Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
Tsao CJ et al. | In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. | 1986 | Leuk. Res. | pmid:3012210 |
Halenda SP et al. | Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. | 1986 | FEBS Lett. | pmid:3015684 |
Hickok NJ et al. | Characterization of prostaglandin endoperoxide synthase from a human cell line. | 1986 | Biochim. Biophys. Acta | pmid:3087430 |
Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
Hamid-Bloomfield S and Whittle BJ | Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. | 1986 | Br. J. Pharmacol. | pmid:3017497 |
Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
Suzuki H et al. | [Inhibition of growth of human endometrial adenocarcinoma cells in vitro treated with prostaglandin F2 alpha, E2, D2 and J2]. | 1986 | Nihon Naibunpi Gakkai Zasshi | pmid:3465609 |
Ashby B | Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes. | 1986 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2432105 |
Koro O et al. | Release of prostaglandin D2 and histamine in a case of localized heat urticaria, and effect of treatments. | 1986 | Br. J. Dermatol. | pmid:2432916 |
Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
Keeting PE et al. | Rat lens prostaglandin biosynthesis during galactose-induced cataractogenesis. | 1986 | Exp. Eye Res. | pmid:3028846 |
Horiguchi S et al. | Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. | 1986 | Eur. J. Pharmacol. | pmid:3458588 |
Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
Peters SP et al. | The pharmacologic control of mediator release from human basophils and mast cells. | 1986 | Respiration | pmid:3494282 |
Bhuyan BK et al. | Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. | 1986 | Cancer Res. | pmid:3456266 |
Brooks DP et al. | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. | 1986 | Endocrinology | pmid:3456303 |
Suzuki F et al. | Transport of prostaglandin D2 into brain. | 1986 | Brain Res. | pmid:3465420 |
Ikai K et al. | Ear swelling in response to UVB irradiation. | 1986 | Arch. Dermatol. Res. | pmid:3466577 |
Rees MC and Kelly RW | Prostaglandin D2 release by endometrium and myometrium. | 1986 | Br J Obstet Gynaecol | pmid:3466645 |
Hardy CC et al. | Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man. | 1986 | Br. J. Pharmacol. | pmid:3467804 |
Makhoul RG and Gewertz BL | Renal prostaglandins. | 1986 | J. Surg. Res. | pmid:3511324 |
Inoué S | Multifactorial humoral regulation of sleep. | 1986 | Clin Neuropharmacol | pmid:3471328 |
Fuller RW et al. | Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. | 1986 | Am. Rev. Respir. Dis. | pmid:3511806 |
Blockmans D et al. | Heparin-induced thrombocytopenia platelet aggregation studies in the presence of heparin fractions or semi-synthetic analogues of various molecular weights and anticoagulant activities. | 1986 | Thromb. Haemost. | pmid:3518134 |
Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
Watanabe Y et al. | Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. | 1986 | Brain Res. | pmid:2873871 |
Huddleston KW et al. | Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs. | 1986 | Dev Pharmacol Ther | pmid:3530674 |
Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
Strobl-Jäger E et al. | Influence of type IIa, IIb and IV-hyperlipoproteinemia on platelet prostaglandin sensitivity, plasma thromboxane B2 and platelet half-life. | 1986 | Prostaglandins Leukot Med | pmid:3540998 |
Haxhiu MA et al. | [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. | 1986 Jan-Mar | Plucne Bolesti | pmid:3466189 |
Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959094 |
Wendelborn DF et al. | Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959099 |
Pugliese G et al. | 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959104 |
Robinson C et al. | Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960146 |
Roberts LJ | Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960165 |
Prakash C et al. | Synthesis of putative prostaglandin D2 metabolites. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960191 |
Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
Omini C et al. | Prostaglandin D2 and the cholinergic system in guinea pig airways. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823557 |
Viganò T et al. | Adenosine and eicosanoid release from immunologically challenged human lung fragments. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823581 |
Richelsen B | Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. | 1987 | Biochem. Pharmacol. | pmid:2825710 |
Greaves MW et al. | [New pharmacologic developments in physical urticaria--therapeutic consequences]. | 1987 | Z. Hautkr. | pmid:3472418 |
Goto H | [Quantitative determination of prostaglandin D2 in the rat gastric mucosa by high performance liquid chromatography]. | 1987 | Nihon Shokakibyo Gakkai Zasshi | pmid:3473244 |
Kariya T et al. | Platelet abnormality with no response to PGD2 in a patient with metastatic pancreas carcinoma and myeloproliferative disorder. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3473883 |
Holgate ST | Contribution of inflammatory mediators to the immediate asthmatic reaction. | 1987 | Am. Rev. Respir. Dis. | pmid:3473955 |