PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Hyperemia D006940 25 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Fu Y et al. Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. 2002 Atherosclerosis pmid:11755918
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Adachi H et al. Molecular characterization of human and rat organic anion transporter OATP-D. 2003 Am. J. Physiol. Renal Physiol. pmid:14631946
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Sugimoto H et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. 2003 J. Pharmacol. Exp. Ther. pmid:12649388
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Oliva JL et al. The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12684535
Paumi CM et al. Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. 2003 Biochemistry pmid:12731885
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Lu S et al. Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes. 2003 Adv. Exp. Med. Biol. pmid:12751756
Imaizumi T et al. 15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells. 2003 Int. Arch. Allergy Immunol. pmid:12759491
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Hinz B et al. 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. 2003 Biochem. Biophys. Res. Commun. pmid:12604364
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Abe M et al. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615657
Qin C et al. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. 2003 Cancer Res. pmid:12615709
Kajekar R et al. Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12618420
Wanichkul T et al. Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. 2003 Fertil. Steril. pmid:12620489
Monneret G et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. 2003 J. Pharmacol. Exp. Ther. pmid:12490611
Li L et al. RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. 2003 J. Biol. Chem. pmid:12493770
Winnett G et al. Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. 2003 Int. J. Cancer pmid:12494466
Kalla R et al. Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. 2003 Glia pmid:12465045
Hirano A et al. Arachidonic acid-induced channel- and carrier-type ion transport across planar bilayer lipid membranes. 2003 Anal Sci pmid:12608744