PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnston DE and Kroening C | Stimulation of prostaglandin synthesis in cultured liver cells by CCl4. | 1996 | Hepatology | pmid:8781342 |
| Rozera C et al. | Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. | 1996 | J. Clin. Invest. | pmid:8621762 |
| Seghaye MC et al. | Histamine liberation related to cardiopulmonary bypass in children: possible relation to transient postoperative arrhythmias. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8622322 |
| Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
| Chilton FH et al. | Antigen-induced generation of lyso-phospholipids in human airways. | 1996 | J. Exp. Med. | pmid:8642333 |
| Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
| Odani N et al. | Induction of protein disulfide isomerase mRNA by delta 12-prostaglandin J2. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645293 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Weidenbach H et al. | Reduction of bile secretion by prostaglandins in the rat in vivo. | 1996 | Life Sci. | pmid:8649182 |
| Satoh S et al. | Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8650205 |
| Hayaishi O | Tryptophan, oxygenase, and sleep. | 1996 | Adv. Exp. Med. Biol. | pmid:8906236 |
| Urade Y et al. | Molecular mechanism of sleep regulation by prostaglandin D2. | 1996 | J Lipid Mediat Cell Signal | pmid:8906548 |
| Higashiyama K et al. | Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. | 1996 | Prostaglandins | pmid:8908616 |
| Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
| Ko FN et al. | Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. | 1996 | J. Pharm. Pharmacol. | pmid:8794990 |
| Santos J et al. | Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. | 1996 | Gastroenterology | pmid:8942724 |
| Woodiel FN et al. | Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway. | 1996 | J. Bone Miner. Res. | pmid:8864899 |
| Knol EF et al. | The role of basophils in allergic disease. | 1996 | Eur Respir J Suppl | pmid:8871057 |
| Obata T et al. | IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780726 |
| Kim HS et al. | Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. | 1996 | Prostaglandins | pmid:8873236 |
| Naclerio RM et al. | Origin of late phase histamine release. | 1996 | J. Allergy Clin. Immunol. | pmid:8876545 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| de Graaf-in t Veld C et al. | Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls. | 1996 | Clin. Exp. Allergy | pmid:8877155 |
| Ashraf MM et al. | Type II phospholipase A2 is linked to cyclooxygenase-2-mediated delayed prostaglandin D2 generation by cultured mouse mast cells following FcepsilonRI- and cytokine-dependent activation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954964 |
| Patella V et al. | Eosinophil granule proteins activate human heart mast cells. | 1996 | J. Immunol. | pmid:8757629 |
| Bingham CO et al. | A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. | 1996 | J. Biol. Chem. | pmid:8824228 |
| Sharif NA et al. | Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819509 |
| Chung HS et al. | Heat contact urticaria--a case report. | 1996 | Yonsei Med. J. | pmid:8826790 |
| Conti C et al. | Inhibition of poliovirus replication by prostaglandins A and J in human cells. | 1996 | Antimicrob. Agents Chemother. | pmid:8834882 |
| McClay EF et al. | delta 12-Prostaglandin-J2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation. | 1996 | Cancer Res. | pmid:8752147 |
| Franzese O et al. | Functional antagonism between IL-2 and PGA1 or PGJ2 in the control of proliferation of human cord blood-derived mononuclear cells. | 1996 | Int. J. Immunopharmacol. | pmid:9089005 |
| Norwitz ER et al. | Prostaglandin production by human peripheral blood monocytes changes with in vitro differentiation. | 1996 | Prostaglandins | pmid:8792444 |
| Odani N et al. | Regulation of BiP gene expression by cyclopentenone prostaglandins through unfolded protein response element. | 1996 | J. Biol. Chem. | pmid:8663202 |
| Shiroma T et al. | [Production and metabolism of prostaglandin D2 by cultured chick retinal pigment epithelial cells]. | 1996 | Nippon Ganka Gakkai Zasshi | pmid:8741332 |
| Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
| Sakai T | [Molecular cancer epidemiology--the present status and future possibilities]. | 1996 | Nihon Eiseigaku Zasshi | pmid:8720930 |
| Shalev A and Meier CA | Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis. | 1996 | Eur. J. Endocrinol. | pmid:8664970 |
| Vedin I et al. | Stimulation of tumor necrosis factor-alpha release from lipopolysaccharide-activated human blood monocytes by prostaglandin J2 and metabolites of prostaglandin J2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931117 |
| de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
| Ashraf M et al. | Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1 beta in mouse cultured mast cells. | 1996 | Biochem. J. | pmid:9003387 |
| Wagenmann M et al. | Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2. | 1996 | Clin. Exp. Allergy | pmid:8732233 |
| Campbell A et al. | Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. | 1996 | Drugs | pmid:8983912 |
| Takahata R et al. | Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992498 |
| Ishimoto T et al. | Importance of the phospholipase D-initiated sequential pathway for arachidonic acid release and prostaglandin D2 generation by rat peritoneal mast cells. | 1996 | J. Biochem. | pmid:8902628 |
| Casimir DA et al. | Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. | 1996 | Differentiation | pmid:8765050 |
| Minami T et al. | Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819497 |
| Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
| Usatiuk PV et al. | [Content of prostaglandins E2 and F1alpha in small intestine epithelium in cattle as a function of age and pathology in non-infectious diarrhea]. | 1995 Mar-Apr | Ukr. Biokhim. Zh. | pmid:8592776 |
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Brouwer A et al. | Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin. | 1995 | Clin. Sci. | pmid:7720347 |
| Kawata R et al. | Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. | 1995 | J. Immunol. | pmid:7608559 |
| Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
| Pandey HP et al. | Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. | 1995 | Biochem. Mol. Biol. Int. | pmid:8595382 |
| Vesin MF et al. | Biosynthesis of prostaglandin D2 by motoneurons and dorsal horn microneurons: a biochemical and high resolution immunocytochemical study in chick spinal cord. | 1995 | Neuroscience | pmid:8596663 |
| Naffah-Mazzacoratti MG et al. | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. | 1995 | Neurochem. Int. | pmid:8574174 |
| Radziszewski W et al. | Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. | 1995 | Int. J. Cardiol. | pmid:8586470 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Cummings JJ | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep. | 1995 | J. Appl. Physiol. | pmid:8567564 |
| Wang DY et al. | Prostaglandin D2 measurement in nasal secretions is not a reliable marker for mast cell activation in atopic patients. | 1995 | Clin. Exp. Allergy | pmid:8821304 |
| Kawamoto K | [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]. | 1995 | Hum. Cell | pmid:8652450 |
| Yang KD et al. | A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. | 1995 | Acta Microbiol Immunol Hung | pmid:8689093 |
| Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
| Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |
| Hardy E et al. | Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. | 1995 | Thromb. Haemost. | pmid:8560425 |
| Osaka T and Hayaishi O | Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. | 1995 | Neurosci. Res. | pmid:8545074 |
| Daugschies A | Oesophagostomum dentatum: population dynamics and synthesis of prostanoids by histotropic stages cultured in vitro. | 1995 | Exp. Parasitol. | pmid:8542999 |
| Pilbeam CC et al. | Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. | 1995 | J. Bone Miner. Res. | pmid:7785462 |
| Koizumi T et al. | Identification of a cis-regulatory element for delta 12-prostaglandin J2-induced expression of the rat heme oxygenase gene. | 1995 | J. Biol. Chem. | pmid:7665598 |
| Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
| Hespeling U et al. | Feedback-inhibition of glucagon-stimulated glycogenolysis in hepatocyte/Kupffer cell cocultures by glucagon-elicited prostaglandin production in Kupffer cells. | 1995 | Hepatology | pmid:7590678 |
| Parker CW et al. | Modulation of IL-4 production in murine spleen cells by prostaglandins. | 1995 | Cell. Immunol. | pmid:7720090 |
| Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
| Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
| Rangachari PK et al. | Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? | 1995 | J. Pharmacol. Exp. Ther. | pmid:7473146 |
| Hayaishi O and Matsumura H | Prostaglandins and sleep. | 1995 | Adv. Neuroimmunol. | pmid:7496614 |
| Fernandes B and Crankshaw D | Functional characterization of the prostanoid DP receptor in human myometrium. | 1995 | Eur. J. Pharmacol. | pmid:7498323 |
| Kaye AD et al. | Analysis of thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1995 | Crit. Care Med. | pmid:7528116 |
| Peden DB and Dailey L | Modulation of mast cell functions by in vitro ozone exposure. | 1995 | Am. J. Physiol. | pmid:7611432 |
| Rabe KF et al. | Hydrogen peroxide contracts human airways in vitro: role of epithelium. | 1995 | Am. J. Physiol. | pmid:7573466 |
| Crankshaw DJ and Gaspar V | Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. | 1995 | J. Reprod. Fertil. | pmid:7535849 |
| Hartmann K et al. | Effect of CC chemokines on mediator release from human skin mast cells and basophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7580286 |
| De Vries GW et al. | An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. | 1995 | Br. J. Pharmacol. | pmid:7582550 |
| Negishi M et al. | Involvement of protein kinase in delta 12-prostaglandin J2-induced expression of rat heme oxygenase-1 gene. | 1995 | FEBS Lett. | pmid:7556684 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Ikai K et al. | Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630918 |
| Hu ZQ et al. | An essential role of prostaglandin E on mouse mast cell induction. | 1995 | J. Immunol. | pmid:7636261 |
| Boie Y et al. | Molecular cloning and characterization of the human prostanoid DP receptor. | 1995 | J. Biol. Chem. | pmid:7642548 |
| Murakami M et al. | IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. | 1995 | J. Immunol. | pmid:7594606 |
| van Haaster CM et al. | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases. | 1995 | Biochim. Biophys. Acta | pmid:7857988 |
| Reanmongkol W et al. | Inhibitory effect of alkaloids extracted from the stem bark of Hunteria zeylanica on 5-lipoxygenase activity in vitro. | 1995 | Biol. Pharm. Bull. | pmid:7550132 |
| Matsumoto K et al. | Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. | 1995 | J. Biochem. | pmid:7608139 |
| Serrero G and Lepak NM | Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626101 |
| Lee JH et al. | Induction of p53 and apoptosis by delta 12-PGJ2 in human hepatocarcinoma SK-HEP-1 cells. | 1995 | FEBS Lett. | pmid:7628635 |
| Guh JH et al. | Antiplatelet effect of gingerol isolated from Zingiber officinale. | 1995 | J. Pharm. Pharmacol. | pmid:7791032 |
| Lanas AI et al. | Non-steroidal anti-inflammatory drugs and prostaglandin effects on pepsinogen secretion by dispersed human peptic cells. | 1995 | Gut | pmid:7797113 |
| Grewe M et al. | Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. | 1995 | J. Invest. Dermatol. | pmid:7798637 |
| Horn EH et al. | Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia. | 1995 | Clin. Sci. | pmid:7545563 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. | 1995 | Eur Arch Otorhinolaryngol | pmid:7734974 |
| Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
| Downard CD et al. | Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. | 1995 | Clin. Pharmacol. Ther. | pmid:7712673 |