PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Dirofilariasis D004184 3 associated lipids
Down Syndrome D004314 18 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Erythema D004890 22 associated lipids
Fever D005334 35 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Li H and Pauza CD Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. 2009 PLoS ONE pmid:19888466
Morgenweck J et al. Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. 2010 Neuropharmacology pmid:19891980
Morii H and Watanabe Y Solubilization of prostaglandin D2 binding protein from porcine temporal cortex. 1991 Biochem. Biophys. Res. Commun. pmid:1989614
Liu JY et al. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. 2010 Biochem. Pharmacol. pmid:19896470
Toaldo C et al. PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. 2010 J. Cell. Mol. Med. pmid:19912441
Diers AR et al. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. 2010 Biochem. J. pmid:19916962
Mo C et al. PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. 2010 Cell. Signal. pmid:19922793
Dore-Duffy P et al. Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system. 1991 Neurology pmid:1992386
Kanda N et al. Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:19925780
Hori T et al. Prostaglandins antagonize fibroblast proliferation stimulated by tumor necrosis factor. 1991 Biochem. Biophys. Res. Commun. pmid:1993070
Wenzel SE et al. Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. 1991 J. Allergy Clin. Immunol. pmid:1993813
Zhang F et al. Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells. 2010 J. Neuroimmunol. pmid:19942298
Théoleyre S et al. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. 2010 Biochem. Biophys. Res. Commun. pmid:19951697
Shim J et al. The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. 2010 Int. J. Oncol. pmid:19956851
Buga GM et al. L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965777
Hovsepian E et al. 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. 2010 Shock pmid:19997048
Khanim FL et al. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. 2009 PLoS ONE pmid:19997560
Shimura C et al. Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. 2010 Am. J. Pathol. pmid:20008150
Yamaguchi S et al. Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146. 2010 J. Am. Chem. Soc. pmid:20014793
Prakash J et al. Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. 2009 Neoplasia pmid:20019843
Lin TH et al. Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. 2010 J. Cell. Physiol. pmid:20020468
Zorrilla S et al. Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to peroxisome proliferator-activated receptor gamma allows ligand identification and characterization. 2010 Anal. Biochem. pmid:20025845
Roy SJ et al. Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. 2010 Eur. J. Pharmacol. pmid:20035740
Lin TY and London CA Characterization and modulation of canine mast cell derived eicosanoids. 2010 Vet. Immunol. Immunopathol. pmid:20036014
Keenan CM and Rangachari PK Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon. 1991 Am. J. Physiol. pmid:2003610
Byrns MC et al. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. 2010 J. Steroid Biochem. Mol. Biol. pmid:20036328
Moraes LA et al. Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. 2010 J. Thromb. Haemost. pmid:20040043
Xiao Y et al. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. 2010 FEBS J. pmid:20050918
Watanabe K et al. 15-deoxy-delta 12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20056897
Bancos S et al. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. 2010 Cell. Immunol. pmid:20064636
Gallant MA et al. Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. 2010 J. Rheumatol. pmid:20080921
Zhang HX et al. Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). 2010 Exp. Neurol. pmid:20083106
Katura T et al. 15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state. 2010 Mol. Pharmacol. pmid:20086036
Poncin S et al. Oxidative stress: a required condition for thyroid cell proliferation. 2010 Am. J. Pathol. pmid:20093493
Satoh T et al. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. 2010 Acta Derm. Venereol. pmid:20107720
Veliça P et al. Prostaglandin D2 inhibits C2C12 myogenesis. 2010 Mol. Cell. Endocrinol. pmid:20109525
Blancou P and Anegon I Editorial: Heme oxygenase-1 and dendritic cells: what else? 2010 J. Leukoc. Biol. pmid:20123679
Schell C et al. 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. 2010 Endocrinology pmid:20133451
Fujitani Y et al. Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. 2010 FEBS J. pmid:20136655
Nørregaard R et al. Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20147610
Dionne S et al. PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. 2010 Anticancer Res. pmid:20150631
Zhu F et al. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. 2010 Cell Death Differ. pmid:20150912
Kim YI et al. Effects of 15-deoxy-∆¹²,¹⁴-prostaglandin J₂ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. 2011 Mol. Biol. Rep. pmid:20174873
Lou HQ et al. [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. 2010 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:20175238
Kim DH et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. 2010 Oncogene pmid:20208557
Cho HY et al. Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. 2010 Am. J. Respir. Crit. Care Med. pmid:20224069
Koharudin LM et al. Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20231490
Fukushima M [Prostaglandins and cell proliferation]. 1991 Tanpakushitsu Kakusan Koso pmid:2024021
Sasaki H et al. Human ovarian cancer cell lines resistant to cisplatin, doxorubicin, and L-phenylalanine mustard are sensitive to delta 7-prostaglandin A1 and delta 12-prostaglandin J2. 1991 Gynecol. Oncol. pmid:2026357
