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The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. |
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[Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy]. |
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PGJ2 inhibition of LPS-induced inflammatory mediator expression from rat alveolar macrophages. |
2007 |
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Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. |
2007 |
Biochemistry |
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A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. |
2007 |
Blood |
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Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. |
2007 |
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Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. |
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J Dig Dis |
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Role of prostaglandins on mechanical scratching-induced cutaneous barrier disruption in mice. |
2007 |
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Functional characteristics of the porcine colonic epithelium following transportation stress and Salmonella infection. |
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PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease. |
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Allergy |
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THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. |
2007 |
Shock |
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Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. |
2007 |
Shock |
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The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. |
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Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. |
2007 |
Prostaglandins Other Lipid Mediat. |
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The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). |
2007 |
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[The role of lipid mediators in allergic diseases]. |
2007 |
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Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. |
2007 |
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Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics. |
2007 |
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PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. |
2007 |
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PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. |
2007 |
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Involvement of PPARgamma in human trophoblast invasion. |
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Placenta |
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Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
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ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. |
2007 |
J. Korean Med. Sci. |
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[15-deoxy-Delta(12,14)-prostaglandin J(2) induces anoikis of hepatocellular carcinoma cells: an in vitro experiment]. |
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A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. |
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Am. J. Physiol. Lung Cell Mol. Physiol. |
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A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. |
2007 |
Immunology |
pmid:17437532
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Meyers CD et al. |
Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. |
2007 |
Atherosclerosis |
pmid:16945375
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Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. |
2007 |
Neuropsychopharmacology |
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[Anaphylaxis and anaphylactic shock]. |
2007 Mar-Apr |
Rev Alerg Mex |
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(-)-epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts. |
2007 Oct-Nov |
Prostaglandins Leukot. Essent. Fatty Acids |
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Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. |
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Formation of eicosanoids, E2/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain. |
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J. Lipid Res. |
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AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. |
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Mol. Cell. Endocrinol. |
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7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells. |
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J. Steroid Biochem. Mol. Biol. |
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NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. |
2008 |
Neurotoxicology |
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A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils. |
2008 |
Eur. J. Clin. Invest. |
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Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. |
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Mol. Cancer Ther. |
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Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. |
2008 |
Mol Pain |
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Different effects of spinally applied prostaglandin D2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation. |
2008 |
Neuroscience |
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Opposite effects of PU.1 on mast cell stimulation. |
2008 |
Biochem. Biophys. Res. Commun. |
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Prostaglandin D2 receptors DP and CRTH2 in the pathogenesis of asthma. |
2008 |
Curr. Mol. Med. |
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Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major. |
2008 |
Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |
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15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase. |
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15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. |
2008 |
J. Cell. Physiol. |
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Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. |
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J. Hepatol. |
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Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). |
2008 |
J. Pharmacol. Exp. Ther. |
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Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. |
2008 |
Biochem. Biophys. Res. Commun. |
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Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. |
2008 |
Shock |
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Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. |
2008 |
J. Leukoc. Biol. |
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Regulation of TLR2 expression by prostaglandins in brain glia. |
2008 |
J. Immunol. |
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Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. |
2008 |
Biochim. Biophys. Acta |
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15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. |
2008 |
Antioxid. Redox Signal. |
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PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells. |
2008 |
J. Neurochem. |
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Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. |
2008 |
Hepatology |
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PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells. |
2008 |
Virology |
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15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. |
2008 |
Blood |
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Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. |
2008 |
J. Immunol. |
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Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway. |
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J. Immunol. |
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Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation. |
2008 |
Neuroreport |
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Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. |
2008 |
Gene |
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Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. |
2008 |
Endocrinology |
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Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. |
2008 |
J. Neurochem. |
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Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. |
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Effects of 15-deoxy-Delta12, 14 prostaglandin J2 and ciglitazone on human cancer cell cycle progression and death: the role of PPARgamma. |
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Eur. J. Pharmacol. |
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Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species. |
2008 |
J Sex Med |
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Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts. |
2008 |
Clin. Exp. Pharmacol. Physiol. |
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15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses. |
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Chem. Res. Toxicol. |
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SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. |
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Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. |
2008 |
J. Allergy Clin. Immunol. |
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15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. |
2008 |
Carcinogenesis |
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CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine. |
2008 |
Pharmacology |
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Novel biphasic role for lymphocytes revealed during resolving inflammation. |
2008 |
Blood |
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Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells. |
2008 |
Biochem. Biophys. Res. Commun. |
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Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. |
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Biochem. J. |
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Doing what I like. |
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Annu. Rev. Immunol. |
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Inhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides. |
2008 |
Int. Arch. Allergy Immunol. |
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Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture. |
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Neurochem. Res. |
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Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility. |
2008 |
Eur. J. Pharmacol. |
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Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. |
2008 |
Atherosclerosis |
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CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. |
2008 |
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Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. |
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Vet. Immunol. Immunopathol. |
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Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. |
2008 |
Prostaglandins Other Lipid Mediat. |
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Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. |
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Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. |
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J Pain |
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Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells. |
2008 |
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The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. |
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Arch. Pharm. Res. |
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A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. |
2008 |
Nephrol. Dial. Transplant. |
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Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. |
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