PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li P et al. | [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679661 |
| Benedetti F and Dogue S | Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. | 2015 | PLoS ONE | pmid:26536471 |
| Li XY et al. | 15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation. | 2015 | Genet. Mol. Res. | pmid:26535717 |
| Le Loupp AG et al. | Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system. | 2015 | BMC Gastroenterol | pmid:26338799 |
| Xu X et al. | Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. | 2015 | Cell. Physiol. Biochem. | pmid:26279448 |
| Xue L et al. | Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk. | 2015 | J. Allergy Clin. Immunol. | pmid:25441644 |
| Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
| Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
| Willenberg I et al. | Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). | 2015 | J Chromatogr A | pmid:25777050 |
| Savinainen JR et al. | Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). | 2014 | PLoS ONE | pmid:25290914 |
| Kuroyanagi G et al. | Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24813642 |
| Moon TC et al. | Expression of DP2 (CRTh2), a prostaglandin Dâ‚‚ receptor, in human mast cells. | 2014 | PLoS ONE | pmid:25268140 |
| Afrin LB | Mast cell activation syndrome as a significant comorbidity in sickle cell disease. | 2014 | Am. J. Med. Sci. | pmid:25171546 |
| Liu C et al. | 15d-PGJâ‚‚ decreases PGEâ‚‚ synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter. | 2014 | Biochem. Pharmacol. | pmid:25108236 |
| GarcÃa-Bueno B et al. | Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. | 2014 | Schizophr Bull | pmid:23486748 |
| Iwanaga K et al. | Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. | 2014 | Cancer Res. | pmid:24879565 |
| Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
| Shivers KY et al. | PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. | 2014 | Biochim. Biophys. Acta | pmid:24970746 |
| Kumar S et al. | Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. | 2014 | Int. Immunopharmacol. | pmid:24468678 |
| Moniot B et al. | Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. | 2014 | Development | pmid:25142465 |