PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Kidney Failure, Chronic D007676 51 associated lipids
Asthma D001249 52 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
Weight Loss D015431 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Neuroblastoma D009447 66 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Leukemia D007938 74 associated lipids
Stomach Ulcer D013276 75 associated lipids
Alzheimer Disease D000544 76 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
pmid:24471457
pmid:24456221
pmid:24352801
pmid:25907057
pmid:27271931
pmid:27140063
pmid:28262205
pmid:28195470
pmid:28174214
pmid:27055381
pmid:27050800
pmid:27032756
pmid:26999671
pmid:25964109
pmid:
Korbecki J et al. Cyclooxygenase pathways. 2014 Acta Biochim. Pol. pmid:25343148
Jozkowicz A et al. Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages. 2000 Acta Biochim. Pol. pmid:11996104
Józkowicz A et al. Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. 2003 Acta Biochim. Pol. pmid:14515149
Satoh T et al. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. 2010 Acta Derm. Venereol. pmid:20107720
Wogensen L and Warberg J Effect of prostaglandin D2 on the release of luteinizing hormone and prolactin in castrated and intact male rats. 1986 Acta Endocrinol. pmid:3461657
Miyake A et al. Prostaglandin D2 stimulates secretion of luteinizing hormone from pituitary gland in vitro. 1983 Acta Endocrinol. pmid:6579807
Smith JB Prostaglandins and platelet aggregation. 1981 Acta Med. Scand. Suppl. pmid:7034481
Yang KD et al. A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. 1995 Acta Microbiol Immunol Hung pmid:8689093
Łazarewicz JW et al. NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo. 2000 Acta Neurobiol Exp (Wars) pmid:11200170
Gaetani P et al. Ex vivo release of eicosanoids after aneurysmal subarachnoid hemorrhage: a preliminary experience in humans. 1992 Acta Neurol. Scand. pmid:1414230
Rodriguez R et al. Effect of nimodipine on arachidonic acid metabolites after subarachnoid hemorrhage. 1987 Acta Neurol. Scand. pmid:3120489
Dong YG et al. Effects of 15-deoxy-delta12,14-prostaglandin J2 on cell proliferation and apoptosis in ECV304 endothelial cells. 2004 Acta Pharmacol. Sin. pmid:14704122
Sun K et al. PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. 2006 Acta Pharmacol. Sin. pmid:16723090
Wang WM et al. PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. 2009 Acta Pharmacol. Sin. pmid:19098936
Korbut R and Gryglewski RJ Anti-aggregatory prostanoids. Part I. 1985 Sep-Dec Acta Physiol Pol pmid:3915631
Brus R et al. Effect of prostaglandins on morphine-induced catalepsy in mice. 1983 Sep-Dec Acta Physiol Pol pmid:6679984
Diener M et al. Characterization of the antisecretory action of prostaglandin D2 in the rat colon. 1992 Acta Physiol. Scand. pmid:1502910
Tamaoki J et al. Prostaglandin D2 increases Cl secretion across canine tracheal epithelium through cyclo-oxygenase stimulation and cAMP production. 1992 Acta Physiol. Scand. pmid:1323920
Diener M and Gabato D Thromboxane-like actions of prostaglandin D2 on the contractility of the rat colon in vitro. 1994 Acta Physiol. Scand. pmid:8135127
Alving K et al. The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. 1991 Acta Physiol. Scand. pmid:1957709
Eriksson LO et al. Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography. 1990 Acta Physiol. Scand. pmid:2173350
Drummond WH Persistent pulmonary hypertension of the neonate (persistent fetal circulation syndrome). 1983 Adv Pediatr pmid:6424420
Fukushima S et al. Preparation and evaluation of o/w type emulsions containing antitumor prostaglandin. 2000 Adv. Drug Deliv. Rev. pmid:11104898
Hayaishi O Tryptophan, oxygenase, and sleep. 1996 Adv. Exp. Med. Biol. pmid:8906236
Herschman HR Function and regulation of prostaglandin synthase 2. 1999 Adv. Exp. Med. Biol. pmid:10667302
Murakami M et al. Regulation of prostaglandin, leukotriene, and platelet-activating factor metabolism in mast cells. 1999 Adv. Exp. Med. Biol. pmid:10667307
Diaz BL et al. Participation of cytosolic phospholipase A2 in eicosanoid generation by mouse bone marrow-derived mast cells. 2002 Adv. Exp. Med. Biol. pmid:12664562
Hammarstrom S et al. Novel eicosanoid activators of PPAR gamma formed by RAW 264.7 macrophage cultures. 2002 Adv. Exp. Med. Biol. pmid:12664608
Lu S et al. Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes. 2003 Adv. Exp. Med. Biol. pmid:12751756
Whittle BJ et al. Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. 1985 Adv. Exp. Med. Biol. pmid:2871707
Marone G et al. Role of human mast cells and basophils in bronchial asthma. 2005 Adv. Immunol. pmid:16227089
Hayaishi O and Matsumura H Prostaglandins and sleep. 1995 Adv. Neuroimmunol. pmid:7496614
Tachikawa M et al. Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers. 2014 Adv. Pharmacol. pmid:25307222
Wolfe LS et al. Synthesis and functions of cyclooxygenase and lipoxygenase products in brain: new findings and an appraisal. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2568735
Omini C et al. Prostaglandin D2 and the cholinergic system in guinea pig airways. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823557