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Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. |
2009 |
Leukemia |
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Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. |
2009 |
Blood |
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Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. |
2009 |
J. Clin. Invest. |
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2009 |
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Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. |
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Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. |
2009 |
Shock |
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Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. |
2009 |
Immunology |
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Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2). |
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Eur. J. Pharmacol. |
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. |
2009 |
Endocrinology |
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2009 |
Dig. Dis. Sci. |
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2009 |
Clin. Exp. Allergy |
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15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. |
2009 |
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Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. |
2009 |
J Neuroinflammation |
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2009 |
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15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells. |
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15-Deoxy-delta 12, 14,-prostaglandin J2 suppresses nuclear factor-kappaB-mediated apoptosis of Helicobacter pylori-infected gastric epithelial cells. |
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Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. |
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2009 |
Clin. Exp. Allergy |
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A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. |
2009 |
Int. Immunol. |
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Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. |
2009 |
Int. Immunol. |
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Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. |
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Chem. Biol. Interact. |
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A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. |
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Oncogene |
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Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. |
2009 |
Reproduction |
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A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. |
2009 |
Clin. Exp. Allergy |
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2009 |
Pulm Pharmacol Ther |
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Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. |
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Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. |
2009 |
Clin Nutr |
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Peptides |
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Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. |
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J Neuroinflammation |
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Neuroscience |
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Prostaglandins Leukot. Essent. Fatty Acids |
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Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. |
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Prostaglandins Other Lipid Mediat. |
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The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. |
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The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. |
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Neoplasia |
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Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. |
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PLoS ONE |
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A quercetin containing supplement reduces niacin-induced flush in humans. |
2008 Jul-Sep |
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2008 Jul-Aug |
Drug News Perspect. |
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Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. |
2008 Jul-Aug |
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2008 Jul-Aug |
Prostaglandins Leukot. Essent. Fatty Acids |
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Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. |
2008 |
Endocrinology |
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Contribution of prostaglandin D2 via prostanoid DP receptor to nasal hyperresponsiveness in guinea pigs repeatedly exposed to antigen. |
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AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. |
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Mol. Cell. Endocrinol. |
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Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. |
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Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. |
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Cancer Lett. |
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Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. |
2008 |
Blood |
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Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. |
2008 |
Am. J. Nephrol. |
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Comparison of short term in vitro cultured human mast cells from different progenitors - Peripheral blood-derived progenitors generate highly mature and functional mast cells. |
2008 |
J. Immunol. Methods |
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15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. |
2008 |
Pharmacol. Res. |
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Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. |
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Mol. Cancer Ther. |
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15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. |
2008 |
Mol. Cancer Ther. |
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Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma. |
2008 |
Allergol Int |
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Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. |
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Cancer Detect. Prev. |
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Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. |
2008 |
Allergol Int |
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TGF-beta1 attenuates mediator release and de novo Kit expression by human skin mast cells through a Smad-dependent pathway. |
2008 |
J. Immunol. |
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Regulation of TLR2 expression by prostaglandins in brain glia. |
2008 |
J. Immunol. |
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An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. |
2008 |
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Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. |
2008 |
Mol. Cancer Ther. |
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Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. |
2008 |
Prostaglandins Other Lipid Mediat. |
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Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases. |
2008 |
Toxicon |
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Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. |
2008 |
Mol. Hum. Reprod. |
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Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production. |
2008 |
Int. Arch. Allergy Immunol. |
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Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. |
2008 |
Nutr J |
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Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins. |
2008 |
J. Cell. Sci. |
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The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. |
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J. Immunol. |
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PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells. |
2008 |
Br. J. Cancer |
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The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. |
2008 |
J. Immunol. |
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Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor. |
2008 |
Biochem. Biophys. Res. Commun. |
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Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. |
2008 |
Gene |
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On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. |
2008 |
Cell. Mol. Life Sci. |
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Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. |
2008 |
J. Allergy Clin. Immunol. |
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Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice. |
2008 |
Hepatology |
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The flavonoid luteolin inhibits niacin-induced flush. |
2008 |
Br. J. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells. |
2008 |
J. Dairy Res. |
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Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma. |
2008 |
J. Immunol. |
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Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats. |
2008 |
Peptides |
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Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture. |
2008 |
Neurochem. Res. |
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