Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hardy E et al. | Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. | 1995 | Thromb. Haemost. | pmid:8560425 |
Osaka T and Hayaishi O | Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. | 1995 | Neurosci. Res. | pmid:8545074 |
Daugschies A | Oesophagostomum dentatum: population dynamics and synthesis of prostanoids by histotropic stages cultured in vitro. | 1995 | Exp. Parasitol. | pmid:8542999 |
Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |
Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
Itabashi S et al. | Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. | 1993 | Int. Arch. Allergy Immunol. | pmid:8508057 |
Rangachari PK and Betti PA | Biological activity of metabolites of PGD2 on canine proximal colon. | 1993 | Am. J. Physiol. | pmid:8498516 |
Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
Fredberg JJ et al. | Tissue resistance and the contractile state of lung parenchyma. | 1993 | J. Appl. Physiol. | pmid:8482682 |
Kim IK et al. | Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells. | 1993 | FEBS Lett. | pmid:8477853 |
Wegner CD et al. | The role of 5-lipoxygenase products in preclinical models of asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8473681 |
Johnston SL et al. | The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage. | 1993 | J. Allergy Clin. Immunol. | pmid:8473679 |
Morrow JD and Minton TA | Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography-mass spectrometry. | 1993 | J. Chromatogr. | pmid:8468374 |
Barski OA and Watanabe K | Kinetic mechanism of ketoreductase activity of prostaglandin F synthase from bovine lung. | 1993 | FEBS Lett. | pmid:8458424 |
Woodward DF et al. | Further studies on ocular responses to DP receptor stimulation. | 1993 | Eur. J. Pharmacol. | pmid:8440310 |
Hallbrucker C et al. | Hydroperoxide metabolism in rat liver. K+ channel activation, cell volume changes and eicosanoid formation. | 1993 | Eur. J. Biochem. | pmid:8436107 |
Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
Neuschäfer-Rube F et al. | Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. | 1993 | Eur. J. Biochem. | pmid:8425526 |