on PGD2 and PGD3. | 1981 | Prog. Lipid Res. | pmid:6952267 |
| Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
| Thierauch KH et al. | ZK 110 841--a selective and potent prostaglandin D2 analogue. | 1989 | Prog. Clin. Biol. Res. | pmid:2798462 |
| Philips JB and Lyrene RK | Persistent pulmonary hypertension and prostaglandin D2. | 1983 | Prog. Clin. Biol. Res. | pmid:6577475 |
| Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
| Bhattacharya SK et al. | Prostaglandin D2 mediated specific increase in rat brain serotonin. | 1985 | Proc. West. Pharmacol. Soc. | pmid:3865228 |
| Gause GE et al. | Hemodynamic effects of postpulmonary administration of prostaglandin D2 in fetal animals. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3858885 |
| Koharudin LM et al. | Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20231490 |
| Qu WM et al. | Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17093043 |
| Murata T et al. | Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23479612 |
| Ueno R et al. | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6964402 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Cheng K et al. | Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16617107 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
| Watanabe Y et al. | Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6308629 |