| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Lung Injury | D055371 | 33 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Gastrointestinal Hemorrhage | D006471 | 27 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Matsuo T et al. | 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741709 |
| Józkowicz A et al. | Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14715242 |
| Neuhofer W et al. | Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. | 2004 | Kidney Int. | pmid:14717913 |
| Ward JE et al. | PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. | 2004 | Br. J. Pharmacol. | pmid:14718259 |
| Ray DM et al. | Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. | 2004 | Clin. Immunol. | pmid:15451478 |
| Abdelrahman M et al. | The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. | 2004 | Shock | pmid:15545828 |
| Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
| Kumagai M et al. | 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. | 2004 | Tohoku J. Exp. Med. | pmid:14998300 |
| Emi M and Maeyama K | The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. | 2004 | Biochem. Pharmacol. | pmid:15013841 |
| Waits PS et al. | Nociceptin/orphanin FQ modulates human T cell function in vitro. | 2004 | J. Neuroimmunol. | pmid:15020071 |
| Azuma Y et al. | Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. | 2004 | J. Pharmacol. Sci. | pmid:15037811 |
| Diab A et al. | Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. | 2004 | J. Neuroimmunol. | pmid:14975592 |
| Paumi CM et al. | Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). | 2004 | Biochemistry | pmid:14979731 |
| Fogel-Petrovic M et al. | Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. | 2004 | Immunol. Cell Biol. | pmid:14984594 |
| Hayaishi O et al. | Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. | 2004 | Arch Ital Biol | pmid:15493554 |
| Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
| Huang H et al. | Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. | 2004 | Mol. Cancer Res. | pmid:15498928 |
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| Higashihara H et al. | Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. | 2004 | Redox Rep. | pmid:15720834 |
| Takagi T et al. | A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. | 2004 | Redox Rep. | pmid:15720836 |
| Blázovics A et al. | [Cytokines, prostaglandins, nutritive and non-nuitritive factors in inflammatory bowel diseases]. | 2004 | Orv Hetil | pmid:15662752 |
| Trottein F et al. | Role of the D prostanoid receptor 1 in the modulation of immune and inflammatory responses. | 2004 | Crit. Rev. Immunol. | pmid:15663363 |
| Yuan Z et al. | Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells. | 2004 | J. Cardiovasc. Pharmacol. | pmid:15167281 |
| Lee KJ et al. | Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. | 2004 | Exp. Mol. Med. | pmid:15665586 |
| Dahlén SE and Kumlin M | Monitoring mast cell activation by prostaglandin D2 in vivo. | 2004 | Thorax | pmid:15170020 |
| Bochenek G et al. | Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. | 2004 | Thorax | pmid:15170023 |
| Zhang X et al. | Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. | 2004 | Kidney Int. | pmid:14871400 |
| Ueta M et al. | PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. | 2004 | Kidney Int. | pmid:14871416 |
| Weber SM et al. | PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:14600076 |
| Asada K et al. | Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14563653 |
| Reddy PS et al. | The synthesis and effects of prostaglandins on the ovary of the crab Oziotelphusa senex senex. | 2004 | Gen. Comp. Endocrinol. | pmid:14644642 |
| Siavash H et al. | Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. | 2004 | Br. J. Cancer | pmid:15316561 |
| Sánchez-Gómez FJ et al. | Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes. | 2004 | Mol. Pharmacol. | pmid:15317873 |
| Shahab R et al. | Prostaglandins, leukotrienes and perennial rhinitis. | 2004 | J Laryngol Otol | pmid:15318955 |
| Lim SY et al. | 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. | 2004 | J. Biol. Chem. | pmid:15319433 |
| Sasaguri T and Miwa Y | Prostaglandin J2 family and the cardiovascular system. | 2004 | Curr Vasc Pharmacol | pmid:15320511 |
| Servidei T et al. | The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines. | 2004 | Oncol. Res. | pmid:15301425 |
| Boyault S et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. | 2004 | FEBS Lett. | pmid:15304320 |
| Ichiki T et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369766 |
| Schlezinger JJ et al. | Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. | 2004 | J. Immunol. | pmid:15322177 |
| Si Q et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. | 2004 | J. Immunol. | pmid:15322215 |
| Cheng J et al. | Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15325252 |
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| Fernández-Tome M et al. | p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15249196 |
| Takeshita K et al. | CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. | 2004 | Int. Immunol. | pmid:15173122 |
| Cipollone F et al. | Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15155382 |
| Ward C et al. | Regulation of granulocyte apoptosis by NF-kappaB. | 2004 | Biochem. Soc. Trans. | pmid:15157161 |
| Miwa Y et al. | Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15158456 |
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| Piliponsky AM et al. | Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. | 2003 | Blood | pmid:12393403 |
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| Tanaka H et al. | Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria. | 2003 | Pharmacology | pmid:12571412 |
| Söderström M et al. | Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. | 2003 | Biochim. Biophys. Acta | pmid:12573447 |
| Gibbons H et al. | Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. | 2003 | Brain Res. Mol. Brain Res. | pmid:12573534 |
| Patel HJ et al. | Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. | 2003 | J. Immunol. | pmid:12594295 |
| Badawi AF and Badr MZ | Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. | 2003 | Int. J. Cancer | pmid:12455057 |
| Weber SM et al. | Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12517740 |
| Hashimoto T et al. | Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. | 2003 | J Ocul Pharmacol Ther | pmid:14733714 |