PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Lymphoma, T-Cell D016399 11 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Coronavirus Infections D018352 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Cystitis, Interstitial D018856 2 associated lipids
Optic Neuropathy, Ischemic D018917 2 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Thrombophilia D019851 6 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Stroke D020521 32 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Fetal Weight D020567 12 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Coronary Restenosis D023903 10 associated lipids
Tauopathies D024801 6 associated lipids
Mastocytosis, Systemic D034721 1 associated lipids
Decapitation D049248 2 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Angioedemas, Hereditary D054179 2 associated lipids
Idiopathic Pulmonary Fibrosis D054990 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
Pulmonary Aspergillosis D055732 1 associated lipids
Asthma, Aspirin-Induced D055963 2 associated lipids
Airway Remodeling D056151 3 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Equils O et al. Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. 2001 J. Immunol. pmid:11160291
Kitamura Y et al. Effects of 15-deoxy-delta(12,14) prostaglandin J(2) and interleukin-4 in Toll-like receptor-4-mutant glial cells. 2001 Eur. J. Pharmacol. pmid:11164379
Kadekaro M et al. Central interactions between angiotensin II and PGD(2) in the regulation of vasopressin and oxytocin secretion in dehydrated rats. 2001 Brain Res. pmid:11166690
Wilmer WA et al. A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma. 2001 Biochem. Biophys. Res. Commun. pmid:11178960
Łazarewicz JW et al. NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo. 2000 Acta Neurobiol Exp (Wars) pmid:11200170
Inoue T et al. Serum prostaglandin D synthase level after coronary angioplasty may predict occurrence of restenosis. 2001 Thromb. Haemost. pmid:11204569
Hirai H et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. 2001 J. Exp. Med. pmid:11208866
Tunaz H et al. Prostaglandin biosynthesis by fat body from true armyworms, Pseudaletia unipuncta. 2001 Insect Biochem. Mol. Biol. pmid:11222953
Reilly CM et al. Prostaglandin J(2) inhibition of mesangial cell iNOS expression. 2001 Clin. Immunol. pmid:11237557
Szczeklik A et al. Safety of a specific COX-2 inhibitor in aspirin-induced asthma. 2001 Clin. Exp. Allergy pmid:11251623
Kang SS et al. Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix. 2001 Chem. Pharm. Bull. pmid:11253924
Okayama Y et al. A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. 2001 J. Immunol. pmid:11254731
Fahmi H et al. Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. 2001 Arthritis Rheum. pmid:11263774
Thévenon C et al. Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine. 2001 Clin. Chem. pmid:11274037
Rohn TT et al. 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. 2001 Neuroreport pmid:11277593
Satoh T et al. Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins. 2001 J. Neurochem. pmid:11279261
Drew PD and Chavis JA The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. 2001 J. Neuroimmunol. pmid:11282151
Wang C et al. Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. 2001 Mol. Cell. Biol. pmid:11287611
Jiang JG et al. Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element. 2001 J. Biol. Chem. pmid:11292834
Niyonsaba F et al. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. 2001 Eur. J. Immunol. pmid:11298331