PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walther U et al. | Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway. | 2016 | Oncotarget | pmid:26863638 |
| Matzkin ME et al. | Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes. | 2016 | Aging (Albany NY) | pmid:26805572 |
| Koyani CN et al. | Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. | 2016 | Biochem. Pharmacol. | pmid:26801686 |
| Jandl K et al. | Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung. | 2016 | J. Allergy Clin. Immunol. | pmid:26792210 |
| Shirley D et al. | Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells. | 2016 | Biochim. Biophys. Acta | pmid:26777630 |
| Figueiredo-Pereira ME et al. | Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. | 2016 | Ann. N. Y. Acad. Sci. | pmid:26748744 |
| Flores JJ et al. | PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats. | 2016 | Neurobiol. Dis. | pmid:26739391 |
| Vishwakarma P et al. | 15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis. | 2016 | J. Mol. Med. | pmid:26830627 |
| Wallace DI et al. | A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2. | 2016 | Comput Math Methods Med | pmid:28044089 |
| Kida T et al. | Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. | 2016 | PLoS ONE | pmid:27992456 |
| Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
| Le Loupp AG et al. | [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. | 2015 Jun-Jul | Med Sci (Paris) | pmid:26152165 |
| Li P et al. | [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679661 |
| Benedetti F and Dogue S | Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. | 2015 | PLoS ONE | pmid:26536471 |
| Li XY et al. | 15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation. | 2015 | Genet. Mol. Res. | pmid:26535717 |
| Oishi Y et al. | The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. | 2015 | Brain Behav. Immun. | pmid:25532785 |
| Fukuoka T et al. | Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ. | 2015 | Int. J. Cancer | pmid:25516376 |
| Xue L et al. | Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk. | 2015 | J. Allergy Clin. Immunol. | pmid:25441644 |
| Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
| Willenberg I et al. | Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). | 2015 | J Chromatogr A | pmid:25777050 |