| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fetal Alcohol Spectrum Disorders | D063647 | 6 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Hyperlipoproteinemia Type IV | D006953 | 6 associated lipids |
| Tauopathies | D024801 | 6 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Folliculitis | D005499 | 7 associated lipids |
| Multiple Sclerosis, Relapsing-Remitting | D020529 | 7 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Sleep Wake Disorders | D012893 | 7 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Paakinaho V et al. | Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation. | 2014 | Mol. Cell. Biol. | pmid:24980431 |
| Cichocka-Jarosz E et al. | Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children. | 2014 | Ann Agric Environ Med | pmid:24959779 |
| Mantel A et al. | Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. | 2014 | Exp. Dermatol. | pmid:24917395 |
| Tang J et al. | Aspirin treatment improved mesenchymal stem cell immunomodulatory properties via the 15d-PGJ2/PPARγ/TGF-β1 pathway. | 2014 | Stem Cells Dev. | pmid:24730450 |
| Chang JE et al. | Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. | 2014 | J. Allergy Clin. Immunol. | pmid:24210841 |
| Wang C et al. | A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. | 2014 | Nat. Methods | pmid:24292485 |
| Sarashina H et al. | Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation. | 2014 | J. Immunol. | pmid:24298012 |
| Olsen KC et al. | Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24175906 |
| Wong GW et al. | Ancient origin of mast cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25094046 |
| Li P et al. | [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679661 |
| Meng Y et al. | Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. | 2015 | Cell. Physiol. Biochem. | pmid:25591955 |
| Penas F et al. | Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. | 2015 | Biochim. Biophys. Acta | pmid:25557389 |
| Oishi Y et al. | The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. | 2015 | Brain Behav. Immun. | pmid:25532785 |
| Fukuoka T et al. | Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ. | 2015 | Int. J. Cancer | pmid:25516376 |
| Xue L et al. | Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk. | 2015 | J. Allergy Clin. Immunol. | pmid:25441644 |
| Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
| Säfholm J et al. | Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. | 2015 | J. Allergy Clin. Immunol. | pmid:25962903 |
| Wallert M et al. | α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. | 2015 | Mol Nutr Food Res | pmid:25943249 |
| Ott D et al. | Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia. | 2015 | Neurosci. Lett. | pmid:25912777 |
| Willenberg I et al. | Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). | 2015 | J Chromatogr A | pmid:25777050 |