| MeSH term | MeSH ID | Detail |
|---|---|---|
| Wounds, Stab | D014951 | 3 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Urticaria Pigmentosa | D014582 | 4 associated lipids |
| Urticaria | D014581 | 13 associated lipids |
| Ureteral Obstruction | D014517 | 10 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Trigeminal Neuralgia | D014277 | 1 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hayaishi O et al. | Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960208 |
| Narumiya S and Fukushima M | Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960214 |
| Ono K et al. | Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960215 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Saito R et al. | The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. | 1987 | Pharmacol. Biochem. Behav. | pmid:2883669 |
| Chiabrando C et al. | Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. | 1987 | Cancer Res. | pmid:3100032 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. | 1987 | Pharm. Res. | pmid:2977646 |
| Santoro MG et al. | PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. | 1987 | J. Gen. Virol. | pmid:3033130 |
| Kozuka T et al. | Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. | 1987 | J. Invest. Dermatol. | pmid:2433354 |
| Abdel-Malek ZA et al. | In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. | 1987 | Cancer Res. | pmid:2438034 |
| Dieter P et al. | Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. | 1987 | Eur. J. Biochem. | pmid:2826152 |
| Amano N | [Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats]. | 1987 | Masui | pmid:3480360 |
| Brunelli G et al. | PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig. | 1987 | J Auton Pharmacol | pmid:3480891 |
| Weinreich D and Wonderlin WF | Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. | 1987 | J. Physiol. (Lond.) | pmid:3481834 |
| Nakamura M et al. | In vivo effects of prostaglandins on human retinoblastoma cells in nude mice. | 1987 | Jpn. J. Ophthalmol. | pmid:3482290 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
| Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
| Casteleijn E et al. | Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. | 1988 | Biochem. J. | pmid:3162673 |
| Ishioka C et al. | Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. | 1988 | Cancer Res. | pmid:3162825 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
| Soifer SJ et al. | Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. | 1988 | J. Pediatr. | pmid:3162978 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Lebel B et al. | Spontaneous and non-specific release of histamine and PGD2 by bronchoalveolar lavage cells from asthmatic and normal subjects: effect of nedocromil sodium. | 1988 | Clin. Allergy | pmid:2468432 |
| Sonoki H et al. | [Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2]. | 1988 | Nippon Yakurigaku Zasshi | pmid:3163668 |
| Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
| Moore PK et al. | Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro. | 1988 | Eur. J. Pharmacol. | pmid:3053211 |
| Hirata Y et al. | Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. | 1988 | J. Biol. Chem. | pmid:3053696 |
| Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
| Hoult JR et al. | Organ selective conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and its subsequent metabolism in rat, rabbit and guinea pig. | 1988 | Biochem. Pharmacol. | pmid:3178873 |
| Nakamura O et al. | [Antineoplastic effect of prostaglandins on human glioma in athymic nude mice]. | 1988 | No To Shinkei | pmid:3179087 |
| Rao PS et al. | The effect of prostaglandin D2 on angiotensin converting enzyme. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2845437 |
| Ormerod AD et al. | Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation. | 1988 | J. Allergy Clin. Immunol. | pmid:2459177 |
| Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
| Michel L et al. | Prostaglandin D2 generation in mouse bone marrow-derived mast cells exposed to dexamethasone is associated with endogenous peroxidase activity. | 1988 | Lab. Invest. | pmid:2460694 |
| Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
| Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
| Church MM et al. | The mediator and cellular basis of the allergic response. | 1988 | Allergy | pmid:2462372 |
| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
| Ohno K et al. | Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361448 |
| Dieter P et al. | Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. | 1988 | Eur. J. Biochem. | pmid:2846298 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
| Fukushima M | [Prostaglandin J2--anti-tumor activity and mechanism of action]. | 1988 | Nippon Rinsho | pmid:3043050 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Yokotani K et al. | Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3422095 |
| Robinson C et al. | The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | 1988 | Biochim. Biophys. Acta | pmid:3196723 |
| Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |