| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sleep Wake Disorders | D012893 | 7 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Thyroid Diseases | D013959 | 8 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Chondrosarcoma | D002813 | 9 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Retinopathy of Prematurity | D012178 | 9 associated lipids |
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ma J et al. | Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload. | 2016 | Sci Rep | pmid:27089935 |
| Zhou J et al. | Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats. | 2016 | J. Cell. Mol. Med. | pmid:27061967 |
| Wang M et al. | The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. | 2016 | Biol. Pharm. Bull. | pmid:27040628 |
| Nagira Y et al. | Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs. | 2016 | J. Pharmacol. Exp. Ther. | pmid:26945085 |
| Bambouskova M et al. | New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. | 2016 | Mol. Cell. Biol. | pmid:26929198 |
| Sykes DA et al. | Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy. | 2016 | Mol. Pharmacol. | pmid:26916831 |
| Shin JS et al. | Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry. | 2016 | J Chromatogr A | pmid:27524299 |
| Martinez-Cengotitabengoa M et al. | BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. | 2016 | Schizophr Bull | pmid:26130821 |
| Hölscher C et al. | Defects in Peroxisomal 6-Phosphogluconate Dehydrogenase Isoform PGD2 Prevent Gametophytic Interaction in Arabidopsis thaliana. | 2016 | Plant Physiol. | pmid:26941195 |
| Kugathas S et al. | Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX-2 Active Site, and Implications for Endocrine Disruption. | 2016 | Environ. Health Perspect. | pmid:26359731 |
| Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
| Le Loupp AG et al. | [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. | 2015 Jun-Jul | Med Sci (Paris) | pmid:26152165 |
| Huang L et al. | 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. | 2015 | Biomed Res Int | pmid:26844229 |
| Wojno ED et al. | The prostaglandin Dâ‚‚ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. | 2015 | Mucosal Immunol | pmid:25850654 |
| Virtue S et al. | Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. | 2015 | Int J Obes (Lond) | pmid:25801691 |
| Nittner-Marszalska M et al. | 9α,11β-PGF2, a Prostaglandin D2 Metabolite, as a Marker of Mast Cell Activation in Bee Venom-Allergic Patients. | 2015 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:25763689 |
| Maier NK et al. | The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. | 2015 | J. Immunol. | pmid:25681332 |
| Wall SB et al. | Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. | 2015 | Redox Biol | pmid:25677088 |
| Hosoi T et al. | Possible involvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development of leptin resistance. | 2015 | J. Neurochem. | pmid:25662180 |
| Ishii T | Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation. | 2015 | Free Radic. Biol. Med. | pmid:25968070 |