| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peritonitis | D010538 | 38 associated lipids |
| Urticaria Pigmentosa | D014582 | 4 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Hematoma | D006406 | 5 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim SJ et al. | Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:17121182 |
| Berruyer C et al. | Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. | 2006 | J. Exp. Med. | pmid:17145956 |
| Qu WM et al. | Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17093043 |
| Arai I | [Role of cutaneous prostaglandin D2 production on scratching dermatitis in mice]. | 2006 | Nippon Yakurigaku Zasshi | pmid:17167214 |
| Akabane H et al. | Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. | 2006 | Allergol Int | pmid:17130681 |
| Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
| Mazid MA et al. | Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. | 2006 | FEBS Lett. | pmid:17150216 |
| Barreto EO et al. | High levels of filamentous actin and apoptosis correlate with mast cell refractoriness under alloxan-evoked diabetes. | 2006 | Life Sci. | pmid:16647092 |
| Funovics P et al. | Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647637 |
| Jin MH et al. | Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. | 2006 | Biol. Pharm. Bull. | pmid:16651713 |
| Mohri I et al. | Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. | 2006 | J. Neurosci. | pmid:16624958 |
| Hauser B et al. | Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. | 2006 | Intensive Care Med | pmid:16534570 |
| Lee SJ et al. | Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation. | 2006 | Mol. Pharmacol. | pmid:16611854 |
| Rockwell CE et al. | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | 2006 | Mol. Pharmacol. | pmid:16611855 |
| Arnold R and König W | Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | 2006 | Virology | pmid:16616290 |
| Cheng K et al. | Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16617107 |
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| Ding J et al. | Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. | 2006 | Mol. Carcinog. | pmid:16385588 |
| Landar A et al. | Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16387790 |
| Lee S et al. | Rosiglitazone ameliorates cisplatin-induced renal injury in mice. | 2006 | Nephrol. Dial. Transplant. | pmid:16728429 |
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| Suzuki T et al. | Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. | 2006 | Endocr. Relat. Cancer | pmid:16601291 |
| Helliwell RJ et al. | Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. | 2006 | J. Clin. Endocrinol. Metab. | pmid:16291703 |
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| Cesario RM et al. | Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. | 2006 | Cancer Lett. | pmid:16271436 |
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| Garg TK and Chang JY | Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16225932 |
| Shiraki T et al. | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. | 2006 | Biochem. J. | pmid:16236024 |
| Cho WH et al. | 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. | 2006 | Neurochem. Res. | pmid:17006759 |
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| Phulwani NK et al. | 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. | 2006 | J. Neurochem. | pmid:17074064 |
| Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |
| Aquila S et al. | Peroxisome proliferator-activated receptor (PPAR)gamma is expressed by human spermatozoa: its potential role on the sperm physiology. | 2006 | J. Cell. Physiol. | pmid:16972250 |
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| Zhang YJ et al. | Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). | 2006 | Am. J. Nephrol. | pmid:16864989 |
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| King VL et al. | Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16514081 |
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| Ishida A et al. | Characterization of cAMP-dependent proteolysis of GATA-6. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15913546 |
| Hennersdorf F et al. | Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. | 2005 | Cell Res. | pmid:15916720 |
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| Andrews WJ et al. | Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862961 |
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| Capobianco E et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. | 2005 | Reprod. Fertil. Dev. | pmid:15899154 |