PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Wounds, Stab D014951 3 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Urticaria D014581 13 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Uremia D014511 33 associated lipids
Trigeminal Neuralgia D014277 1 associated lipids
Translocation, Genetic D014178 20 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Hatanaka M et al. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. 2010 J. Pharmacol. Sci. pmid:20424389
Hashimoto Y et al. Prostaglandin D2 inhibits IgE-mediated scratching by suppressing histamine release from mast cells. 2005 J. Pharmacol. Sci. pmid:15879676
Takata K et al. Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. 2003 J. Pharmacol. Sci. pmid:12719662
Narumiya S et al. Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and delta 12-prostaglandin J2 in nuclei. 1987 J. Pharmacol. Exp. Ther. pmid:3302206
Nagira Y et al. Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs. 2016 J. Pharmacol. Exp. Ther. pmid:26945085
Almishri W et al. Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. 2005 J. Pharmacol. Exp. Ther. pmid:15590767
van den Brule S et al. The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. 2010 J. Pharmacol. Exp. Ther. pmid:20719937
Hattori Y and Levi R Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. 1986 J. Pharmacol. Exp. Ther. pmid:3012066
Sharif NA et al. Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. 1996 J. Pharmacol. Exp. Ther. pmid:8819509
Sharif NA et al. Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids. 2000 J. Pharmacol. Exp. Ther. pmid:10772998
Regal JF Role of arachidonate metabolites in C5a-induced bronchoconstriction. 1988 J. Pharmacol. Exp. Ther. pmid:2841450
Pettipher R et al. Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. 2012 J. Pharmacol. Exp. Ther. pmid:22106101
Hernandez JM and Janssen LJ Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments. 2011 J. Pharmacol. Exp. Ther. pmid:21768224
Peters SP et al. Mediator release from human lung under conditions of reduced oxygen tension. 1986 J. Pharmacol. Exp. Ther. pmid:2425080
Lacal PM et al. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. 1994 J. Pharmacol. Exp. Ther. pmid:7965770
Lacal PM et al. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. 1994 J. Pharmacol. Exp. Ther. pmid:7965771
Kriseman T et al. Analysis of airway responses to A23187 in the cat. 1986 J. Pharmacol. Exp. Ther. pmid:3095538
Charlesworth EN et al. Effect of H1 receptor blockade on the early and late response to cutaneous allergen challenge. 1992 J. Pharmacol. Exp. Ther. pmid:1382132
Majewska MD and Chuang DM Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells. 1985 J. Pharmacol. Exp. Ther. pmid:2857784
Napimoga MH et al. 15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor. 2008 J. Pharmacol. Exp. Ther. pmid:17928570
Shiraishi Y et al. Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. 2005 J. Pharmacol. Exp. Ther. pmid:15528449
Monneret G et al. Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. 2005 J. Pharmacol. Exp. Ther. pmid:15388786
Ellis JL and Undem BJ Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea. 1992 J. Pharmacol. Exp. Ther. pmid:1323657
Undem BJ and Adams GK An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea. 1988 J. Pharmacol. Exp. Ther. pmid:2839671
Narumiya S and Fukushima M Site and mechanism of growth inhibition by prostaglandins. I. Active transport and intracellular accumulation of cyclopentenone prostaglandins, a reaction leading to growth inhibition. 1986 J. Pharmacol. Exp. Ther. pmid:3772804
Narumiya S et al. Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei. 1986 J. Pharmacol. Exp. Ther. pmid:3772805
Arakida Y et al. In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. 1998 J. Pharmacol. Exp. Ther. pmid:9808690
Tajima T et al. Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). 2008 J. Pharmacol. Exp. Ther. pmid:18492946
Underwood DC et al. Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig. 1994 J. Pharmacol. Exp. Ther. pmid:8301572
Weichman BM et al. SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. 1984 J. Pharmacol. Exp. Ther. pmid:6582266
Zhang XC et al. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. 2007 J. Pharmacol. Exp. Ther. pmid:17483291
