| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Horak F et al. | Effect of continuous allergen challenge on clinical symptoms and mediator release in dust-mite-allergic patients. | 1998 | Allergy | pmid:9491231 |
| Ricote M et al. | The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. | 1998 | Nature | pmid:9422508 |
| Jiang C et al. | PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. | 1998 | Nature | pmid:9422509 |
| Tan W et al. | Modulation of nicotinic AChR channels by prostaglandin E2 in chick sympathetic ganglion neurons. | 1998 | J. Neurophysiol. | pmid:9463448 |
| Nagoshi H et al. | Prostaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells. | 1998 | Circ. Res. | pmid:9468191 |
| Nagy L et al. | Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. | 1998 | Cell | pmid:9568715 |
| Yang VW et al. | Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. | 1998 | Cancer Res. | pmid:9563494 |
| Mooney JJ et al. | Signal transduction by platelet adenylate cyclase: alterations in depressed patients may reflect impairment in the coordinated integration of cellular signals (coincidence detection). | 1998 | Biol. Psychiatry | pmid:9564442 |
| Souza SC et al. | BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones. | 1998 | Diabetes | pmid:9568706 |
| Tontonoz P et al. | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. | 1998 | Cell | pmid:9568716 |
| Austin S et al. | Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells. | 1998 | Cell Growth Differ. | pmid:9543393 |
| Fukushima S et al. | [Pharmaceutical and pharmacological development of antitumor prostaglandins]. | 1998 | Nippon Rinsho | pmid:9549353 |
| Akarsu ES et al. | Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2. | 1998 | Epilepsy Res. | pmid:9551845 |
| Hayaishi O | [Prostaglandins and sleep]. | 1998 | Nippon Rinsho | pmid:9503823 |
| Urade Y | [Gene engineering studies on sleep]. | 1998 | Nippon Rinsho | pmid:9503856 |
| Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
| Giardiello FM et al. | Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. | 1998 | Dig. Dis. Sci. | pmid:9512123 |
| Chan CL and Lau HY | Effects of prostanoid receptor agonists on immunologically-activated rat peritoneal mast cells. | 1998 | Inflamm. Res. | pmid:9561397 |
| Lau HY and Stenton GR | Effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2 specific inhibitors on mediator release from rat peritoneal mast cells. | 1998 | Inflamm. Res. | pmid:9561398 |
| Sutarmo Setiadji V et al. | Actions of prostaglandin E2 on rat supraoptic neurones. | 1998 | J. Neuroendocrinol. | pmid:9870750 |
| Terao A et al. | Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats. | 1998 | Neuroreport | pmid:9875706 |
| Gambero A and Gomes JC | Pharmacological antagonism of Anchietia salutaris extracts on the contraction induced by prostaglandin D2 and U46619 in guinea-pig lung parenchymal strips. | 1998 | J. Pharm. Pharmacol. | pmid:9877316 |
| Crider JY et al. | Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758211 |
| Gao T et al. | Arachidonic acid metabolism to prostaglandin E2, D2, F2alpha, and I2 in the plerocercoid of Spirometra erinaceieuropaei. | 1998 | J. Parasitol. | pmid:9920298 |
| Huszár E et al. | Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs. | 1998 | J. Allergy Clin. Immunol. | pmid:9802380 |
| Ohtani-Fujita N et al. | p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792828 |
| Tada K et al. | Induction of cyclooxygenase-2 by secretory phospholipases A2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions. | 1998 | J. Immunol. | pmid:9794438 |
| Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
| Madhu C et al. | Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. | 1998 | J Ocul Pharmacol Ther | pmid:9811228 |
| Szczeklik A et al. | Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9769277 |
| Fiebich BL et al. | Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer's disease. | 1998 | J. Neural Transm. Suppl. | pmid:9850935 |
| Christman BW | Lipid mediator dysregulation in primary pulmonary hypertension. | 1998 | Chest | pmid:9741570 |
| Takahashi S et al. | Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA. | 1998 | Biochem. J. | pmid:9742210 |
| Csala M et al. | Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. | 1998 | Scand. J. Immunol. | pmid:9743211 |
| Kilunga Kubata B et al. | Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. | 1998 | J. Exp. Med. | pmid:9743538 |
| Torii SI et al. | Thiazolidinedione induces the adipose differentiation of fibroblast-like cells resident within bovine skeletal muscle. | 1998 | Cell Biol. Int. | pmid:10328850 |
| Marx N et al. | Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. | 1998 | Circ. Res. | pmid:9831704 |
| Dorta-Contreras AJ et al. | [Beta trace protein in the cerebrospinal fluid and serum in meningoencephalitis]. | 1998 | Rev Neurol | pmid:9585948 |
| Demoly P et al. | [Nose and sinus: anatomo-pathologic relations]. | 1998 | Allerg Immunol (Paris) | pmid:9631692 |
| Ikai K et al. | Induction of apoptosis, p53 and heme oxygenase-1 by cytotoxic prostaglandin delta12-PGJ2 in transformed endothelial cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654403 |
| Rosenbaum SE and Greenberg AS | The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. | 1998 | Mol. Endocrinol. | pmid:9717841 |
| Yoshida T et al. | Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer. | 1998 | Surg. Today | pmid:9697269 |
| Terao A et al. | Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. | 1998 | J. Neurosci. | pmid:9698346 |
| Scammell T et al. | Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9636223 |
| Moon TC et al. | Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells. | 1998 | Cell. Immunol. | pmid:9636692 |
| Iijima K et al. | Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642130 |
| Fujitani Y et al. | [Sleep-promoting substances]. | 1998 | Nihon Ronen Igakkai Zasshi | pmid:10064966 |
| O'Sullivan S et al. | Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine. | 1998 | Thorax | pmid:10195076 |
| Ward PE et al. | Niacin skin flush in schizophrenia: a preliminary report. | 1998 | Schizophr. Res. | pmid:9516668 |
| Longo WE et al. | Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990676 |
| Löhrke B et al. | Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells. | 1998 | J. Endocrinol. | pmid:9834460 |
| Haberl C et al. | Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. | 1998 | Mediators Inflamm. | pmid:9836493 |
| Longo WE et al. | The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation. | 1998 | Mediators Inflamm. | pmid:9836494 |
| Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
| Shichijo M et al. | The effects of anti-asthma drugs on mediator release from cultured human mast cells. | 1998 | Clin. Exp. Allergy | pmid:9824389 |
| Ahn SG et al. | The role of c-Myc and heat shock protein 70 in human hepatocarcinoma Hep3B cells during apoptosis induced by prostaglandin A2/Delta12-prostaglandin J2. | 1998 | Biochim. Biophys. Acta | pmid:9824682 |
| Graf BA et al. | Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. | 1999 | Eur. J. Immunol. | pmid:10556836 |
| Petersen LJ and Skov PS | The effect of salmeterol and salbutamol on mediator release and skin responses in immediate and late phase allergic cutaneous reactions. | 1999 | Inflamm. Res. | pmid:10563469 |
| Wise H | Characterization of chimeric prostacyclin/prostaglandin D(2) receptors. | 1999 | Eur. J. Pharmacol. | pmid:10611468 |
| Lin Q et al. | Ligand selectivity of the peroxisome proliferator-activated receptor alpha. | 1999 | Biochemistry | pmid:9890897 |
| Vaidya S et al. | 15-Deoxy-Delta12,1412,14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation. | 1999 | J. Immunol. | pmid:10570310 |
| Chou TC and Li CY | Inhibitory mechanisms of dantrolene on platelet aggregation. | 1999 | Thromb. Res. | pmid:10593433 |
| Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
| Heneka MT et al. | Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. | 1999 | J. Neuroimmunol. | pmid:10695726 |
| Herschman HR | Function and regulation of prostaglandin synthase 2. | 1999 | Adv. Exp. Med. Biol. | pmid:10667302 |
| Murakami M et al. | Regulation of prostaglandin, leukotriene, and platelet-activating factor metabolism in mast cells. | 1999 | Adv. Exp. Med. Biol. | pmid:10667307 |
| Satoh H et al. | Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9920814 |
| Conti C et al. | Antiviral effect of hyperthermic treatment in rhinovirus infection. | 1999 | Antimicrob. Agents Chemother. | pmid:10103186 |
| Shichijo M et al. | Role of cyclic 3',5'-adenosine monophosphate in the regulation of chemical mediator release and cytokine production from cultured human mast cells. | 1999 | J. Allergy Clin. Immunol. | pmid:10329844 |
| Eguchi N et al. | Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9892701 |
| Herbertsson H et al. | The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit. | 1999 | Arch. Biochem. Biophys. | pmid:10375396 |
| Satoh T et al. | Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10222233 |
| Goetze S et al. | PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10226869 |
| Kitamura Y et al. | Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. | 1999 | Neurosci. Lett. | pmid:10203248 |
| Rouaud C et al. | The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation. | 1999 | Br. J. Pharmacol. | pmid:10051118 |
| Makker HK et al. | Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge. | 1999 | Clin. Exp. Allergy | pmid:10051729 |
| Marx N et al. | PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073956 |
| Walch L et al. | Prostanoid receptors involved in the relaxation of human pulmonary vessels. | 1999 | Br. J. Pharmacol. | pmid:10193765 |
| Norel X et al. | Prostanoid receptors involved in the relaxation of human bronchial preparations. | 1999 | Br. J. Pharmacol. | pmid:10193766 |
| Sawada H et al. | Regulation of type V phospholipase A2 expression and function by proinflammatory stimuli. | 1999 | Eur. J. Biochem. | pmid:10469147 |
| Keelan JA et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471366 |
| Pucci ML et al. | Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. | 1999 | Am. J. Physiol. | pmid:10484490 |
| Santos J et al. | Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. | 1999 | Gut | pmid:10486364 |
| Anderson LE et al. | Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum. | 1999 | J. Reprod. Fertil. | pmid:10505064 |
| Clay CE et al. | Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. | 1999 | Carcinogenesis | pmid:10506103 |
| Valmaseda A et al. | Opposite regulation of PPAR-alpha and -gamma gene expression by both their ligands and retinoic acid in brown adipocytes. | 1999 | Mol. Cell. Endocrinol. | pmid:10509805 |
| Reddy ST et al. | Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10548515 |
| Stillman BA et al. | Importance of the extracellular domain for prostaglandin EP(2) receptor function. | 1999 | Mol. Pharmacol. | pmid:10462542 |
| Wright DH et al. | A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. | 1999 | Eur. J. Pharmacol. | pmid:10448933 |
| Su CG et al. | A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. | 1999 | J. Clin. Invest. | pmid:10449430 |
| Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
| Hayaishi O | Prostaglandin D2 and sleep--a molecular genetic approach. | 1999 | J Sleep Res | pmid:10389108 |
| Salińska E et al. | Role of Ca2+ release from ryanodine stores in generation of NMDA-induced Ca2+ signal in rabbit hippocampus. | 1999 | Ross Fiziol Zh Im I M Sechenova | pmid:10389178 |
| Pelton PD et al. | PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425206 |
| Chinery R et al. | Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. | 1999 | Cancer Res. | pmid:10364000 |
| Crider JY et al. | Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists. | 1999 | Br. J. Pharmacol. | pmid:10369474 |
| Chan CL and Lau HY | Prostanoid DP receptor activation inhibits anti-IgE induced histamine release from rat peritoneal mast cells. | 1999 | Inflamm. Res. | pmid:10350148 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep regulation. | 1999 | Biochim. Biophys. Acta | pmid:9989291 |
| Sakamoto H et al. | Effect of intracellular glutathione on the production of prostaglandin D2 in RBL-2H3 cells oxidized by tert-butyl hydroperoxide. | 1999 | J. Biochem. | pmid:9880802 |
| Obata T et al. | Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. | 1999 | Clin. Exp. Allergy | pmid:10457118 |