PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Hyperemia D006940 25 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
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Alvarez-Maqueda M et al. 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. 2004 J. Biol. Chem. pmid:15024026
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Qin C et al. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. 2004 Mol. Cancer Ther. pmid:15026545
Hashimoto K et al. Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. 2004 Pancreas pmid:15028947
Liu JD et al. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. 2004 Life Sci. pmid:14998722
Hayaishi O et al. Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. 2004 Arch Ital Biol pmid:15493554
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Asami-Miyagishi R et al. Expression and function of PPARgamma in rat placental development. 2004 Biochem. Biophys. Res. Commun. pmid:14766236
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Higashihara H et al. Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. 2004 Redox Rep. pmid:15720834
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Lee KJ et al. Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. 2004 Exp. Mol. Med. pmid:15665586
Dahlén SE and Kumlin M Monitoring mast cell activation by prostaglandin D2 in vivo. 2004 Thorax pmid:15170020
Bochenek G et al. Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma. 2004 Thorax pmid:15170023
Cheron A et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. 2004 J. Immunol. pmid:15187150
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Fernández-Tome M et al. p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. 2004 Biochem. Biophys. Res. Commun. pmid:15249196
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Hofnagel O et al. Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15271788
Park KS et al. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. 2004 Exp. Cell Res. pmid:15212945
Takeshita K et al. CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. 2004 Int. Immunol. pmid:15173122
Cipollone F et al. Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15155382
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Chana RS et al. Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. 2004 Kidney Int. pmid:15149321
Garg TK and Chang JY 15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. 2004 BMC Pharmacol. pmid:15149553
Park EY et al. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. 2004 Cancer Res. pmid:15150131
Akbiyik F et al. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. 2004 Blood pmid:15130939
Han S et al. Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. 2004 Chest pmid:15136464
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Baolin L et al. Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. 2004 Planta Med. pmid:15095144
Zang C et al. Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. 2004 Leuk. Res. pmid:15109539
Jakob M et al. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. 2004 Rheumatology (Oxford) pmid:15113997
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Mouihate A et al. A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. 2004 J. Neurosci. pmid:14960602
Chatterjee PK et al. The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. 2004 Cardiovasc. Res. pmid:14962493