Papaliodis D et al. Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model. 2008 J. Pharmacol. Exp. Ther. pmid:18784348
Rangachari PK et al. Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? 1995 J. Pharmacol. Exp. Ther. pmid:7473146
Undem BJ et al. Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. 1988 J. Pharmacol. Exp. Ther. pmid:2459368
Spannhake EW et al. Influence of mediators of anaphylaxis on collateral ventilation and the lung periphery of the dog. 1985 J. Pharmacol. Exp. Ther. pmid:3860642
Sugimoto H et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. 2003 J. Pharmacol. Exp. Ther. pmid:12649388
Casolaro V et al. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. 1993 J. Pharmacol. Exp. Ther. pmid:7505332
Ohno K et al. Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. 1988 J. Pharmacol. Exp. Ther. pmid:3361448
Kim EJ et al. Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. 2003 J. Pharmacol. Exp. Ther. pmid:12966153
Woodward DF et al. Thromboxane A2-mimetics are potent microvascular permeability factors in the conjunctiva. 1990 J. Pharmacol. Exp. Ther. pmid:2213558
Shichijo M et al. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. 2003 J. Pharmacol. Exp. Ther. pmid:12975488
Tachikawa M et al. A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters. 2012 J. Pharmacol. Exp. Ther. pmid:22931759
Hata AN et al. Expression and molecular pharmacology of the mouse CRTH2 receptor. 2003 J. Pharmacol. Exp. Ther. pmid:12721327
Leduc M et al. Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. 2009 J. Pharmacol. Exp. Ther. pmid:19584306
Eguchi N et al. Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats. 1992 J. Pharmacol. Exp. Ther. pmid:1527717
Hewson CA et al. Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. 2012 J. Pharmacol. Exp. Ther. pmid:22160268
Peters SP et al. Effect of prostaglandin D2 in modulating histamine release from human basophils. 1984 J. Pharmacol. Exp. Ther. pmid:6198512
Stier CT et al. Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. 1987 J. Pharmacol. Exp. Ther. pmid:3479549
Yu R et al. Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. 2011 J. Pharmacol. Exp. Ther. pmid:21865441
Shimomura K et al. Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. 2004 J. Pharmacol. Exp. Ther. pmid:15201343
Monneret G et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. 2003 J. Pharmacol. Exp. Ther. pmid:12490611
Cossette C et al. Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils. 2007 J. Pharmacol. Exp. Ther. pmid:17041009
Raman P et al. 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. 2012 J. Pharmacol. Exp. Ther. pmid:22700433
Minami T et al. Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. 1996 J. Pharmacol. Exp. Ther. pmid:8819497
Yokotani K et al. Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats. 1988 J. Pharmacol. Exp. Ther. pmid:3422095
Ko FN et al. Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. 1996 J. Pharm. Pharmacol. pmid:8794990
Bhattacharya SK et al. Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats. 1989 J. Pharm. Pharmacol. pmid:2571705
Sharif NA and Davis TL Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. 2002 J. Pharm. Pharmacol. pmid:11999132
Gambero A and Gomes JC Pharmacological antagonism of Anchietia salutaris extracts on the contraction induced by prostaglandin D2 and U46619 in guinea-pig lung parenchymal strips. 1998 J. Pharm. Pharmacol. pmid:9877316
Guh JH et al. Antiplatelet effect of gingerol isolated from Zingiber officinale. 1995 J. Pharm. Pharmacol. pmid:7791032
Bhattacharya SK and Parmar SS Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine. 1985 J. Pharm. Pharmacol. pmid:2868104
Bhattacharya SK and Rao PJ Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine. 1987 J. Pharm. Pharmacol. pmid:2890744
Mendieta CF et al. Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. 1985 J. Periodontol. pmid:3919173
Siddhivarn C et al. Mechanical loading and delta12prostaglandin J2 induce bone morphogenetic protein-2, peroxisome proliferator-activated receptor gamma-1, and bone nodule formation in an osteoblastic cell line. 2007 J. Periodont. Res. pmid:17760815
Siddhivarn C et al. Prostaglandin D2 pathway and peroxisome proliferator-activated receptor gamma-1 expression are induced by mechanical loading in an osteoblastic cell line. 2006 J. Periodont. Res. pmid:16499711
