| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Erythema | D004890 | 22 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cough | D003371 | 19 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moulin D et al. | Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. | 2005 | Arthritis Rheum. | pmid:15751073 |
| Viñals M et al. | Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. | 2005 | Cardiovasc. Res. | pmid:15769457 |
| Yuan Z et al. | Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. | 2005 | Heart | pmid:15774612 |
| Inoue K et al. | Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. | 2005 | Arzneimittelforschung | pmid:15819389 |
| Sanchez-Rodriguez J et al. | The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. | 2005 | Biochem. J. | pmid:15819613 |
| Kim YS et al. | Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. | 2005 | Free Radic. Biol. Med. | pmid:15589375 |
| Almishri W et al. | Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15590767 |
| Hwang J et al. | Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590897 |
| López-Parra M et al. | The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. | 2005 | J. Hepatol. | pmid:15629510 |
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| Hata AN et al. | Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. | 2005 | Mol. Pharmacol. | pmid:15563582 |
| Armer RE et al. | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. | 2005 | J. Med. Chem. | pmid:16190744 |
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| Chevalier E et al. | Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. | 2005 | J. Immunol. | pmid:16081770 |
| Polikandriotis JA et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16020752 |
| Kim J et al. | Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. | 2005 | Cancer Res. | pmid:16024620 |
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| Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
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| Nakae K et al. | Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. | 2005 | Neurosci. Lett. | pmid:16039053 |
| O'Reilly KM et al. | Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15665045 |
| Jerde TJ et al. | Celecoxib inhibits ureteral contractility and prostanoid release. | 2005 | Urology | pmid:15667901 |
| Figarella K et al. | Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. | 2005 | Cell Death Differ. | pmid:15678148 |
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| Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
| Malki S et al. | Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. | 2005 | EMBO J. | pmid:15889150 |
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| Drew PD et al. | Hormone regulation of microglial cell activation: relevance to multiple sclerosis. | 2005 | Brain Res. Brain Res. Rev. | pmid:15850670 |
| Kämpfer H et al. | Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. | 2005 | Diabetes | pmid:15855344 |
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| Pereira MP et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16034372 |
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| Gayarre J et al. | Addition of electrophilic lipids to actin alters filament structure. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16979589 |
| Zhang YJ et al. | Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). | 2006 | Am. J. Nephrol. | pmid:16864989 |
| Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
| Lee E et al. | Anti-asthmatic activity of an ethanol extract from Saururus chinensis. | 2006 | Biol. Pharm. Bull. | pmid:16462020 |
| Raetz CR et al. | Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. | 2006 | J. Lipid Res. | pmid:16479018 |
| Nakahata Y et al. | The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. | 2006 | BMC Mol. Biol. | pmid:16483373 |
| Damrongsri D et al. | Effects of Delta12-prostaglandin J2 on bone regeneration and growth factor expression in rats. | 2006 | Clin Oral Implants Res | pmid:16441784 |
| Mesquita-Santos FP et al. | Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. | 2006 | J. Immunol. | pmid:16424158 |
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| Kang HY et al. | Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. | 2006 | Arch. Dermatol. Res. | pmid:16474974 |