PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ricart KC et al. | The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. | 2009 | Biochem. J. | pmid:19161347 |
| Lee DR et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. | 2009 | Toxicology | pmid:19167456 |
| Quarello E and Trabbia A | High-definition flow combined with spatiotemporal image correlation in the diagnosis of fetal coarctation of the aorta. | 2009 | Ultrasound Obstet Gynecol | pmid:19194864 |
| Ishii T et al. | Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. | 2009 | Blood | pmid:19196660 |
| Passeron T et al. | Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. | 2009 | J. Clin. Invest. | pmid:19273910 |
| Yuan ZB et al. | Temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. | 2009 | Inflamm. Res. | pmid:19184357 |
| Whelan CJ | Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. | 2009 | Inflamm. Res. | pmid:19184361 |
| Liu J et al. | Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. | 2009 | Shock | pmid:19174742 |
| Kolaczkowska E et al. | Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. | 2009 | Immunology | pmid:19175797 |
| Joo M et al. | Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19181746 |
| Gao W et al. | Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2). | 2009 | Eur. J. Pharmacol. | pmid:19249295 |
| Wang Y et al. | Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat model. | 2009 | Pediatr. Res. | pmid:19262292 |
| Yamamoto M et al. | Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. | 2009 | Int. Arch. Allergy Immunol. | pmid:18802357 |
| Iinuma K et al. | Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. | 2009 | J. Invest. Dermatol. | pmid:19282842 |
| Ferguson HE et al. | Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. | 2009 | Am. J. Respir. Cell Mol. Biol. | pmid:19286977 |
| Xue L et al. | Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells. | 2009 | Clin. Exp. Immunol. | pmid:19220324 |
| Ono E et al. | Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis. | 2009 | Clin. Exp. Allergy | pmid:19128354 |
| Shin SW et al. | 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. | 2009 | Clin. Cancer Res. | pmid:19690198 |
| Wendeburg L et al. | Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. | 2009 | J Neuroinflammation | pmid:19751497 |
| Ferguson HE et al. | Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19734319 |
| Kim DH et al. | Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723057 |
| Song NY et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723058 |
| Cha B et al. | 15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723089 |
| Hokari R et al. | Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. | 2009 | J. Pathol. | pmid:19768745 |
| Urade Y | [Molecular mechanisms of insomnia]. | 2009 | Nippon Rinsho | pmid:19768929 |
| Ma XM et al. | Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. | 2009 | World J. Gastroenterol. | pmid:19701967 |
| Wang WM et al. | PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. | 2009 | Acta Pharmacol. Sin. | pmid:19098936 |
| Waku T et al. | Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. | 2009 | FEBS Lett. | pmid:19101554 |
| Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |
| Dong YW et al. | Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. | 2009 | World J. Gastroenterol. | pmid:19152448 |
| Koinuma S et al. | The resetting of the circadian rhythm by Prostaglandin J2 is distinctly phase-dependent. | 2009 | FEBS Lett. | pmid:19111547 |
| Baregamian N et al. | PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19114032 |
| Byrns MC and Penning TM | Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. | 2009 | Chem. Biol. Interact. | pmid:19010312 |
| Higdon AN et al. | Methods for imaging and detecting modification of proteins by reactive lipid species. | 2009 | Free Radic. Biol. Med. | pmid:19446632 |
| Kar R et al. | A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. | 2009 | Oncogene | pmid:19448671 |
| Zhang GY et al. | Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. | 2009 | Arch. Dermatol. Res. | pmid:19466435 |
| Ulbrich SE et al. | Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. | 2009 | Reproduction | pmid:19470711 |
| Bernardo A et al. | Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. | 2009 | J. Neuropathol. Exp. Neurol. | pmid:19535992 |
| Comabella M et al. | Plasma levels of 15d-PGJ are not altered in multiple sclerosis. | 2009 | Eur. J. Neurol. | pmid:19538219 |
| Qin HD et al. | Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. | 2009 | J. Cell. Physiol. | pmid:19562688 |
| Leduc M et al. | Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19584306 |
| Bai G et al. | Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. | 2009 | Peptides | pmid:19539681 |
| Pierre SR et al. | Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. | 2009 | J Neuroinflammation | pmid:19630993 |
| Pena-dos-Santos DR et al. | Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. | 2009 | Neuroscience | pmid:19647045 |
| Asano S et al. | Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19616422 |
| Gao W et al. | Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. | 2009 | J. Physiol. Pharmacol. | pmid:19617658 |
| Butterfield JH | Survey of aspirin administration in systemic mastocytosis. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19429499 |
| Moniot B et al. | The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. | 2009 | Development | pmid:19429785 |
| Relic B et al. | Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. | 2009 | Lab. Invest. | pmid:19434061 |
| Jung WK et al. | The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. | 2009 | Life Sci. | pmid:19409914 |
| Strakhova MI et al. | In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. | 2009 | Br. J. Pharmacol. | pmid:19413570 |
| Hironaka A et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19799872 |
| Ohinata K et al. | Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19800413 |
| Tagen M et al. | Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. | 2009 | J. Immunol. | pmid:19846869 |
| Prakash J et al. | Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. | 2009 | Neoplasia | pmid:20019843 |
| Khanim FL et al. | Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. | 2009 | PLoS ONE | pmid:19997560 |
| Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
| Kalogeromitros D et al. | A quercetin containing supplement reduces niacin-induced flush in humans. | 2008 Jul-Sep | Int J Immunopathol Pharmacol | pmid:18831918 |
| Papageorgiou E et al. | Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. | 2008 Jul-Aug | Mol. Med. | pmid:18475308 |
| Pettipher R and Hansel TT | Antagonists of the prostaglandin D2 receptor CRTH2. | 2008 Jul-Aug | Drug News Perspect. | pmid:18836589 |
| Takahashi N et al. | Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. | 2008 Jul-Aug | Channels (Austin) | pmid:18769139 |
| Tokuda H et al. | Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771907 |
| Dang HT et al. | New jasmonate analogues as potential anti-inflammatory agents. | 2008 | Bioorg. Med. Chem. | pmid:18996699 |
| Adler DH et al. | Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. | 2008 | J. Clin. Invest. | pmid:18451993 |
| Poncin S et al. | Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. | 2008 | Endocrinology | pmid:17884933 |
| Toscano CD et al. | NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. | 2008 | Neurotoxicology | pmid:18834901 |
| Royer JF et al. | A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils. | 2008 | Eur. J. Clin. Invest. | pmid:18837743 |
| Yamamoto Y et al. | Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. | 2008 | J. Gastroenterol. Hepatol. | pmid:18565023 |
| Panzer U et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells. | 2008 | Nephrol. Dial. Transplant. | pmid:18596134 |
| Payne CA et al. | Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. | 2008 | Mol. Cancer Ther. | pmid:18852145 |
| Moon TC and Befus AD | Exogenous nitric oxide regulates cyclooxygenase-2 expression and prostaglandin D(2) generation through p38 MAPK in mouse bone marrow-derived mast cells. | 2008 | Free Radic. Biol. Med. | pmid:18598759 |
| Su RY et al. | 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. | 2008 | Mol. Cancer Ther. | pmid:18852146 |
| Kim HY et al. | Upregulation of lipopolysaccharide-induced interleukin-10 by prostaglandin A1 in mouse peritoneal macrophages. | 2008 | J. Microbiol. Biotechnol. | pmid:18600064 |
| Oguma T et al. | Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma. | 2008 | Allergol Int | pmid:18946232 |
| Lee SJ et al. | 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis via JNK-mediated mitochondrial pathway in osteoblastic cells. | 2008 | Toxicology | pmid:18450357 |
| Moniot B et al. | Male specific expression of lipocalin-type prostaglandin D synthase (cPTGDS) during chicken gonadal differentiation: relationship with cSOX9. | 2008 | Sex Dev | pmid:18577876 |
| Nagata D et al. | Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. | 2008 | Cancer Detect. Prev. | pmid:18789607 |
| Amir-Moazami O et al. | Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. | 2008 | J. Biol. Chem. | pmid:18579528 |
| Yoshimura T et al. | Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. | 2008 | Allergol Int | pmid:18797183 |
| Chearwae W and Bright JJ | 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. | 2008 | J. Clin. Immunol. | pmid:18463970 |
| Maruyama T et al. | Prostaglandin D(2) induces contraction via thromboxane A(2) receptor in rat liver myofibroblasts. | 2008 | Eur. J. Pharmacol. | pmid:18586024 |
| Papaliodis D et al. | Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18784348 |
| Niemoeller OM et al. | Ciglitazone and 15d-PGJ2 induced suicidal erythrocyte death. | 2008 | Cell. Physiol. Biochem. | pmid:18769050 |
| Kim EH and Surh YJ | The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis. | 2008 | Biochem. Pharmacol. | pmid:18771658 |
| Kim JW et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. | 2008 | Biochem. Pharmacol. | pmid:18775681 |
| Kuehn HS et al. | The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. | 2008 | J. Immunol. | pmid:19017959 |
| Ho TC et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. | 2008 | J. Biol. Chem. | pmid:18718914 |
| Chearwae W and Bright JJ | PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells. | 2008 | Br. J. Cancer | pmid:19018263 |
| Chan BC et al. | Traditional Chinese medicine for atopic eczema: PentaHerbs formula suppresses inflammatory mediators release from mast cells. | 2008 | J Ethnopharmacol | pmid:18725279 |
| Patel P et al. | Enantio- and stereospecific syntheses of 15(R)-Me-PGD2, a potent and selective DP2-receptor agonist. | 2008 | J. Org. Chem. | pmid:18700746 |
| Le Mée S et al. | 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. | 2008 | Steroids | pmid:18555503 |
| Uchida K and Shibata T | 15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses. | 2008 | Chem. Res. Toxicol. | pmid:18052108 |
| Yu JH et al. | SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18035585 |
| Yokoi H et al. | Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. | 2008 | J. Allergy Clin. Immunol. | pmid:18036650 |
| Kuboki S et al. | Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice. | 2008 | Hepatology | pmid:18085707 |
| Shefler I et al. | Inhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides. | 2008 | Int. Arch. Allergy Immunol. | pmid:17848806 |
| Li W et al. | Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture. | 2008 | Neurochem. Res. | pmid:17763946 |
| Moon TC et al. | The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2008 | Arch. Pharm. Res. | pmid:18365692 |
| Kimura H et al. | A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. | 2008 | Nephrol. Dial. Transplant. | pmid:18367541 |
| Paruchuri S et al. | Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. | 2008 | J. Biol. Chem. | pmid:18411276 |