Ford WD et al. Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. 1990 J. Pediatr. Surg. pmid:2352080
Soifer SJ et al. Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. 1988 J. Pediatr. pmid:3162978
Mirza RE et al. Macrophage PPARγ and impaired wound healing in type 2 diabetes. 2015 J. Pathol. pmid:25875529
Hokari R et al. Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. 2009 J. Pathol. pmid:19768745
Gao T et al. Arachidonic acid metabolism to prostaglandin E2, D2, F2alpha, and I2 in the plerocercoid of Spirometra erinaceieuropaei. 1998 J. Parasitol. pmid:9920298
Zanoni G et al. First enantioselective total synthesis of (8S,12R,15S)-prostaglandin J(2). 2003 J. Org. Chem. pmid:12895084
Zanoni G et al. A --> J prostaglandin swap: a new tactic for cyclopentenone prostaglandin synthesis. 2003 J. Org. Chem. pmid:12919053
Zanoni G et al. First total synthesis of JS isoprostane. 2003 J. Org. Chem. pmid:12868940
Kim NJ et al. Concise and enantioselective total synthesis of 15-deoxy-Δ-(12,14)-prostaglandin J(2). 2010 J. Org. Chem. pmid:20929274
Patel P et al. Enantio- and stereospecific syntheses of 15(R)-Me-PGD2, a potent and selective DP2-receptor agonist. 2008 J. Org. Chem. pmid:18700746
Nakagomi T et al. Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries. 1988 J. Neurosurg. pmid:2895803
Rodriguez y Baena R et al. Effects of nicardipine on the ex vivo release of eicosanoids after experimental subarachnoid hemorrhage. 1989 J. Neurosurg. pmid:2585083
Chattopadhyay N et al. Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis. 2000 J. Neurosci. Res. pmid:10861801
Li Z et al. Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? 2004 J. Neurosci. Res. pmid:15523637
Storer PD et al. Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. 2005 J. Neurosci. Res. pmid:15723383
Smith SA et al. Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability. 2003 J. Neurosci. Res. pmid:12774315
Alvarez-Dolado M et al. Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. 1999 J. Neurosci. Res. pmid:10502285
Kim SE et al. 15-deoxy-Δ¹²,¹⁴ -prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-γ and heme oxygenase-1 in rat hippocampal slices. 2012 J. Neurosci. Res. pmid:22487967
Lysz TW et al. Measurement of prostaglandin biosynthetic capacity in discrete areas of the rabbit hippocampal formation. 1983 J. Neurosci. Res. pmid:6580469
Mohri I et al. Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. 2006 J. Neurosci. pmid:16624958
Heneka MT et al. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. 2000 J. Neurosci. pmid:10995830
Lee B et al. Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero. 2002 J. Neurosci. pmid:12097519
Taniguchi H et al. Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. 2007 J. Neurosci. pmid:17442814
Terao A et al. Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. 1998 J. Neurosci. pmid:9698346
Mouihate A et al. A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. 2004 J. Neurosci. pmid:14960602
Tan W et al. Modulation of nicotinic AChR channels by prostaglandin E2 in chick sympathetic ganglion neurons. 1998 J. Neurophysiol. pmid:9463448
De Nuccio C et al. Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. 2011 J. Neuropathol. Exp. Neurol. pmid:21937914
Bernardo A et al. Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. 2009 J. Neuropathol. Exp. Neurol. pmid:19535992
Rodriguez y Baena R et al. A study on cisternal CSF levels of arachidonic acid metabolites after aneurysmal subarachnoid hemorrhage. 1988 J. Neurol. Sci. pmid:3132538
Zhang F et al. Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells. 2010 J. Neuroimmunol. pmid:19942298
Waits PS et al. Nociceptin/orphanin FQ modulates human T cell function in vitro. 2004 J. Neuroimmunol. pmid:15020071
Diab A et al. Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. 2004 J. Neuroimmunol. pmid:14975592
Garg TK and Chang JY Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. 2006 J. Neuroimmunol. pmid:16225932
Heneka MT et al. Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase. 1999 J. Neuroimmunol. pmid:10695726
Froldi M et al. Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement. 1992 J. Neuroimmunol. pmid:1315794