| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ureteral Obstruction | D014517 | 10 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nicoll-Griffith DA et al. | In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17095220 |
| Hortobágyi L et al. | Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. | 2007 | Brain Res. | pmid:17161389 |
| Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
| Sánchez-Gómez FJ et al. | Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. | 2007 | Arch. Biochem. Biophys. | pmid:17169324 |
| Huang ZL et al. | Prostaglandins and adenosine in the regulation of sleep and wakefulness. | 2007 | Curr Opin Pharmacol | pmid:17129762 |
| Kim HY and Kim HS | Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. | 2007 | Immunol. Cell Biol. | pmid:17130903 |
| Tanaka Y et al. | Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. | 2007 | Mol. Pharmacol. | pmid:17151289 |
| Rahman A et al. | Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. | 2007 | Eur. J. Pharmacol. | pmid:17112500 |
| Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
| Sugimoto M et al. | The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. | 2007 | Eur. J. Pharmacol. | pmid:17328887 |
| Suwaki N et al. | Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. | 2007 | Placenta | pmid:16753211 |
| Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
| Ruano D et al. | Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. | 2007 | Am. J. Med. Genet. B Neuropsychiatr. Genet. | pmid:17230501 |
| Haack M et al. | Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. | 2007 | Sleep | pmid:17910386 |
| Liu M et al. | Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. | 2007 | Neuroscience | pmid:17241746 |
| Tinfo N and Komar C | Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. | 2007 | Reproduction | pmid:17244745 |
| Lee JH et al. | 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. | 2007 | J. Korean Med. Sci. | pmid:17982241 |
| Payne SG et al. | The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. | 2007 | Blood | pmid:17008548 |
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| Porter DW et al. | PGJ2 inhibition of LPS-induced inflammatory mediator expression from rat alveolar macrophages. | 2007 | J. Toxicol. Environ. Health Part A | pmid:17966068 |
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| Sugimoto M et al. | Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17250998 |
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| Ito W et al. | Hepatocyte growth factor attenuates eotaxin and PGD2-induced chemotaxis of human eosinophils. | 2007 | Allergy | pmid:17362253 |
| Yang WZ et al. | [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. | 2007 | Zhonghua Gan Zang Bing Za Zhi | pmid:17362636 |
| Wilhelm D et al. | SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. | 2007 | J. Biol. Chem. | pmid:17277314 |
| Park JM et al. | Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. | 2007 | Cancer Res. | pmid:17283118 |
| Hammad H et al. | Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. | 2007 | J. Exp. Med. | pmid:17283205 |
| Kim HJ et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. | 2007 | Cancer Res. | pmid:17363578 |
| Yamada K et al. | Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. | 2007 | J Drug Target | pmid:17365274 |
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| Lin MS et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. | 2007 | J Dig Dis | pmid:17532820 |
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| Wang XS et al. | PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease. | 2007 | Allergy | pmid:17508965 |
| Monroy MA et al. | THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. | 2007 | Shock | pmid:17510607 |
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| Vunta H et al. | The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | 2007 | J. Biol. Chem. | pmid:17439952 |
| Taniguchi H et al. | Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. | 2007 | J. Neurosci. | pmid:17442814 |
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| Lim HJ et al. | 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17631927 |
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| Han H et al. | 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. | 2007 | Apoptosis | pmid:17786557 |
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| Kondoh K et al. | Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. | 2007 | Exp. Cell Res. | pmid:17706193 |
| Richard CL et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. | 2007 | Exp. Cell Res. | pmid:17707368 |
| Chen Y et al. | Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. | 2007 | J. Immunol. | pmid:17709490 |
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| Cossette C et al. | Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17041009 |
| Sandig H et al. | Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function. | 2007 | J. Leukoc. Biol. | pmid:17043246 |
| Kamagata C et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. | 2007 | Breast Cancer Res. Treat. | pmid:17028981 |
| Meyers CD et al. | Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. | 2007 | Atherosclerosis | pmid:16945375 |
| GarcÃa-Bueno B et al. | Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. | 2007 | Neuropsychopharmacology | pmid:17119541 |