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Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. |
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Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. |
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Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. |
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PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes. |
2003 |
Hypertension |
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Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. |
2003 |
Gastroenterology |
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Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis. |
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First total synthesis of JS isoprostane. |
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Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation. |
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Mol. Cell. Biochem. |
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Cytokines, prostaglandins and parturition--a review. |
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Placenta |
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Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. |
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J. Immunol. |
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Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. |
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Liver Int. |
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Molecular characterization of human and rat organic anion transporter OATP-D. |
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Am. J. Physiol. Renal Physiol. |
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COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. |
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Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. |
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Blood |
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Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. |
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Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process. |
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Carcinogenesis |
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Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. |
2003 |
Shock |
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Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. |
2003 |
Oncogene |
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Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. |
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Eur. J. Neurosci. |
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Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. |
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Mol. Pharmacol. |
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The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. |
2003 |
Pancreas |
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Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. |
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J. Immunol. |
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Sleep regulation in adenosine A2A receptor-deficient mice. |
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Neurology |
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Exhaled leukotrienes and prostaglandins in COPD. |
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Thorax |
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The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. |
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Melanoma Res. |
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15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. |
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Am. J. Physiol. Heart Circ. Physiol. |
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Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. |
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Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. |
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Acta Biochim. Pol. |
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15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. |
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Prostaglandins Other Lipid Mediat. |
pmid:14518569
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Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. |
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Arch. Toxicol. |
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The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells. |
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Int. J. Mol. Med. |
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Modulation of guinea pig intrinsic cardiac neurons by prostaglandins. |
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Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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The PPARgamma ligand, 15-Deoxy-Delta12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. |
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Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis. |
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Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. |
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Mol. Pharmacol. |
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Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. |
2003 |
Br. J. Pharmacol. |
pmid:12970094
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Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. |
2003 |
Surgery |
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Peroxisome proliferator-activated receptor-gamma activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis. |
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J. Huazhong Univ. Sci. Technol. Med. Sci. |
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15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. |
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World J. Gastroenterol. |
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Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. |
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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. |
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J. Pharmacol. Exp. Ther. |
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Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. |
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FASEB J. |
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Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. |
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J. Allergy Clin. Immunol. |
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15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. |
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Lab. Invest. |
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Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. |
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DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. |
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Exp. Hematol. |
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Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. |
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Biochem. Biophys. Res. Commun. |
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Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. |
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FASEB J. |
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Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1. |
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Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. |
2003 |
BMC Ophthalmol |
pmid:12659653
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[Trend in chemical mediator research in asthma and its application for asthma treatment]. |
2003 |
Nihon Kokyuki Gakkai Zasshi |
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Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2. |
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[Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. |
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Korean J Gastroenterol |
pmid:14532729
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Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. |
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Biol. Reprod. |
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Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
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A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. |
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J. Allergy Clin. Immunol. |
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15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. |
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J. Neurochem. |
pmid:14535956
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15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. |
2003 |
J. Cell. Physiol. |
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2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. |
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FEBS Lett. |
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Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. |
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Am. J. Respir. Cell Mol. Biol. |
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Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. |
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Prostaglandins Leukot. Essent. Fatty Acids |
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The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. |
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J. Immunol. |
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Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. |
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Activation of peroxisome proliferator-activated receptor alpha in human endothelial cells increases plasminogen activator inhibitor type-1 expression. |
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Chin. Med. J. |
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Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. |
2003 |
Eur. J. Immunol. |
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A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2. |
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Infect. Immun. |
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Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. |
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Thioredoxin as a molecular target of cyclopentenone prostaglandins. |
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Regulation of heme oxygenase expression by cyclopentenone prostaglandins. |
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Exp. Biol. Med. (Maywood) |
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Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. |
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J. Invest. Dermatol. |
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Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). |
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Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. |
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J. Leukoc. Biol. |
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The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. |
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Cancer Res. |
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Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria. |
2003 |
Pharmacology |
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Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. |
2003 |
Biochim. Biophys. Acta |
pmid:12573447
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Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. |
2003 |
Brain Res. Mol. Brain Res. |
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Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. |
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J. Immunol. |
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PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. |
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J. Am. Soc. Nephrol. |
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The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. |
2003 |
Br. J. Pharmacol. |
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Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. |
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Mol. Cell. Biol. |
pmid:12556480
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Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. |
2003 |
Biochem. Biophys. Res. Commun. |
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15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. |
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J. Biol. Chem. |
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15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. |
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Biochem. Biophys. Res. Commun. |
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Kalla R et al. |
Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. |
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Glia |
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Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-gamma. |
2003 |
J. Am. Soc. Nephrol. |
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Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. |
2003 |
Int. J. Cancer |
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Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. |
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Am. J. Physiol. Endocrinol. Metab. |
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Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. |
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J. Immunol. |
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Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. |
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Biochem. J. |
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Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. |
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Arterioscler. Thromb. Vasc. Biol. |
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Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. |
2003 |
J Ocul Pharmacol Ther |
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Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. |
2003 |
Biochem. Biophys. Res. Commun. |
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Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. |
2003 |
BioTechniques |
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