Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Barnea A et al. | Evidence that a short-lived effect of copper leads to amplification of prostaglandin E2 stimulation of the release of gonadotropin-releasing hormone from median eminence explants. | 1986 | Endocrinology | pmid:3525128 |
Viganò T et al. | Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-immunological challenge of human lung parenchyma "in vitro". | 1986 | Prostaglandins Leukot Med | pmid:3020580 |
Koshihara Y and Kawamura M | Inhibitory effect of prostaglandin D2 on DNA synthesis in nuclei. | 1986 | Prostaglandins Leukot Med | pmid:3020589 |
Jaschonek K et al. | The binding of 6-oxo-prostaglandin E1 to platelet prostanoid receptors. | 1986 | Prostaglandins Leukot Med | pmid:3020591 |
Inokuchi A and Oomura Y | Effects of prostaglandin D2 on the activity of hypothalamic neurons in the rat. | 1986 | Jpn. J. Physiol. | pmid:3022048 |
Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
Hickok NJ et al. | Characterization of prostaglandin endoperoxide synthase from a human cell line. | 1986 | Biochim. Biophys. Acta | pmid:3087430 |
Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
Ohno K et al. | Metabolic dehydration of prostaglandin E2 and cellular uptake of the dehydration product: correlation with prostaglandin E2-induced growth inhibition. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3464277 |
MacIntyre DE et al. | Receptors and receptor mechanisms of endogenous platelet stimulatory and inhibitory mediators. | 1986 | Agents Actions Suppl. | pmid:3028106 |
Tanaka A et al. | Antiherpetic action of prostaglandin D2. | 1986 | Prostaglandins Leukot Med | pmid:3029784 |
Peters SP et al. | Mediator release from human lung under conditions of reduced oxygen tension. | 1986 | J. Pharmacol. Exp. Ther. | pmid:2425080 |
Wells E et al. | Characterization of primate bronchoalveolar mast cells. I. IgE-dependent release of histamine, leukotrienes, and prostaglandins. | 1986 | J. Immunol. | pmid:2431048 |
MacDermot J | Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo. | 1986 | Biochem. Pharmacol. | pmid:2427086 |
Heavey DJ et al. | Prostaglandin D2 and histamine release in cold urticaria. | 1986 | J. Allergy Clin. Immunol. | pmid:2428856 |
Suzuki H et al. | [Inhibition of growth of human endometrial adenocarcinoma cells in vitro treated with prostaglandin F2 alpha, E2, D2 and J2]. | 1986 | Nihon Naibunpi Gakkai Zasshi | pmid:3465609 |
Eady RP | The pharmacology of nedocromil sodium. | 1986 | Eur J Respir Dis Suppl | pmid:2429854 |
Kleeberger SR et al. | Central role of cyclooxygenase in the response of canine peripheral airways to antigen. | 1986 | J. Appl. Physiol. | pmid:2430928 |
Wells E et al. | Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mast cells. | 1986 | J. Immunol. | pmid:2431049 |
Ashby B | Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes. | 1986 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2432105 |
Koro O et al. | Release of prostaglandin D2 and histamine in a case of localized heat urticaria, and effect of treatments. | 1986 | Br. J. Dermatol. | pmid:2432916 |
Watanabe K | [PGF synthetase]. | 1986 | Seikagaku | pmid:3084680 |
Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
Kriseman T et al. | Analysis of airway responses to A23187 in the cat. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3095538 |
Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
Narumiya S and Fukushima M | Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3772804 |
Narumiya S et al. | Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3772805 |
Bregman MD et al. | Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. | 1986 | Cancer Res. | pmid:3698005 |
Kato T et al. | Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. | 1986 | Cancer Res. | pmid:3708585 |
Keeting PE et al. | Rat lens prostaglandin biosynthesis during galactose-induced cataractogenesis. | 1986 | Exp. Eye Res. | pmid:3028846 |
Horiguchi S et al. | Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. | 1986 | Eur. J. Pharmacol. | pmid:3458588 |
Bhuyan BK et al. | Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. | 1986 | Cancer Res. | pmid:3456266 |
Brooks DP et al. | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. | 1986 | Endocrinology | pmid:3456303 |
Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
Barnes VF and Heavey DJ | Effect of prostaglandin D2 on histamine-induced weals in human skin. | 1986 | Br. J. Pharmacol. | pmid:3456816 |
Gaetani P et al. | Prostaglandin D2 monitoring in human CSF after subarachnoid hemorrhage: the possible role of prostaglandin D2 in the genesis of cerebral vasospasm. | 1986 | Ital J Neurol Sci | pmid:3456998 |
Sugiyama T et al. | Platelet prostaglandin D2 dehydrogenase in patients with myeloproliferative disorders. | 1986 | Prostaglandins Leukot Med | pmid:3457389 |
Omini C et al. | Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea. | 1986 | J Auton Pharmacol | pmid:3464602 |
Kikuchi Y et al. | Inhibition of human ovarian cancer cell growth in vitro and in nude mice by prostaglandin D2. | 1986 | Cancer Res. | pmid:3458525 |
Hamilton RG et al. | Dirofilaria immitis: diethylcarbamazine-induced anaphylactoid reactions in infected dogs. | 1986 | Exp. Parasitol. | pmid:3458592 |
Nakagawa Y et al. | [Effect of prostaglandin D2 on the growth of mouse glioma]. | 1986 | Gan To Kagaku Ryoho | pmid:3459395 |
Naclerio R et al. | The role of inflammatory mediators in allergic rhinitis. | 1986 | Ear Nose Throat J | pmid:3459645 |
Wogensen L and Warberg J | Effect of prostaglandin D2 on the release of luteinizing hormone and prolactin in castrated and intact male rats. | 1986 | Acta Endocrinol. | pmid:3461657 |
Murray JJ et al. | Release of prostaglandin D2 into human airways during acute antigen challenge. | 1986 | N. Engl. J. Med. | pmid:3462506 |
Honda C and Tabuchi K | [Effects of prostaglandin D2 on cultured glioma cells]. | 1986 | Gan To Kagaku Ryoho | pmid:3463248 |
Nelson CA and Seamon KB | Binding of [3H]forskolin to human platelet membranes. Regulation by guanyl-5'-yl imidodiphosphate, NaF, and prostaglandins E1 and D2. | 1986 | J. Biol. Chem. | pmid:3463564 |
Makhoul RG and Gewertz BL | Renal prostaglandins. | 1986 | J. Surg. Res. | pmid:3511324 |
Dutta-Roy AK et al. | Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. | 1986 | Science | pmid:3001935 |