Mishra N et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. 2010 Biochem. Biophys. Res. Commun. pmid:20307494
Guo N et al. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. 2010 J. Biol. Chem. pmid:20308056
Kim SH et al. Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. 2010 Clin. Exp. Immunol. pmid:20345975
Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. 2010 Cancer Res. pmid:20354189
Lee JJ et al. The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. 2010 Arch. Pharm. Res. pmid:20361303
Koyama M et al. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. 2010 Clin. Cancer Res. pmid:20371690
Krall CM et al. Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20393159
Romanovsky AA and Garami A Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20410482
Subra C et al. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. 2010 J. Lipid Res. pmid:20424270
Hatanaka M et al. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. 2010 J. Pharmacol. Sci. pmid:20424389
Rodrigues WF et al. 15d-PGJ(2) modulates acute immune responses to Trypanosoma cruzi infection. 2010 Mem. Inst. Oswaldo Cruz pmid:20428671
Yokoyama Y et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. 2010 Ther Apher Dial pmid:20438519
Shiraya K et al. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. 2010 J. Biol. Chem. pmid:20448048
Hilliard M et al. The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. 2010 J. Biol. Chem. pmid:20457605
Bach-Ngohou K et al. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. 2010 J. Physiol. (Lond.) pmid:20478974
Masoodi M et al. Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. 2010 Exp. Dermatol. pmid:20482620
Poncin S et al. N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. 2010 Am. J. Pathol. pmid:20489149
Mutalithas K et al. CRTH2 expression on T cells in asthma. 2010 Clin. Exp. Immunol. pmid:20491797
Kaur S et al. Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate. 2010 J. Invest. Dermatol. pmid:20505747
Vesin MF et al. Preferential synthesis of prostaglandin D2 by neurons and prostaglandin E2 by fibroblasts and nonneuronal cells in chick dorsal root ganglia. 1991 J. Neurochem. pmid:2051162
Shah S et al. Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. 2010 Int. J. Clin. Pract. pmid:20518948
Genovese A et al. Human cardiac mast cells in anaphylaxis. 2010 Chem Immunol Allergy pmid:20519884
Diers AR et al. Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. 2010 Biochem. J. pmid:20536428
Vong L et al. A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20547854
Lehmann GM et al. Novel anti-adipogenic activity produced by human fibroblasts. 2010 Am. J. Physiol., Cell Physiol. pmid:20554910
Schuligoi R et al. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. 2010 Pharmacology pmid:20559016
Pedersen PJ et al. Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. 2010 Bioorg. Med. Chem. Lett. pmid:20591667
Norman P DP(2) receptor antagonists in development. 2010 Expert Opin Investig Drugs pmid:20615077
Reddy RC and Standiford TJ Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. 2010 Am. J. Respir. Crit. Care Med. pmid:20634499
Ahmad AS et al. Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. 2010 Age (Dordr) pmid:20640551
Bai YJ et al. A LC-MS-based method for quantification of biomarkers from serum of allergic rats. 2010 Molecules pmid:20657485
Orlichenko LS et al. Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20671197
Kar R et al. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. 2010 Biochem. Biophys. Res. Commun. pmid:20678484
Mor A et al. Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. 2011 Inflammation pmid:20706780
He R et al. The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. 2010 J. Allergy Clin. Immunol. pmid:20713302
Oh YC et al. Anti-allergic activity of a platycodon root ethanol extract. 2010 Int J Mol Sci pmid:20717534
van den Brule S et al. The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. 2010 J. Pharmacol. Exp. Ther. pmid:20719937
Fukushima M Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. 1990 Eicosanoids pmid:2073399
Inoue M et al. Interactions between the brain renin-angiotensin system and brain prostanoids in the control of vasopressin secretion. 1990 Exp Brain Res pmid:2073934
Syed MA et al. Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. 2010 Exp. Cell Res. pmid:20797396
Balzar S et al. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. 2011 Am. J. Respir. Crit. Care Med. pmid:20813890
Wang Y et al. Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. 2010 Chin. Med. J. pmid:20819509
Li H et al. Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. 2010 Biochemistry pmid:20853849
Maggiora M et al. Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells. 2010 Cell Biochem. Funct. pmid:20862655
Kanda N et al. The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes. 2011 Immunobiology pmid:20875690
Bräutigam K et al. Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. 2011 J. Cancer Res. Clin. Oncol. pmid:20878528
Alves C et al. Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. 2011 Br. J. Pharmacol. pmid:20883476
Hanks BC et al. Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs. 2010 Am. J. Vet. Res. pmid:20919899
Kim NJ et al. Concise and enantioselective total synthesis of 15-deoxy-Δ-(12,14)-prostaglandin J(2). 2010 J. Org. Chem. pmid:20929274
Pérez-Nievas BG et al. Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated. 2010 J Neuroinflammation pmid:20929574
Liu H et al. Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. 2011 Neurobiol. Dis. pmid:20933087