| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuan ZY et al. | [Peroxisome proliferation-activated receptor-gamma ligands ameliorate autoimmune myocarditis associated with inhibition of T cell immunity]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:14703419 |
| Zhang M et al. | [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:12921638 |
| Wang WM et al. | [Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16681946 |
| Li SJ et al. | [Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17425848 |
| Cao LQ et al. | [15-deoxy-Delta(12,14)-prostaglandin J(2) induces anoikis of hepatocellular carcinoma cells: an in vitro experiment]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:18261336 |
| Wan CJ et al. | [PPARgamma agonists against respiratory syncytial virus infection in vitro study]. | 2011 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:22734242 |
| Yang WZ et al. | [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. | 2007 | Zhonghua Gan Zang Bing Za Zhi | pmid:17362636 |
| Li SJ et al. | [Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy]. | 2007 | Zhonghua Fu Chan Ke Za Zhi | pmid:17983488 |
| Liu P et al. | [Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8257841 |
| Ye P et al. | [The role of peroxisome proliferator-activated receptor gamma in proliferation of cardiac non myocytes]. | 2006 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162229 |
| Li WY et al. | Effect of 15-Deoxy-â–³(12,14)-prostaglandin J2 on Expression of Macrophage Migration Inhibitory Factor in Mouse Monocyte/macrophage Cell Line J774A.1. | 2016 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:27544994 |
| Yue TL and Mai K | [Effects of protein malnutrition on the metabolism of arachidonic acid in the rat stomach and spleen]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3142210 |
| Chi Y et al. | [Effect of 15-deoxy-Δ(12), 14-prostaglandin J2 on the cytokines in the culture supernatant of bone marrow mesenchymal stem cells]. | 2013 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24370048 |
| Lou HQ et al. | [CRTH2 antagonist ameliorates airway inflammation in rats with asthma]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175238 |
| Greaves MW et al. | [New pharmacologic developments in physical urticaria--therapeutic consequences]. | 1987 | Z. Hautkr. | pmid:3472418 |
| Chung HS et al. | Heat contact urticaria--a case report. | 1996 | Yonsei Med. J. | pmid:8826790 |
| Liu TY et al. | [Advances in the study of histaminergic systems and sleep-wake regulation]. | 2011 | Yao Xue Xue Bao | pmid:21626776 |
| Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
| Ma XM et al. | Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. | 2009 | World J. Gastroenterol. | pmid:19701967 |
| Dong YW et al. | Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. | 2009 | World J. Gastroenterol. | pmid:19152448 |
| Chen YX et al. | 15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. | 2003 | World J. Gastroenterol. | pmid:14562367 |
| Jović N et al. | Do prostaglandins E2, F2 alpha and D2 have a role in the development of idiopathic trigeminal neuralgia? | 1996 May-Jun | Vojnosanit Pregl | pmid:9174396 |
| Urade Y and Hayaishi O | Prostaglandin D synthase: structure and function. | 2000 | Vitam. Horm. | pmid:10668396 |
| Arnold R and König W | Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | 2006 | Virology | pmid:16616290 |
| Arnold R and König W | Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. | 2006 | Virology | pmid:16330064 |
| Boisvert M et al. | PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells. | 2008 | Virology | pmid:18755491 |
| Yoshitake R et al. | Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines. | 2017 | Vet. J. | pmid:28283079 |
| Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
| Cerrato S et al. | Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells. | 2010 | Vet. Immunol. Immunopathol. | pmid:19625089 |
| Liu Y et al. | Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. | 2008 | Vet. Immunol. Immunopathol. | pmid:18394717 |
| BrazÃs P et al. | Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 release. | 2006 | Vet. Dermatol. | pmid:16674731 |
| Gueck T et al. | Influence of vitamin E on mast cell mediator release. | 2002 | Vet. Dermatol. | pmid:12464062 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
| Lee JJ et al. | Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. | 2006 | Vascul. Pharmacol. | pmid:16916624 |
| Yuan J et al. | Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. | 2005 | Urology | pmid:15780399 |
| Park JM | Role of prostaglandins in bladder smooth muscle cell gene expression. | 2001 | Urology | pmid:11378068 |
| Jerde TJ et al. | Celecoxib inhibits ureteral contractility and prostanoid release. | 2005 | Urology | pmid:15667901 |
| Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
| Quarello E and Trabbia A | High-definition flow combined with spatiotemporal image correlation in the diagnosis of fetal coarctation of the aorta. | 2009 | Ultrasound Obstet Gynecol | pmid:19194864 |
| Usatiuk PV et al. | [Content of prostaglandins E2 and F1alpha in small intestine epithelium in cattle as a function of age and pathology in non-infectious diarrhea]. | 1995 Mar-Apr | Ukr. Biokhim. Zh. | pmid:8592776 |
| Harris SG et al. | Prostaglandins as modulators of immunity. | 2002 | Trends Immunol. | pmid:11864843 |
| Peters SP et al. | The role of prostaglandin D2 in IgE-mediated reactions in man. | 1982 | Trans. Assoc. Am. Physicians | pmid:6963831 |
| Murray JJ et al. | Prostaglandin D2 is released during acute allergic bronchospasm in man. | 1985 | Trans. Assoc. Am. Physicians | pmid:3870298 |
| McRea JC et al. | Prostaglandin releasing polymers - stability and efficacy. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7036503 |
| Kimura LF et al. | Mast cells and histamine play an important role in edema and leukocyte recruitment induced by Potamotrygon motoro stingray venom in mice. | 2015 | Toxicon | pmid:26100666 |
| Moreira V et al. | Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. | 2007 | Toxicon | pmid:17241651 |
| Moreira V et al. | Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases. | 2008 | Toxicon | pmid:18619987 |
| Galvão Nascimento N et al. | Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. | 2010 Feb-Mar | Toxicon | pmid:19703484 |
| Koh SH et al. | 15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant? | 2005 | Toxicology | pmid:16191461 |
| Lee DR et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. | 2009 | Toxicology | pmid:19167456 |