Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
Lu Y et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. | 2013 | Nephron Exp. Nephrol. | pmid:23887394 |
Takayama F et al. | Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia. | 2013 | J. Neuroimmunol. | pmid:23850486 |
Nakagawa T et al. | A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old. | 2013 | Clin. Chim. Acta | pmid:23603101 |
Dave M and Amin AR | Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: reversal by celecoxib. | 2013 | Immunol. Lett. | pmid:23603366 |
Marcone S and Fitzgerald DJ | Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. | 2013 | Proteomics | pmid:23606334 |
Tasaki M et al. | Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of "chemoattractant receptor homologous molecule expressed on Th2 cells" (CRTH2). | 2013 | Eur J Pharm Sci | pmid:23624353 |
Taketomi Y et al. | Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. | 2013 | Nat. Immunol. | pmid:23624557 |
Fernandez-Bustamante A et al. | Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. | 2013 | Inflammation | pmid:23616184 |
Schmidt JA et al. | Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. | 2013 | Br. J. Pharmacol. | pmid:23146091 |
Aukema HM et al. | Dietary fish oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. | 2013 | Br. J. Nutr. | pmid:23151363 |
Frieri M et al. | Mast cell activation syndrome: a review. | 2013 | Curr Allergy Asthma Rep | pmid:23179866 |
Shashni B et al. | Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology. | 2013 | J Drug Target | pmid:23130662 |
Abraki SB et al. | Simultaneous inhibition of COX-2 and activation of PPAR-γ resulted in the same level and pattern of neuroprotection as they were targeted separately. | 2013 | J. Mol. Neurosci. | pmid:23132402 |
Shin J et al. | Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1. | 2013 | Eur. J. Immunol. | pmid:23065777 |
Mruwat R et al. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. | 2013 | PLoS ONE | pmid:24204651 |
Liu L et al. | Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. | 2013 | PLoS ONE | pmid:24023668 |
Harizi H | The immunobiology of prostanoid receptor signaling in connecting innate and adaptive immunity. | 2013 | Biomed Res Int | pmid:24024207 |
Kim KH et al. | Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2. | 2013 | Free Radic. Biol. Med. | pmid:24029383 |
Endo S et al. | Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin Dâ‚‚, and other endogenous and xenobiotic carbonyl compounds. | 2013 | Biochem. Pharmacol. | pmid:23994167 |
Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
Sayers BC et al. | Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23642096 |
Tan BS et al. | 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). | 2013 | Cancer Lett. | pmid:23612072 |
Yaacob NS et al. | Influence of 17β-estradiol on 15-deoxy-δ12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24377602 |
Chi Y et al. | [Effect of 15-deoxy-Δ(12), 14-prostaglandin J2 on the cytokines in the culture supernatant of bone marrow mesenchymal stem cells]. | 2013 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24370048 |
Bolton C et al. | N-Methyl-D-aspartate (NMDA) receptor involvement in central nervous system prostaglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE). | 2013 | Fundam Clin Pharmacol | pmid:22742874 |
Kattamuri PV et al. | Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. | 2013 | Life Sci. | pmid:22820546 |
Idborg H et al. | Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23916744 |
Gonzalez-Rodriguez PJ et al. | Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway. | 2014 | PLoS ONE | pmid:25474649 |
Kurzynska A et al. | Peroxisome proliferator activated receptor ligands affect progesterone and 17β-estradiol secretion by porcine corpus luteum during early pregnancy. | 2014 | J. Physiol. Pharmacol. | pmid:25371531 |
Tsubosaka Y et al. | A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation. | 2014 | J. Immunol. | pmid:25362177 |
Korbecki J et al. | Cyclooxygenase pathways. | 2014 | Acta Biochim. Pol. | pmid:25343148 |
Nieves A and Garza LA | Does prostaglandin D2 hold the cure to male pattern baldness? | 2014 | Exp. Dermatol. | pmid:24521203 |
Jeong KT et al. | Anti-allergic effect of a Korean traditional medicine, Biyeom-Tang on mast cells and allergic rhinitis. | 2014 | BMC Complement Altern Med | pmid:24521096 |
Reddy PH | Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction. | 2014 | J. Alzheimers Dis. | pmid:24413616 |
Zhang S et al. | Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus. | 2014 | Dis. Esophagus | pmid:24165271 |
Kaplan J et al. | Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis. | 2014 | Innate Immun | pmid:24029145 |
Filep JG | Glucocorticoid protection against myocardial ischemia-reperfusion injury: central role for the PGD2-Nrf2 pathway. | 2014 | Hypertension | pmid:24101660 |
Katsumata Y et al. | Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. | 2014 | Hypertension | pmid:24101662 |
Mello CF and Oliveira MS | Commentary on Kaushik et al.: Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Novel evidence supporting a role for prostanoid receptors in seizure control. | 2014 | Exp. Neurol. | pmid:24814715 |
Casali CI et al. | Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells. | 2014 | Biochem. Pharmacol. | pmid:24915420 |
Sturm EM et al. | Opposing roles of prostaglandin D2 receptors in ulcerative colitis. | 2014 | J. Immunol. | pmid:24929001 |
Oyama S et al. | A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. | 2014 | Arch. Biochem. Biophys. | pmid:24239863 |
Liu H et al. | Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus. | 2014 | Immunology | pmid:24329550 |
Chen S et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells. | 2014 | Chem. Biol. Interact. | pmid:24582817 |
Brugha RE et al. | Carbon in airway macrophages from children with asthma. | 2014 | Thorax | pmid:24567296 |
Takeshima Y | [Development of novel therapeutic approaches for Duchenne muscular dystrophy]. | 2014 | No To Hattatsu | pmid:24738186 |
Kang ES et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells. | 2014 | Free Radic. Res. | pmid:24180671 |
Pierron A et al. | PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2. | 2014 | J. Dermatol. Sci. | pmid:24289988 |
Tachikawa M et al. | Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers. | 2014 | Adv. Pharmacol. | pmid:25307222 |