| MeSH term | MeSH ID | Detail |
|---|---|---|
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Hyperlipoproteinemia Type IV | D006953 | 6 associated lipids |
| Tauopathies | D024801 | 6 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Sleep Wake Disorders | D012893 | 7 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
| Cao J et al. | In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium. | 2002 | Eur. J. Pharmacol. | pmid:12020689 |
| Sawano H et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. | 2002 | Kidney Int. | pmid:12028436 |
| Kondo M et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032289 |
| Krishnaswamy G et al. | Regulation of eosinophil-active cytokine production from human cord blood-derived mast cells. | 2002 | J. Interferon Cytokine Res. | pmid:12034046 |
| Lennon AM et al. | MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. | 2002 | J. Biol. Chem. | pmid:12052825 |
| Fujino T et al. | Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells. | 2002 | Br. J. Pharmacol. | pmid:12055131 |
| Ward C et al. | Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. | 2002 | J. Immunol. | pmid:12055237 |
| Zander T et al. | Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. | 2002 | J. Neurochem. | pmid:12065618 |
| Yagami T et al. | Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis. | 2002 | J. Neurochem. | pmid:12065654 |
| Wang YL et al. | Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival. | 2002 | J. Biol. Chem. | pmid:12082115 |
| Huang WC et al. | Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. | 2002 | Exp. Cell Res. | pmid:12083801 |
| Wayman NS et al. | Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. | 2002 | FASEB J. | pmid:12087064 |
| Lee B et al. | Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero. | 2002 | J. Neurosci. | pmid:12097519 |
| Fernández-Tomé Mdel C et al. | Phospholipase C inhibitors and prostaglandins differentially regulate phosphatidylcholine synthesis in rat renal papilla. Evidence of compartmental regulation of CTP:phosphocholine cytidylyltransferase and CDP-choline:1,2-diacylglycerol cholinephosphotransferase. | 2002 | Biochim. Biophys. Acta | pmid:12117562 |
| Menè P | Prostaglandin D2 : a Cinderella of vascular cell biology? | 2002 | J. Hypertens. | pmid:12131515 |
| Negoro H et al. | Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. | 2002 | J. Hypertens. | pmid:12131531 |
| Nencioni A et al. | Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. | 2002 | J. Immunol. | pmid:12133943 |
| Kudoh I et al. | [Prostanoids and acute lung injury]. | 2002 | Masui | pmid:12134647 |
| Yamamoto S et al. | Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha. | 2002 | Biochem. Pharmacol. | pmid:12147288 |