Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moulin D et al. | Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. | 2005 | Arthritis Rheum. | pmid:15751073 |
Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
Maicas N et al. | Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. | 2012 | Arthritis Rheum. | pmid:21898357 |
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Murakami Y et al. | Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. | 2003 | Arthritis Rheum. | pmid:14558100 |
Fahmi H et al. | Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. | 2001 | Arthritis Rheum. | pmid:11263774 |
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Inoue K et al. | Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. | 2004 | Arzneimittelforschung | pmid:15612612 |
Misawa M and Kanai Y | Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. | 1991 | Arzneimittelforschung | pmid:1725697 |
Arisawa M et al. | Suppressive effect of prostaglandin D2 on prolactin secretion from rat anterior pituitary. | 1985 | Asia Oceania J Obstet Gynaecol | pmid:3860198 |
Arisawa M et al. | Direct suppressive effect of prostaglandin D2 on growth hormone secretion from rat anterior pituitary. | 1984 | Asia Oceania J Obstet Gynaecol | pmid:6598030 |
Muhammad SN et al. | 15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. | 2016 | Asian Pac. J. Cancer Prev. | pmid:27509924 |
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Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
Abbate R et al. | Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:3857047 |
Nilsson J and Olsson AG | Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. | 1984 | Atherosclerosis | pmid:6093830 |
Chang MC et al. | Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. | 2011 | Atherosclerosis | pmid:21993412 |
Ledwidge MT et al. | In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin? | 2012 | Atherosclerosis | pmid:22326030 |
Inoue T et al. | Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. | 2008 | Atherosclerosis | pmid:18436228 |
Meyers CD et al. | Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. | 2007 | Atherosclerosis | pmid:16945375 |
Tachi M et al. | Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. | 2014 | Auton Neurosci | pmid:24447364 |
Jin YR et al. | An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. | 2005 | Basic Clin. Pharmacol. Toxicol. | pmid:16128910 |
Li P et al. | [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679661 |
Li CF et al. | [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. | 2007 | Beijing Da Xue Xue Bao | pmid:17304332 |
Varma D et al. | Comparison of UHPLC and HPLC methods for the assay of prostanoids: "are the methods equivalent in terms of accuracy and precision?". | 2011 | Bioanalysis | pmid:21510759 |
Matsuo T et al. | 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741709 |
Józkowicz A et al. | Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14715242 |
Odani N et al. | Induction of protein disulfide isomerase mRNA by delta 12-prostaglandin J2. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645293 |
Yamamoto K et al. | Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3056405 |
Doyle MC et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23333326 |
Chen NG and Han X | Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401521 |
Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
Bamba H et al. | Prostaglandins up-regulate vascular endothelial growth factor production through distinct pathways in differentiated U937 cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873632 |
Asami-Miyagishi R et al. | Expression and function of PPARgamma in rat placental development. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14766236 |
Wong GW et al. | Ancient origin of mast cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25094046 |
Satoh H et al. | Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9920814 |
Ohtani-Fujita N et al. | p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792828 |
Ghosh AK et al. | Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18627765 |
Shen ZN et al. | Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15694358 |
Morii H and Watanabe Y | Solubilization of prostaglandin D2 binding protein from porcine temporal cortex. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1989614 |
Saito S et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14575689 |
Baregamian N et al. | PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19114032 |
Reddy ST et al. | Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10548515 |
Pelton PD et al. | PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425206 |
Feinstein MB et al. | The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin). | 1983 | Biochem. Biophys. Res. Commun. | pmid:6307295 |
Hinz B et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604364 |
Miwa Y et al. | Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15158456 |
Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |