Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gazi L et al. | Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789622 |
Fowler CJ and Tiger G | Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | 2005 | Biochem. Pharmacol. | pmid:15794945 |
Dore-Duffy P et al. | The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series. | 2005 | Microvasc. Res. | pmid:15797264 |
Liu J et al. | Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15838654 |
Ji JD et al. | Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. | 2005 | Rheumatology (Oxford) | pmid:15840591 |
Mitchell MD et al. | Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15840748 |
Usui S et al. | Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15745794 |
Storer PD et al. | Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. | 2005 | J. Neuroimmunol. | pmid:15748950 |
Spik I et al. | Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. | 2005 | J. Immunol. | pmid:15749909 |
Mochizuki M et al. | Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15750045 |
Moulin D et al. | Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. | 2005 | Arthritis Rheum. | pmid:15751073 |
Viñals M et al. | Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. | 2005 | Cardiovasc. Res. | pmid:15769457 |
Yuan Z et al. | Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. | 2005 | Heart | pmid:15774612 |
Inoue K et al. | Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. | 2005 | Arzneimittelforschung | pmid:15819389 |
Sanchez-Rodriguez J et al. | The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. | 2005 | Biochem. J. | pmid:15819613 |
Kim YS et al. | Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. | 2005 | Free Radic. Biol. Med. | pmid:15589375 |
Almishri W et al. | Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15590767 |
Hwang J et al. | Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590897 |
López-Parra M et al. | The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. | 2005 | J. Hepatol. | pmid:15629510 |
Scher JU and Pillinger MH | 15d-PGJ2: the anti-inflammatory prostaglandin? | 2005 | Clin. Immunol. | pmid:15639643 |
Wu CC et al. | 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. | 2005 | Eur. J. Pharmacol. | pmid:16313903 |
Son JK et al. | Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2005 | Biol. Pharm. Bull. | pmid:16327145 |
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Benyó Z et al. | GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. | 2005 | J. Clin. Invest. | pmid:16322797 |
Coyle AT et al. | 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. | 2005 | FEBS J. | pmid:16156795 |
Chen WC et al. | Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. | 2005 | Chin. Med. J. | pmid:16157051 |
Uehara Y | [Prostaglandin D2]. | 2005 | Nippon Rinsho | pmid:16149440 |
Zamuner SR et al. | Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. | 2005 | Am. J. Pathol. | pmid:16251413 |
Negoro H et al. | Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. | 2005 | Life Sci. | pmid:16154157 |
O'Flaherty JT et al. | 5-Oxo-ETE analogs and the proliferation of cancer cells. | 2005 | Biochim. Biophys. Acta | pmid:16154383 |
Jawerbaum A et al. | Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. | 2005 | Reproduction | pmid:16264098 |
Mandal AK et al. | Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation. | 2005 | J. Immunol. | pmid:16272277 |
Xue L et al. | Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. | 2005 | J. Immunol. | pmid:16272307 |
Gayarre J et al. | Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione. | 2005 | FEBS Lett. | pmid:16223487 |
Hatoum OA et al. | Novel mechanism of vasodilation in inflammatory bowel disease. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141408 |
Noguchi J et al. | Strain difference of murine bone marrow-derived mast cell functions. | 2005 | J. Leukoc. Biol. | pmid:16126842 |
Marone G et al. | Role of human mast cells and basophils in bronchial asthma. | 2005 | Adv. Immunol. | pmid:16227089 |
Jin YR et al. | An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. | 2005 | Basic Clin. Pharmacol. Toxicol. | pmid:16128910 |
Fujishima H et al. | Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis. | 2005 | Cornea | pmid:16227827 |
Nie M et al. | Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. | 2005 | J. Biol. Chem. | pmid:15531761 |
Kobayashi Y et al. | Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. | 2005 | J. Immunol. | pmid:16237065 |
Na HK et al. | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. | 2005 | FEBS Lett. | pmid:16253239 |
Shiraishi Y et al. | Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15528449 |
Chen HH et al. | Effects of trichloroethylene and perchloroethylene on muscle contractile responses and epithelial prostaglandin release and acetylcholinesterase activity in swine trachea. | 2005 | Toxicol. Sci. | pmid:15496499 |
Piva R et al. | 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. | 2005 | Blood | pmid:15498850 |
Monneret G et al. | Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15388786 |
Muñoz U et al. | The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. | 2005 | Exp. Neurol. | pmid:16061222 |
Chen ZY and Tseng CC | 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. | 2005 | Mol. Pharmacol. | pmid:16077033 |
Chevalier E et al. | Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. | 2005 | J. Immunol. | pmid:16081770 |
Polikandriotis JA et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16020752 |
Kim J et al. | Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. | 2005 | Cancer Res. | pmid:16024620 |
Choi YH et al. | New anti-inflammatory formulation containing Synurus deltoides extract. | 2005 | Arch. Pharm. Res. | pmid:16114500 |
Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
Hata AN et al. | Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. | 2005 | J. Biol. Chem. | pmid:16030019 |
Motilva V et al. | COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. | 2005 | Int. Immunopharmacol. | pmid:15652766 |
MartÃnez B et al. | The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. | 2005 | J. Lipid Res. | pmid:15654126 |
Liang X et al. | Prostaglandin D2 mediates neuronal protection via the DP1 receptor. | 2005 | J. Neurochem. | pmid:15659218 |
Shen ZN et al. | Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15694358 |
Shiraki T et al. | Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. | 2005 | J. Biol. Chem. | pmid:15695504 |
Bulló M et al. | Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15713689 |
GarcÃa-Bueno B et al. | The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. | 2005 | Psychopharmacology (Berl.) | pmid:15719215 |
Storer PD et al. | Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. | 2005 | J. Neurosci. Res. | pmid:15723383 |
Migita H and Morser J | 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15662020 |
O'Reilly KM et al. | Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15665045 |
Jerde TJ et al. | Celecoxib inhibits ureteral contractility and prostanoid release. | 2005 | Urology | pmid:15667901 |
Figarella K et al. | Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. | 2005 | Cell Death Differ. | pmid:15678148 |
Tanaka T et al. | Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. | 2005 | Eur. J. Pharmacol. | pmid:15680279 |
Genovese T et al. | Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. | 2005 | Eur. Respir. J. | pmid:15684285 |
Marzocco S et al. | The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. | 2005 | Intensive Care Med | pmid:15868139 |
Yoshida M et al. | Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts. | 2005 | J. Rheumatol. | pmid:15868610 |
Li X et al. | Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. | 2005 | J. Rheumatol. | pmid:15868626 |
De Oliveira C et al. | Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. | 2005 | J. Lab. Clin. Med. | pmid:15871306 |
Planagumà A et al. | The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. | 2005 | FASEB J. | pmid:15876570 |
Kim HY et al. | Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. | 2005 | Immunol. Cell Biol. | pmid:15877607 |
Blanco M et al. | Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. | 2005 | Stroke | pmid:15879329 |
Hashimoto Y et al. | Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. | 2005 | J. Pharmacol. Sci. | pmid:15879676 |
Pataki I et al. | In vivo effects of isatin on rat platelet eicosanoids. | 2005 | Platelets | pmid:15763895 |
MartÃn AR et al. | The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. | 2005 | Inflamm. Res. | pmid:15883736 |
Chen YC et al. | Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. | 2005 | Biochim. Biophys. Acta | pmid:15843042 |
Ackerman WE et al. | Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. | 2005 | Biol. Reprod. | pmid:15843495 |
Drew PD et al. | Hormone regulation of microglial cell activation: relevance to multiple sclerosis. | 2005 | Brain Res. Brain Res. Rev. | pmid:15850670 |
Gallant MA et al. | Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. | 2005 | J. Bone Miner. Res. | pmid:15765187 |
Kämpfer H et al. | Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. | 2005 | Diabetes | pmid:15855344 |
Saito H | [Mast cells]. | 2005 | Nippon Rinsho | pmid:15861652 |
Costello DA et al. | Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. | 2005 | Neuropharmacology | pmid:15993441 |
Patel KM et al. | Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). | 2005 | Cell. Signal. | pmid:15993751 |
Zurich MG et al. | Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. | 2005 | Neuroscience | pmid:15994020 |
Chacón P et al. | Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. | 2005 | Eur. J. Immunol. | pmid:15997464 |
Honma Y et al. | Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. | 2005 | Eur. J. Pharmacol. | pmid:16000196 |
Kim HJ et al. | 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. | 2005 | Exp. Mol. Med. | pmid:16000871 |
Ibabe A et al. | Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. | 2005 | Toxicol In Vitro | pmid:15964169 |
Pande V and Ramos MJ | Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16006125 |
Eggler AL et al. | Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16006525 |
Matsuzaki Y et al. | 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. | 2005 | Int. J. Oncol. | pmid:16010433 |
Kaplan JM et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. | 2005 | Shock | pmid:15988322 |
Tomita H et al. | Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. | 2005 | Cardiovasc. Res. | pmid:15949477 |
Atkins KB et al. | Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15345487 |
Maurin AC et al. | Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. | 2005 | Calcif. Tissue Int. | pmid:15868283 |
Burgess HA et al. | PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15734787 |
Inoue K et al. | Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743408 |