| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Black PN et al. | Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 on bronchial responsiveness to histamine in normal subjects. | 1989 | Thorax | pmid:2548300 |
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Kerr JS et al. | Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558648 |
| Kawabe Y et al. | Genesis and recovery of ethanol-induced gastric lesions in rats: possible involvement of prostaglandin D2. | 1989 | Am. J. Gastroenterol. | pmid:2916522 |
| Sakai T et al. | Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. | 1989 | Cancer Res. | pmid:2917351 |
| Phillips GD and Holgate ST | Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma. | 1989 | J. Appl. Physiol. | pmid:2917934 |
| Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
| Naclerio RM et al. | The effect of cetirizine on early allergic response. | 1989 | Laryngoscope | pmid:2566879 |
| Ohuchi K et al. | Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. | 1989 | Biochim. Biophys. Acta | pmid:2469475 |
| Wolfe LS et al. | Synthesis and functions of cyclooxygenase and lipoxygenase products in brain: new findings and an appraisal. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2568735 |
| Wolfe LS and Pellerin L | Arachidonic acid metabolites in the rat and human brain. New findings on the metabolism of prostaglandin D2 and lipoxygenase products. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2570544 |
| Bhattacharya SK et al. | Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats. | 1989 | J. Pharm. Pharmacol. | pmid:2571705 |
| Zehr BB et al. | Use of segmental airway lavage to obtain relevant mediators from the lungs of asthmatic and control subjects. | 1989 | Chest | pmid:2539958 |
| Benyon RC | The human skin mast cell. | 1989 | Clin. Exp. Allergy | pmid:2667702 |
| Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
| Salari H and Chan-Yeung M | Interleukin-1 potentiates antigen-mediated arachidonic acid metabolite formation in mast cells. | 1989 | Clin. Exp. Allergy | pmid:2513105 |
| Chakraborti S et al. | Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium. | 1989 | Am. J. Physiol. | pmid:2514605 |
| Yoshimura S et al. | Prostaglandin D2 receptor of mastocytoma P-815 cells--possible regulation by phosphorylation and dephosphorylation. | 1989 | Biochim. Biophys. Acta | pmid:2497784 |
| Ikai K et al. | Prostaglandin D2, a mediator in both immediate and delayed-type immune reactions in the skin. | 1989 | Dermatologica | pmid:2506083 |
| Hatanaka M et al. | Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. | 1989 | J. Neurochem. | pmid:2507741 |
| Urade Y et al. | The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. | 1989 | J. Immunol. | pmid:2509561 |
| Ito S et al. | Prostaglandin D2: a biochemical perspective. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2510183 |
| Virgolini I et al. | Effects of taprostene, a chemically stable prostacyclin analogue, in patients with ischaemic peripheral vascular disease: a placebo controlled double-blind trial. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2514430 |
| Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
| Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
| Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
| Sugama K et al. | Stimulation of cAMP formation by prostaglandin D2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. | 1989 | Biochim. Biophys. Acta | pmid:2538150 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. | 1989 | Prostaglandins | pmid:2475889 |
| Gray PR et al. | The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. | 1989 | Am. Rev. Respir. Dis. | pmid:2502051 |
| Froissart P et al. | Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187. | 1989 | Biochim. Biophys. Acta | pmid:2496761 |
| Keenan CM and Rangachari PK | Eicosanoid interactions in the canine proximal colon. | 1989 | Am. J. Physiol. | pmid:2539737 |
| Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
| Wolfe LS et al. | Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. | 1989 | J. Neurochem. | pmid:2723663 |
| Deckers IA et al. | Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. | 1989 | Eur. J. Pharmacol. | pmid:2806380 |
| Kuiper J et al. | Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells. | 1989 | Biochem. J. | pmid:2818563 |
| Rodriguez y Baena R et al. | Effects of nicardipine on the ex vivo release of eicosanoids after experimental subarachnoid hemorrhage. | 1989 | J. Neurosurg. | pmid:2585083 |
| Marone G | Control mechanisms of mediator release in human basophils and mast cells. | 1988 Nov-Dec | Immunol. Invest. | pmid:2465995 |
| Hayaishi O | Sleep-wake regulation by prostaglandins D2 and E2. | 1988 | J. Biol. Chem. | pmid:3049580 |
| Iwai M et al. | Potential role for prostaglandin F2 alpha, D2, E2 and thromboxane A2 in mediating the metabolic and hemodynamic actions of sympathetic nerves in perfused rat liver. | 1988 | Eur. J. Biochem. | pmid:3165341 |
| Tran-Thi TA et al. | Net prostaglandin release by perfused rat liver after stimulation with phorbol 12-myristate 13-acetate. | 1988 | J. Hepatol. | pmid:3166024 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
| Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
| Lebel B et al. | Spontaneous and non-specific release of histamine and PGD2 by bronchoalveolar lavage cells from asthmatic and normal subjects: effect of nedocromil sodium. | 1988 | Clin. Allergy | pmid:2468432 |
| Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
| Chock SP and Schmauder-Chock EA | Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3190706 |
| Rodriguez y Baena R et al. | A study on cisternal CSF levels of arachidonic acid metabolites after aneurysmal subarachnoid hemorrhage. | 1988 | J. Neurol. Sci. | pmid:3132538 |
| Ormerod AD et al. | Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation. | 1988 | J. Allergy Clin. Immunol. | pmid:2459177 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |