PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Liver Cirrhosis, Experimental D008106 36 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia, Megakaryoblastic, Acute D007947 7 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia P388 D007941 43 associated lipids
Leukemia D007938 74 associated lipids
Leiomyoma D007889 8 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Inflammation D007249 119 associated lipids
Hypothermia D007035 19 associated lipids
Hypotension D007022 41 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity D006967 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Kim HJ et al. ROSics: chemistry and proteomics of cysteine modifications in redox biology. 2015 Mar-Apr Mass Spectrom Rev pmid:24916017
Le Loupp AG et al. [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. 2015 Jun-Jul Med Sci (Paris) pmid:26152165
Meng Y et al. Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. 2015 Cell. Physiol. Biochem. pmid:25591955
Penas F et al. Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. 2015 Biochim. Biophys. Acta pmid:25557389
Oishi Y et al. The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. 2015 Brain Behav. Immun. pmid:25532785
Fukuoka T et al. Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ. 2015 Int. J. Cancer pmid:25516376
Säfholm J et al. Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. 2015 J. Allergy Clin. Immunol. pmid:25962903
Wallert M et al. α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. 2015 Mol Nutr Food Res pmid:25943249
Ott D et al. Prostaglandin D2 modulates calcium signals induced by prostaglandin E2 in neurons of rat dorsal root ganglia. 2015 Neurosci. Lett. pmid:25912777
Willenberg I et al. Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). 2015 J Chromatogr A pmid:25777050