PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Black PN et al. | Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. | 1989 | Thorax | pmid:2548300 |
| Montuschi P et al. | Exhaled leukotrienes and prostaglandins in COPD. | 2003 | Thorax | pmid:12832671 |
| Yokoyama Y et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. | 2010 | Ther Apher Dial | pmid:20438519 |
| Shiraki T et al. | [Activation mechanism of PPARgamma by its endogenous ligands]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16277244 |
| Fukushima M | [Prostaglandins and cell proliferation]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024021 |
| Tanaka H et al. | [Synthesis of chemical probes based on combinatorial chemistry and lab automation]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051395 |
| Urade Y | [Structure and function of prostaglandin D synthase]. | 2008 | Tanpakushitsu Kakusan Koso | pmid:18326294 |
| Satoh T and Watanabe Y | [Cyclopentenone prostaglandin derivatives as neuroprotective compounds]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:12486935 |
| Stringfellow DA | Prostaglandins and metastasis. | 1983 | Symp Fundam Cancer Res | pmid:6206537 |
| Farrow B et al. | Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. | 2003 | Surgery | pmid:12947319 |
| Yoshida T et al. | Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer. | 1998 | Surg. Today | pmid:9697269 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
| Gaetani P et al. | Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats. | 1991 | Stroke | pmid:1900645 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| Blanco M et al. | Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. | 2005 | Stroke | pmid:15879329 |
| Xu X et al. | Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. | 2013 | Steroids | pmid:23707573 |
| Le Mée S et al. | 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. | 2008 | Steroids | pmid:18555503 |
| Tang J et al. | Aspirin treatment improved mesenchymal stem cell immunomodulatory properties via the 15d-PGJ2/PPARγ/TGF-β1 pathway. | 2014 | Stem Cells Dev. | pmid:24730450 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep/wake regulation. | 2011 | Sleep Med Rev | pmid:22024172 |