PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
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Xiao Y et al. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. 2010 FEBS J. pmid:20050918
van den Brule S et al. The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. 2010 J. Pharmacol. Exp. Ther. pmid:20719937
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Buga GM et al. L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965777
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Li H et al. Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. 2010 Biochemistry pmid:20853849
Bancos S et al. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. 2010 Cell. Immunol. pmid:20064636
Pacienza N et al. 15-deoxy-Delta(12,14)-PGJ(2) induces cell cycle arrest and apoptosis of haematopoietic progenitors. 2010 Br. J. Haematol. pmid:19764987
Lee CM et al. Prostaglandin expression profile in hypoxic osteoblastic cells. 2010 J. Bone Miner. Metab. pmid:19471853
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Koyama M et al. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. 2010 Clin. Cancer Res. pmid:20371690
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Cho HY et al. Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. 2010 Am. J. Respir. Crit. Care Med. pmid:20224069
Krall CM et al. Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20393159
Lee JJ et al. The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. 2010 Arch. Pharm. Res. pmid:20361303
Lin TH et al. Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. 2010 J. Cell. Physiol. pmid:20020468
Hovsepian E et al. 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. 2010 Shock pmid:19997048
Théoleyre S et al. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. 2010 Biochem. Biophys. Res. Commun. pmid:19951697
Shim J et al. The peroxisome proliferator-activated receptor gamma ligands, pioglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), have antineoplastic effects against hepatitis B virus-associated hepatocellular carcinoma cells. 2010 Int. J. Oncol. pmid:19956851
Bach-Ngohou K et al. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. 2010 J. Physiol. (Lond.) pmid:20478974
Masoodi M et al. Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. 2010 Exp. Dermatol. pmid:20482620
Hilliard M et al. The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. 2010 J. Biol. Chem. pmid:20457605
Yokoyama Y et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells. 2010 Ther Apher Dial pmid:20438519
Romanovsky AA and Garami A Prostaglandin riddles in energy metabolism: E is for excess, D is for depletion. Focus on "Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2". 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20410482
Shiraya K et al. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. 2010 J. Biol. Chem. pmid:20448048
Mishra N et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. 2010 Biochem. Biophys. Res. Commun. pmid:20307494
Guo N et al. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. 2010 J. Biol. Chem. pmid:20308056
Poncin S et al. N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. 2010 Am. J. Pathol. pmid:20489149
Kolaczkowska E et al. Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. 2009 Nov-Dec Arch. Immunol. Ther. Exp. (Warsz.) pmid:19885646
Moreira V et al. Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19155166
Kase K et al. Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. 2009 Int. J. Mol. Med. pmid:19212651
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Lee DR et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. 2009 Toxicology pmid:19167456
Quarello E and Trabbia A High-definition flow combined with spatiotemporal image correlation in the diagnosis of fetal coarctation of the aorta. 2009 Ultrasound Obstet Gynecol pmid:19194864
Ishii T et al. Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. 2009 Blood pmid:19196660
Passeron T et al. Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. 2009 J. Clin. Invest. pmid:19273910
Yuan ZB et al. Temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. 2009 Inflamm. Res. pmid:19184357
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Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
O'Brien JJ et al. 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. 2009 J. Thromb. Haemost. pmid:18983509
Kalantari P et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. 2009 FASEB J. pmid:19299483
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Moriai M et al. Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. 2009 Int. J. Oncol. pmid:19360348
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Shin SW et al. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. 2009 Clin. Cancer Res. pmid:19690198
Wendeburg L et al. Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. 2009 J Neuroinflammation pmid:19751497
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Johansson S et al. CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. 2009 Inflammation pmid:19132521
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Di Francesco L et al. Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. 2009 Circ. Res. pmid:19122175
Wang WM et al. PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. 2009 Acta Pharmacol. Sin. pmid:19098936
Waku T et al. Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. 2009 FEBS Lett. pmid:19101554
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301
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Cocca C et al. 15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. 2009 Biochem. Pharmacol. pmid:19576185
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Comabella M et al. Plasma levels of 15d-PGJ are not altered in multiple sclerosis. 2009 Eur. J. Neurol. pmid:19538219
Qin HD et al. Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. 2009 J. Cell. Physiol. pmid:19562688
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Bai G et al. Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. 2009 Peptides pmid:19539681
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Pena-dos-Santos DR et al. Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. 2009 Neuroscience pmid:19647045
Lauring B et al. Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. 2009 J Clin Pharmacol pmid:19833861
Hironaka A et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. 2009 Biochem. Biophys. Res. Commun. pmid:19799872
Ohinata K et al. Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. 2009 Prostaglandins Other Lipid Mediat. pmid:19800413
Tagen M et al. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. 2009 J. Immunol. pmid:19846869
Davies NJ et al. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. 2009 Cancer Res. pmid:19487289