| MeSH term | MeSH ID | Detail |
|---|---|---|
| Wounds, Stab | D014951 | 3 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Urticaria Pigmentosa | D014582 | 4 associated lipids |
| Urticaria | D014581 | 13 associated lipids |
| Ureteral Obstruction | D014517 | 10 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Trigeminal Neuralgia | D014277 | 1 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
| Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
| Barnea A et al. | Evidence that a short-lived effect of copper leads to amplification of prostaglandin E2 stimulation of the release of gonadotropin-releasing hormone from median eminence explants. | 1986 | Endocrinology | pmid:3525128 |
| Nordlund JJ et al. | Prostaglandin E2 and D2 but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of the DBA/2 mouse. | 1986 | J. Invest. Dermatol. | pmid:3528310 |
| Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Tsao CJ et al. | In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. | 1986 | Leuk. Res. | pmid:3012210 |
| Halenda SP et al. | Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. | 1986 | FEBS Lett. | pmid:3015684 |
| Hickok NJ et al. | Characterization of prostaglandin endoperoxide synthase from a human cell line. | 1986 | Biochim. Biophys. Acta | pmid:3087430 |
| Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
| Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
| Hamid-Bloomfield S and Whittle BJ | Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. | 1986 | Br. J. Pharmacol. | pmid:3017497 |
| Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Ohno K et al. | Metabolic dehydration of prostaglandin E2 and cellular uptake of the dehydration product: correlation with prostaglandin E2-induced growth inhibition. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3464277 |
| Peters SP et al. | Mediator release from human lung under conditions of reduced oxygen tension. | 1986 | J. Pharmacol. Exp. Ther. | pmid:2425080 |
| Wells E et al. | Characterization of primate bronchoalveolar mast cells. I. IgE-dependent release of histamine, leukotrienes, and prostaglandins. | 1986 | J. Immunol. | pmid:2431048 |
| MacDermot J | Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo. | 1986 | Biochem. Pharmacol. | pmid:2427086 |
| Heavey DJ et al. | Prostaglandin D2 and histamine release in cold urticaria. | 1986 | J. Allergy Clin. Immunol. | pmid:2428856 |
| Suzuki H et al. | [Inhibition of growth of human endometrial adenocarcinoma cells in vitro treated with prostaglandin F2 alpha, E2, D2 and J2]. | 1986 | Nihon Naibunpi Gakkai Zasshi | pmid:3465609 |
| Watanabe K | [PGF synthetase]. | 1986 | Seikagaku | pmid:3084680 |
| Blomgren H et al. | Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. | 1986 | Radiother Oncol | pmid:3466235 |
| Kriseman T et al. | Analysis of airway responses to A23187 in the cat. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3095538 |
| Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
| Eling TE et al. | Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. | 1986 | J. Biol. Chem. | pmid:3007487 |
| Narumiya S and Fukushima M | Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3772804 |
| Kato T et al. | Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. | 1986 | Cancer Res. | pmid:3708585 |
| Keeting PE et al. | Rat lens prostaglandin biosynthesis during galactose-induced cataractogenesis. | 1986 | Exp. Eye Res. | pmid:3028846 |
| Horiguchi S et al. | Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. | 1986 | Eur. J. Pharmacol. | pmid:3458588 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Peters SP et al. | The pharmacologic control of mediator release from human basophils and mast cells. | 1986 | Respiration | pmid:3494282 |
| Bhuyan BK et al. | Cell cycle effects of prostaglandins A1, A2, and D2 in human and murine melanoma cells in culture. | 1986 | Cancer Res. | pmid:3456266 |
| Brooks DP et al. | Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat. | 1986 | Endocrinology | pmid:3456303 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Ruzicka T et al. | Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. | 1986 | J. Invest. Dermatol. | pmid:3018086 |
| Kuno S et al. | Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3458226 |
| Ikai K et al. | Ear swelling in response to UVB irradiation. | 1986 | Arch. Dermatol. Res. | pmid:3466577 |
| Rees MC and Kelly RW | Prostaglandin D2 release by endometrium and myometrium. | 1986 | Br J Obstet Gynaecol | pmid:3466645 |
| Hardy CC et al. | Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man. | 1986 | Br. J. Pharmacol. | pmid:3467804 |
| Makhoul RG and Gewertz BL | Renal prostaglandins. | 1986 | J. Surg. Res. | pmid:3511324 |
| Inoué S | Multifactorial humoral regulation of sleep. | 1986 | Clin Neuropharmacol | pmid:3471328 |
| Bhuyan BK et al. | Cytotoxicity of combinations of prostaglandin D2 (PGD2) and antitumor drugs for B16 melanoma cells in culture. | 1986 | Invest New Drugs | pmid:3473056 |
| Dutta-Roy AK et al. | Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. | 1986 | Science | pmid:3001935 |
| Tokumoto H et al. | Specificity of prostaglandin D2 binding to synaptic membrane fraction of rat brain. | 1986 | Brain Res. | pmid:2867812 |
| Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
| Watanabe Y et al. | Modulation by prostaglandin D2 of mitral cell responses to odor stimulation in rabbit olfactory bulb. | 1986 | Brain Res. | pmid:2873871 |
| Huddleston KW et al. | Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs. | 1986 | Dev Pharmacol Ther | pmid:3530674 |
| Hiroshima O et al. | Basal level of prostaglandin D2 in rat brain by a solid-phase enzyme immunoassay. | 1986 | Prostaglandins | pmid:3532208 |
| Strobl-Jäger E et al. | Influence of type IIa, IIb and IV-hyperlipoproteinemia on platelet prostaglandin sensitivity, plasma thromboxane B2 and platelet half-life. | 1986 | Prostaglandins Leukot Med | pmid:3540998 |